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- W4311908907 abstract "Mature IL-33 (MIL33) acting through its receptor, ST2, is known to regulate fibrosis. The precursor, full-length IL-33 (FLIL33), may function differently from MIL33 and independently of ST2. Here we report that genetic deletion of either IL-33 or ST2 attenuates pulmonary fibrosis in the bleomycin model, as does Cre-induced IL-33 deficiency in response to either acute or chronic bleomycin challenge. However, adenovirus-mediated gene delivery of FLIL33, but not MIL33, to the lungs of either wild-type or ST2-deficient mice potentiates the profibrotic effect of bleomycin without inducing a Th2 phenotype. In cultured mouse lung cells, FLIL33 overexpression induces moderate and distinct transcriptomic changes compared with a robust response induced by MIL33, whereas ST2 deletion abrogates the effects of both IL-33 forms. Thus, FLIL33 may contribute to fibrosis in an ST2-independent, Th2-independent, non-transcriptomic fashion, suggesting that pharmacological targeting of both FLIL33 and MIL33 may prove efficacious in patients with pulmonary fibrosis." @default.
- W4311908907 created "2023-01-02" @default.
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- W4311908907 date "2023-01-01" @default.
- W4311908907 modified "2023-10-14" @default.
- W4311908907 title "Full-length IL-33 augments pulmonary fibrosis in an ST2- and Th2-independent, non-transcriptomic fashion" @default.
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- W4311908907 cites W1961573346 @default.
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- W4311908907 cites W1985354520 @default.
- W4311908907 cites W1997883939 @default.
- W4311908907 cites W2001785829 @default.
- W4311908907 cites W2016787193 @default.
- W4311908907 cites W2019546252 @default.
- W4311908907 cites W2027314854 @default.
- W4311908907 cites W2028832882 @default.
- W4311908907 cites W2055183929 @default.
- W4311908907 cites W2069066505 @default.
- W4311908907 cites W2069526125 @default.
- W4311908907 cites W2073666097 @default.
- W4311908907 cites W2078489088 @default.
- W4311908907 cites W2079576820 @default.
- W4311908907 cites W2089208233 @default.
- W4311908907 cites W2091467887 @default.
- W4311908907 cites W2093396768 @default.
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- W4311908907 cites W2179438025 @default.
- W4311908907 cites W2197124664 @default.
- W4311908907 cites W2270215994 @default.
- W4311908907 cites W2298741050 @default.
- W4311908907 cites W2345448809 @default.
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- W4311908907 cites W2726929281 @default.
- W4311908907 cites W2767184621 @default.
- W4311908907 cites W2767919706 @default.
- W4311908907 cites W2779261498 @default.
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- W4311908907 cites W2800105743 @default.
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- W4311908907 doi "https://doi.org/10.1016/j.cellimm.2022.104657" @default.
- W4311908907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36603504" @default.
- W4311908907 hasPublicationYear "2023" @default.
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