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• W4311907249 abstract "Background This study aimed to determine the predictors of hospital-onset Clostridioides difficile infection (CDI) in pediatric patients with antibiotic-associated diarrhea (AAD) and to develop a predictive scoring system to identify at-risk patients. Methods This retrospective case-control study included patients aged ≥2-18 years with AAD who underwent C. difficile polymerase chain reaction testing >3 days after hospital admission. Patients with hospital-onset CDI were selected as cases and matched with the control patients without CDI. Univariate and multivariate logistic regressions were used to determine predictors of CDI and to construct a prediction score for the outcomes of interest. Results Sixty-five patients with hospital-onset CDI and 130 controls were enrolled. Independent predictors for CDI identified and combined into the prediction score included abdominal pain (adjusted odds ratio [95% confidence interval]: 7.940 [3.254-19.374]), hospitalization for ≥14 days before the onset of diarrhea (3.441 [1.034-11.454]), antibiotic use for ≥10 days before the onset of diarrhea (6.775 [1.882-24.388]), receipt of meropenem (4.001 [1.098-14.577]) and clindamycin (14.842 [4.496-49.000]). The area under the receiver operating characteristic curve for this score was 0.883. Conclusions The presented scoring system can be easily applied by clinicians at the bedside to decide which patients with AAD are likely to have CDI." @default.
• W4311907249 created "2023-01-02" @default.
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• W4311907249 date "2023-08-01" @default.
• W4311907249 modified "2023-10-17" @default.
• W4311907249 title "Predictors of hospital-onset Clostridioides difficile infection in children with antibiotic-associated diarrhea" @default.
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• W4311907249 doi "https://doi.org/10.1016/j.ajic.2022.12.004" @default.
• W4311907249 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36535316" @default.
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