Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311924788> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4311924788 abstract "Abstract In de novo deisgn of protein backbones with deep generative methods, the designability or physical plausibility of the generated backbones needs to be emphasized. Here we report SCUBA-D, a method using denoising diffusion with priors of non-zero means to transform a low quality initial backbone into a high quality backbone. SCUBA-D has been developed by gradually adding new components to a basic denoising diffusion module to improve the physical plausibility of the denoised backbone. It comprises a module that uese one-step denoising to generate prior backbones, followed by a high resolution denoising diffusion module, in which structure diffusion is assisted by the simultaneous diffusion of a language model representation of the amino acid sequence. To ensure high physical plausibility of the denoised output backbone, multiple generative adversarial network (GAN)-style discriminators are used to provide additional losses in training. We have computationally evaluated SCUBA-D by applying structure prediction to amino acid sequences designed on the denoised backbones. The results suggest that SCUBA-D can generate high quality backbones from initial backbones that contain noises of various types or magnitudes, such as initial backbones coarsely sketched to follow certain overall shapes, or initial backbones comprising well-defined functional sites connected by unknown scaffolding regions." @default.
- W4311924788 created "2023-01-02" @default.
- W4311924788 creator A5028617332 @default.
- W4311924788 creator A5037824478 @default.
- W4311924788 creator A5058269550 @default.
- W4311924788 date "2022-12-19" @default.
- W4311924788 modified "2023-10-15" @default.
- W4311924788 title "De novo protein backbone generation based on diffusion with structured priors and adversarial training" @default.
- W4311924788 cites W1969644422 @default.
- W4311924788 cites W2085497102 @default.
- W4311924788 cites W2519539312 @default.
- W4311924788 cites W2548003600 @default.
- W4311924788 cites W2968494487 @default.
- W4311924788 cites W2997234557 @default.
- W4311924788 cites W3010339412 @default.
- W4311924788 cites W3087655841 @default.
- W4311924788 cites W3096831136 @default.
- W4311924788 cites W3106745904 @default.
- W4311924788 cites W3146944767 @default.
- W4311924788 cites W3177828909 @default.
- W4311924788 cites W3186179742 @default.
- W4311924788 cites W3194906223 @default.
- W4311924788 cites W3201100749 @default.
- W4311924788 cites W3216341763 @default.
- W4311924788 cites W4205953903 @default.
- W4311924788 cites W4210301928 @default.
- W4311924788 cites W4210922059 @default.
- W4311924788 cites W4223581484 @default.
- W4311924788 cites W4224066120 @default.
- W4311924788 cites W4283390570 @default.
- W4311924788 cites W4283588088 @default.
- W4311924788 cites W4286488966 @default.
- W4311924788 cites W4296032638 @default.
- W4311924788 doi "https://doi.org/10.1101/2022.12.17.520847" @default.
- W4311924788 hasPublicationYear "2022" @default.
- W4311924788 type Work @default.
- W4311924788 citedByCount "0" @default.
- W4311924788 crossrefType "posted-content" @default.
- W4311924788 hasAuthorship W4311924788A5028617332 @default.
- W4311924788 hasAuthorship W4311924788A5037824478 @default.
- W4311924788 hasAuthorship W4311924788A5058269550 @default.
- W4311924788 hasBestOaLocation W43119247881 @default.
- W4311924788 hasConcept C107673813 @default.
- W4311924788 hasConcept C111472728 @default.
- W4311924788 hasConcept C11413529 @default.
- W4311924788 hasConcept C115961682 @default.
- W4311924788 hasConcept C121332964 @default.
- W4311924788 hasConcept C138885662 @default.
- W4311924788 hasConcept C153180895 @default.
- W4311924788 hasConcept C154945302 @default.
- W4311924788 hasConcept C163294075 @default.
- W4311924788 hasConcept C177769412 @default.
- W4311924788 hasConcept C2779530757 @default.
- W4311924788 hasConcept C2988773926 @default.
- W4311924788 hasConcept C39890363 @default.
- W4311924788 hasConcept C41008148 @default.
- W4311924788 hasConcept C69357855 @default.
- W4311924788 hasConcept C76155785 @default.
- W4311924788 hasConcept C88796919 @default.
- W4311924788 hasConcept C97355855 @default.
- W4311924788 hasConceptScore W4311924788C107673813 @default.
- W4311924788 hasConceptScore W4311924788C111472728 @default.
- W4311924788 hasConceptScore W4311924788C11413529 @default.
- W4311924788 hasConceptScore W4311924788C115961682 @default.
- W4311924788 hasConceptScore W4311924788C121332964 @default.
- W4311924788 hasConceptScore W4311924788C138885662 @default.
- W4311924788 hasConceptScore W4311924788C153180895 @default.
- W4311924788 hasConceptScore W4311924788C154945302 @default.
- W4311924788 hasConceptScore W4311924788C163294075 @default.
- W4311924788 hasConceptScore W4311924788C177769412 @default.
- W4311924788 hasConceptScore W4311924788C2779530757 @default.
- W4311924788 hasConceptScore W4311924788C2988773926 @default.
- W4311924788 hasConceptScore W4311924788C39890363 @default.
- W4311924788 hasConceptScore W4311924788C41008148 @default.
- W4311924788 hasConceptScore W4311924788C69357855 @default.
- W4311924788 hasConceptScore W4311924788C76155785 @default.
- W4311924788 hasConceptScore W4311924788C88796919 @default.
- W4311924788 hasConceptScore W4311924788C97355855 @default.
- W4311924788 hasLocation W43119247881 @default.
- W4311924788 hasOpenAccess W4311924788 @default.
- W4311924788 hasPrimaryLocation W43119247881 @default.
- W4311924788 hasRelatedWork W2982455199 @default.
- W4311924788 hasRelatedWork W3012096086 @default.
- W4311924788 hasRelatedWork W3024390022 @default.
- W4311924788 hasRelatedWork W3139475326 @default.
- W4311924788 hasRelatedWork W3156291593 @default.
- W4311924788 hasRelatedWork W3178813832 @default.
- W4311924788 hasRelatedWork W3198184493 @default.
- W4311924788 hasRelatedWork W4313479464 @default.
- W4311924788 hasRelatedWork W4316035501 @default.
- W4311924788 hasRelatedWork W4367722749 @default.
- W4311924788 isParatext "false" @default.
- W4311924788 isRetracted "false" @default.
- W4311924788 workType "article" @default.