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• W4311899423 abstract "Replication of RNA viruses is catalysed by virus-specific polymerases, which can be targets of therapeutic strategies. In this study, we used a selection strategy to identify endogenous RNAs from a transcriptome library derived from lung cells that interact with the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. Some of the selected RNAs weakened the activity of RdRp by forming G-quadruplexes. These results suggest that certain endogenous RNAs, which potentially form G-quadruplexes, can reduce the replication of viral RNAs." @default.
• W4311899423 created "2023-01-02" @default.
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• W4311899423 date "2023-01-01" @default.
• W4311899423 modified "2023-10-17" @default.
• W4311899423 title "Endogenous G-quadruplex-forming RNAs inhibit the activity of SARS-CoV-2 RNA polymerase" @default.
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• W4311899423 doi "https://doi.org/10.1039/d2cc05858h" @default.
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