Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311938733> ?p ?o ?g. }
- W4311938733 abstract "It is well-documented that systemic lupus erythematosus (SLE) is associated with dementia. However, the genetic causality of this association remains unclear. Mendelian randomization (MR) was used to investigate the potential causal relationship between SLE and dementia risk in the current study.We selected 45 single nucleotide polymorphisms (SNPs) associated with SLE from publicly available genome-wide association studies (GWAS). Summary level statistics were obtained from the dementia GWAS database. MR estimates were performed using the inverse variance weighted (IVW) method, MR-Egger method and weighted median (WM) method. Cochran's Q test, the intercept of MR-Egger, MR-Pleiotropy Residual Sum and Outlier method, leave-one-out analysis and funnel plot were applied for sensitivity analyses.No significant causal association was found between SLE and any type of dementia, including Alzheimer's disease, vascular dementia, frontotemporal dementia, and dementia with Lewy bodies. These findings were robust across several sensitivity analyses.Overall, our findings do not support a causal association between SLE and dementia risk." @default.
- W4311938733 created "2023-01-02" @default.
- W4311938733 creator A5000194814 @default.
- W4311938733 creator A5014356738 @default.
- W4311938733 creator A5019683124 @default.
- W4311938733 creator A5027560026 @default.
- W4311938733 creator A5065243999 @default.
- W4311938733 creator A5072237935 @default.
- W4311938733 creator A5091422346 @default.
- W4311938733 date "2022-12-08" @default.
- W4311938733 modified "2023-09-30" @default.
- W4311938733 title "Causal association between systemic lupus erythematosus and the risk of dementia: A Mendelian randomization study" @default.
- W4311938733 cites W157151089 @default.
- W4311938733 cites W1871783318 @default.
- W4311938733 cites W1972696558 @default.
- W4311938733 cites W1991221279 @default.
- W4311938733 cites W1993894887 @default.
- W4311938733 cites W2019169142 @default.
- W4311938733 cites W2027911783 @default.
- W4311938733 cites W2035242178 @default.
- W4311938733 cites W2049174175 @default.
- W4311938733 cites W2051263083 @default.
- W4311938733 cites W2051647623 @default.
- W4311938733 cites W2065811496 @default.
- W4311938733 cites W2065920434 @default.
- W4311938733 cites W2103783427 @default.
- W4311938733 cites W2104673530 @default.
- W4311938733 cites W2105658598 @default.
- W4311938733 cites W2112203259 @default.
- W4311938733 cites W2113699335 @default.
- W4311938733 cites W2120786099 @default.
- W4311938733 cites W2129657984 @default.
- W4311938733 cites W2147457110 @default.
- W4311938733 cites W2149450071 @default.
- W4311938733 cites W2163461405 @default.
- W4311938733 cites W2163749231 @default.
- W4311938733 cites W2163955717 @default.
- W4311938733 cites W2317242858 @default.
- W4311938733 cites W2324862792 @default.
- W4311938733 cites W2329711941 @default.
- W4311938733 cites W2342897939 @default.
- W4311938733 cites W2416912299 @default.
- W4311938733 cites W2488281607 @default.
- W4311938733 cites W2528302205 @default.
- W4311938733 cites W2538345017 @default.
- W4311938733 cites W2561536790 @default.
- W4311938733 cites W2594502459 @default.
- W4311938733 cites W2607741101 @default.
- W4311938733 cites W2623256037 @default.
- W4311938733 cites W2759782656 @default.
- W4311938733 cites W2767736718 @default.
- W4311938733 cites W2768238915 @default.
- W4311938733 cites W2803072880 @default.
- W4311938733 cites W2805872240 @default.
- W4311938733 cites W2805983714 @default.
- W4311938733 cites W2807443196 @default.
- W4311938733 cites W2811372437 @default.
- W4311938733 cites W2818417770 @default.
- W4311938733 cites W2967130347 @default.
- W4311938733 cites W3020059669 @default.
- W4311938733 cites W3022548816 @default.
- W4311938733 cites W3032685893 @default.
- W4311938733 cites W3082986568 @default.
- W4311938733 cites W3084970060 @default.
- W4311938733 cites W3104522300 @default.
- W4311938733 cites W3106725626 @default.
- W4311938733 cites W3128153416 @default.
- W4311938733 cites W3135630778 @default.
- W4311938733 cites W3210570897 @default.
- W4311938733 cites W3211008043 @default.
- W4311938733 cites W4224222193 @default.
- W4311938733 cites W4229072442 @default.
- W4311938733 cites W4231495302 @default.
- W4311938733 cites W4232663087 @default.
- W4311938733 cites W4245052156 @default.
- W4311938733 cites W4292232933 @default.
- W4311938733 doi "https://doi.org/10.3389/fimmu.2022.1063110" @default.
- W4311938733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36569847" @default.
- W4311938733 hasPublicationYear "2022" @default.
- W4311938733 type Work @default.
- W4311938733 citedByCount "1" @default.
- W4311938733 countsByYear W43119387332023 @default.
- W4311938733 crossrefType "journal-article" @default.
- W4311938733 hasAuthorship W4311938733A5000194814 @default.
- W4311938733 hasAuthorship W4311938733A5014356738 @default.
- W4311938733 hasAuthorship W4311938733A5019683124 @default.
- W4311938733 hasAuthorship W4311938733A5027560026 @default.
- W4311938733 hasAuthorship W4311938733A5065243999 @default.
- W4311938733 hasAuthorship W4311938733A5072237935 @default.
- W4311938733 hasAuthorship W4311938733A5091422346 @default.
- W4311938733 hasBestOaLocation W43119387331 @default.
- W4311938733 hasConcept C104317684 @default.
- W4311938733 hasConcept C106208931 @default.
- W4311938733 hasConcept C126322002 @default.
- W4311938733 hasConcept C127716648 @default.
- W4311938733 hasConcept C135763542 @default.
- W4311938733 hasConcept C143998085 @default.
- W4311938733 hasConcept C153209595 @default.
- W4311938733 hasConcept C186413461 @default.
- W4311938733 hasConcept C26207810 @default.