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- W4311944622 abstract "Adult-type diffuse gliomas represent a group of highly infiltrative central nervous system tumors with a prognosis that significantly varies depending on the specific subtype and histological grade. Traditionally, adult-type diffuse gliomas have been classified based on their morphological features with a great interobserver variability and discrepancy in patient survival even within the same histological grade. Over the last few decades, advances in molecular profiling have drastically changed the diagnostic approach and classification of brain tumors leading to the development of an integrated morphological and molecular classification endowed with a more clinically relevant value. These concepts were largely anticipated in the revised fourth-edition of WHO classification of central nervous system tumors published in 2016. The fifth-edition (WHO 2021) moved molecular diagnostics forward into a full integration of molecular parameters with the histological features into an integrative diagnostic approach. Diagnosis of adult type diffuse gliomas, IDH mutant and IDH-wildtype has been simplified by introducing revised diagnostic and grading criteria. In this review, we will discuss the most recent updates to the classification of adult-type diffuse gliomas and summarize the essential diagnostic keys providing a practical guidance to pathologists." @default.
- W4311944622 created "2023-01-02" @default.
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- W4311944622 creator A5066199348 @default.
- W4311944622 date "2022-12-01" @default.
- W4311944622 modified "2023-10-13" @default.
- W4311944622 title "Adult type diffuse gliomas in the new 2021 WHO Classification" @default.
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- W4311944622 doi "https://doi.org/10.32074/1591-951x-823" @default.
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