Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311904080> ?p ?o ?g. }
- W4311904080 endingPage "109358" @default.
- W4311904080 startingPage "109358" @default.
- W4311904080 abstract "Fifty years ago, the late Geoffrey Burnstock described the concept of purinergic nerves and transmission bringing into existence the broader concepts of purinergic signaling including P2X receptors. These receptors are trimeric ligand-gated cation channels activated by extracellular adenosine 5'-triphosphate (ATP). P2X receptors have important roles in health and disease and continue to gain interest as potential therapeutic targets in inflammatory, neurological, cardiovascular and many other disorders including cancer. Current understanding of P2X receptors has largely arisen from the study of these receptors in humans and rodents, but additional insights have been obtained from the study of P2X receptors in the domestic dog, Canis familiaris. This review article will briefly introduce purinergic signaling and P2X receptors, before detailing the pharmacological profiles of the two recombinant canine P2X receptors studied to date, P2X7 and P2X4. The article will then describe the current state of knowledge concerning the distribution and function of the P2X receptor family in dogs. The article will also discuss the characterization of single nucleotide polymorphisms in the canine P2RX7 gene, and contrast this variation to the canine P2RX4 gene, which is largely conserved between dogs. Finally, this article will outline published examples of the use of dogs to study the pharmacokinetics of P2X7 and P2X3 antagonists, and how they have contributed to the preclinical testing of antagonists to human P2X7, CE-224,535, and human P2X3, Gefapixant (AF-219, MK-7264) and Eliapixant (BAY, 1817080), with Gefapixant gaining recent approval for use in the treatment of refractory chronic cough in humans. This article is part of the Special Issue on 'Purinergic Signaling: 50 years'." @default.
- W4311904080 created "2023-01-02" @default.
- W4311904080 creator A5021311826 @default.
- W4311904080 creator A5041363133 @default.
- W4311904080 creator A5052350687 @default.
- W4311904080 date "2023-02-01" @default.
- W4311904080 modified "2023-10-18" @default.
- W4311904080 title "P2X receptors: Insights from the study of the domestic dog" @default.
- W4311904080 cites W1485797978 @default.
- W4311904080 cites W1490568823 @default.
- W4311904080 cites W1524500351 @default.
- W4311904080 cites W1595178772 @default.
- W4311904080 cites W1608870321 @default.
- W4311904080 cites W1644999085 @default.
- W4311904080 cites W1656859354 @default.
- W4311904080 cites W1674357349 @default.
- W4311904080 cites W1791708082 @default.
- W4311904080 cites W1831482945 @default.
- W4311904080 cites W1832128547 @default.
- W4311904080 cites W1897243328 @default.
- W4311904080 cites W1964678173 @default.
- W4311904080 cites W1966964201 @default.
- W4311904080 cites W1969075854 @default.
- W4311904080 cites W1970469389 @default.
- W4311904080 cites W1972681439 @default.
- W4311904080 cites W1975172757 @default.
- W4311904080 cites W1989918388 @default.
- W4311904080 cites W1992168784 @default.
- W4311904080 cites W1998594826 @default.
- W4311904080 cites W1999260389 @default.
- W4311904080 cites W2004111769 @default.
- W4311904080 cites W2007435066 @default.
- W4311904080 cites W2012072483 @default.
- W4311904080 cites W2013223130 @default.
- W4311904080 cites W2014665250 @default.
- W4311904080 cites W2015495495 @default.
- W4311904080 cites W2025972260 @default.
- W4311904080 cites W2026780812 @default.
- W4311904080 cites W2026928679 @default.
- W4311904080 cites W2028005538 @default.
- W4311904080 cites W2028148892 @default.
- W4311904080 cites W2034589080 @default.
- W4311904080 cites W2036935307 @default.
- W4311904080 cites W2040278093 @default.
- W4311904080 cites W2046824632 @default.
- W4311904080 cites W2049146381 @default.
- W4311904080 cites W2061960048 @default.
- W4311904080 cites W2062112365 @default.
- W4311904080 cites W2069271543 @default.
- W4311904080 cites W2070639102 @default.
- W4311904080 cites W2074050752 @default.
- W4311904080 cites W2075084880 @default.
- W4311904080 cites W2077418346 @default.
- W4311904080 cites W2078323484 @default.
- W4311904080 cites W2079569350 @default.
- W4311904080 cites W2085167407 @default.
- W4311904080 cites W2088918268 @default.
- W4311904080 cites W2092710350 @default.
- W4311904080 cites W2094428264 @default.
- W4311904080 cites W2094458603 @default.
- W4311904080 cites W2095073811 @default.
- W4311904080 cites W2095795382 @default.
- W4311904080 cites W2099163813 @default.
- W4311904080 cites W2105324371 @default.
- W4311904080 cites W2105685878 @default.
- W4311904080 cites W2108577901 @default.
- W4311904080 cites W2113808039 @default.
- W4311904080 cites W2114479245 @default.
- W4311904080 cites W2114611642 @default.
- W4311904080 cites W2124586349 @default.
- W4311904080 cites W2127376430 @default.
- W4311904080 cites W2128310039 @default.
- W4311904080 cites W2130535589 @default.
- W4311904080 cites W2131476134 @default.
- W4311904080 cites W2136732581 @default.
- W4311904080 cites W2146799321 @default.
- W4311904080 cites W2147386725 @default.
- W4311904080 cites W2157382207 @default.
- W4311904080 cites W2160914099 @default.
- W4311904080 cites W2171056382 @default.
- W4311904080 cites W2324277672 @default.
- W4311904080 cites W2325972032 @default.
- W4311904080 cites W2326948553 @default.
- W4311904080 cites W2388784306 @default.
- W4311904080 cites W2404542241 @default.
- W4311904080 cites W2415321706 @default.
- W4311904080 cites W2467892422 @default.
- W4311904080 cites W2516502922 @default.
- W4311904080 cites W2518294982 @default.
- W4311904080 cites W2543985504 @default.
- W4311904080 cites W2612684343 @default.
- W4311904080 cites W2626844040 @default.
- W4311904080 cites W2738757537 @default.
- W4311904080 cites W2739423755 @default.
- W4311904080 cites W2755544565 @default.
- W4311904080 cites W2759752974 @default.
- W4311904080 cites W2766828530 @default.
- W4311904080 cites W2771471373 @default.