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• W4311897803 abstract "Objectives: Psychological trauma often co-occurs with pain. This relationship has been explored using laboratory pain measures; however, findings have been mixed. Previous studies have limited operationalization of trauma (eg, posttraumatic stress disorder) or pain (eg, pain thresholds), which may contribute to conflicting results. Further, prior reviews likely underrepresent trauma experiences among people who are not receiving clinical care, limiting generalizability. Materials and Methods: We systematically reviewed the existing literature on the relationship between psychological trauma (eg, car accidents, sexual assault, childhood abuse, neglect) and laboratory pain (ie, quantitative sensory testing measures of pain threshold, intensity, summation, modulation), using inclusive criteria. The direction of the relationship between psychological trauma and pain sensitivity was evaluated, and moderation by purported pain mechanism (ie, pain detection, suprathreshold pain, central sensitization, inhibition) was explored. Results: Analyses were conducted using 48 studies that provided 147 effect sizes. A multivariate random-effects model with robust variance estimation resulted in a small but statistically significant overall effect size of g =0.24 ( P =0.0002), reflecting a positive association between psychological trauma and enhanced laboratory pain sensitivity. Upon examination of mechanistic moderators, this relationship appears driven by effects on pain detection ( g =0.28, P =0.002) and central sensitization ( g =0.22, P =0.04). While effect sizes were similar across all moderators, effects on suprathreshold pain and inhibition were not statistically significant. Discussion: Findings demonstrate an overall pattern of trauma-related pain enhancement and point to central sensitization as a key underlying mechanism." @default.
• W4311897803 created "2023-01-02" @default.
• W4311897803 creator A5023800571 @default.
• W4311897803 creator A5032700984 @default.
• W4311897803 creator A5040668101 @default.
• W4311897803 creator A5073319149 @default.
• W4311897803 creator A5087828867 @default.
• W4311897803 date "2022-11-14" @default.
• W4311897803 modified "2023-09-26" @default.
• W4311897803 title "Traumatic Life Experience and Pain Sensitization" @default.
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