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• W4311896052 abstract "Fetal alcohol spectrum disorder (FASD) is a lifelong condition. Early interventions targeting core neurocognitive deficits have the potential to confer long-term neurodevelopmental benefits. Time-targeted choline supplementation is one such intervention that has been shown to provide neurodevelopmental benefits that emerge with age during childhood. We present a long-term follow-up study evaluating the neurodevelopmental effects of early choline supplementation in children with FASD approximately 7 years on average after an initial efficacy trial.The initial study was a randomized, double-blind, placebo-controlled trial of choline vs. placebo in 2.5 to 5 year olds with FASD. Participants in this long-term follow-up study include 18 children (9 placebo; 9 choline) seen 7 years on average following initial trial completion. The mean age at follow-up was 11.0 years old. Diagnoses were 28% fetal alcohol syndrome (FAS), 28% partial FAS, and 44% alcohol-related neurodevelopmental disorder. The follow-up included measures of executive functioning and an MRI scan.Children who received choline had better performance on several tasks of lower-order executive function (e.g., processing speed) and showed higher white matter microstructure organization (i.e., greater axon coherence) in the splenium of the corpus callosum compared to the placebo group.These preliminary findings, although exploratory at this stage, highlight potential long-term benefits of choline as a neurodevelopmental intervention for FASD and suggest that choline may affect white matter development, representing a potential target of choline in this population.Prior to enrollment, this trial was registered with clinicaltrials.gov ( NCT01149538 ) on June 23, 2010." @default.
• W4311896052 created "2023-01-02" @default.
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• W4311896052 creator A5081661210 @default.
• W4311896052 date "2022-12-01" @default.
• W4311896052 modified "2023-10-14" @default.
• W4311896052 title "Long-term follow-up of a randomized controlled trial of choline for neurodevelopment in fetal alcohol spectrum disorder: corpus callosum white matter microstructure and neurocognitive outcomes" @default.
• W4311896052 cites W1516210418 @default.
• W4311896052 cites W1532048738 @default.
• W4311896052 cites W1951474008 @default.
• W4311896052 cites W1959428644 @default.
• W4311896052 cites W1967169915 @default.
• W4311896052 cites W1967987181 @default.
• W4311896052 cites W1976053890 @default.
• W4311896052 cites W1981680881 @default.
• W4311896052 cites W1983208069 @default.
• W4311896052 cites W1984467668 @default.
• W4311896052 cites W1984486655 @default.
• W4311896052 cites W1989364786 @default.
• W4311896052 cites W1991742020 @default.
• W4311896052 cites W1993478293 @default.
• W4311896052 cites W1996565528 @default.
• W4311896052 cites W2001612051 @default.
• W4311896052 cites W2005260485 @default.
• W4311896052 cites W2008151965 @default.
• W4311896052 cites W2017124601 @default.
• W4311896052 cites W2017358698 @default.
• W4311896052 cites W2021275639 @default.
• W4311896052 cites W2032254014 @default.
• W4311896052 cites W2033288143 @default.
• W4311896052 cites W2033289257 @default.
• W4311896052 cites W2036091597 @default.
• W4311896052 cites W2042581025 @default.
• W4311896052 cites W2053184611 @default.
• W4311896052 cites W2058921466 @default.
• W4311896052 cites W2065214963 @default.
• W4311896052 cites W2068225058 @default.
• W4311896052 cites W2068393346 @default.
• W4311896052 cites W2070503956 @default.
• W4311896052 cites W2070825470 @default.
• W4311896052 cites W2071739259 @default.
• W4311896052 cites W2077559791 @default.
• W4311896052 cites W2081995492 @default.
• W4311896052 cites W2099263400 @default.
• W4311896052 cites W2104387367 @default.
• W4311896052 cites W2105688210 @default.
• W4311896052 cites W2108656317 @default.
• W4311896052 cites W2110208125 @default.
• W4311896052 cites W2110579639 @default.
• W4311896052 cites W2112778881 @default.
• W4311896052 cites W2113319997 @default.
• W4311896052 cites W2116467526 @default.
• W4311896052 cites W2117079565 @default.
• W4311896052 cites W2121924839 @default.
• W4311896052 cites W2131048195 @default.
• W4311896052 cites W2132895437 @default.
• W4311896052 cites W2148386452 @default.
• W4311896052 cites W2149546901 @default.
• W4311896052 cites W2154860382 @default.
• W4311896052 cites W2158694460 @default.
• W4311896052 cites W2162654847 @default.
• W4311896052 cites W2162768785 @default.
• W4311896052 cites W2165698928 @default.
• W4311896052 cites W2167408532 @default.
• W4311896052 cites W2170820568 @default.
• W4311896052 cites W2217566338 @default.
• W4311896052 cites W2325707468 @default.
• W4311896052 cites W2400490172 @default.
• W4311896052 cites W2492998196 @default.
• W4311896052 cites W2501434238 @default.
• W4311896052 cites W2547655254 @default.
• W4311896052 cites W2553870686 @default.
• W4311896052 cites W2604083418 @default.
• W4311896052 cites W2745760221 @default.
• W4311896052 cites W2746656553 @default.
• W4311896052 cites W2759785505 @default.
• W4311896052 cites W2771343361 @default.
• W4311896052 cites W2792288381 @default.
• W4311896052 cites W2800494954 @default.
• W4311896052 cites W2800508230 @default.
• W4311896052 cites W2809485975 @default.
• W4311896052 cites W2810190442 @default.
• W4311896052 cites W2884836906 @default.
• W4311896052 cites W2886795134 @default.
• W4311896052 cites W2893411620 @default.
• W4311896052 cites W2895427157 @default.
• W4311896052 cites W2939851233 @default.
• W4311896052 cites W2943991403 @default.
• W4311896052 cites W2944367981 @default.

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