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- W4311957450 abstract "Background: Fungal keratitis is an acute or chronic inflammation of the cornea caused by fungi. The main treatment for fungal keratitis is Natamycin 5%. Disadvantages of natamycin are its poor penetration and increased resistance due to fungi which lower the level of ergosterol in its wall. Purpose: Investigates the effect of bromelain, zingibain and papain on LOX-1 receptors in fungal keratitis caused by Aspergillus fumigatus. Result: The LOX-1 receptor with bromelain produces a binding energy value of -827.8. While the results of docking LOX-1 receptors with zingibain resulted in a binding energy value of -1096.3. Furthermore, the results of docking the LOX-1 receptor with papain resulted in a binding energy value of -900.0. Conclusion: zingibain has the highest potency among the three enzymes Papain as an Alternative Medicine for Fungal Keratitis" @default.
- W4311957450 created "2023-01-03" @default.
- W4311957450 creator A5074449359 @default.
- W4311957450 date "2022-12-09" @default.
- W4311957450 modified "2023-09-30" @default.
- W4311957450 title "In Silico: Analysis of the Potential of Bromelain, Zingibain and Papain as an Alternative Medicine for Fungal Keratitis" @default.
- W4311957450 doi "https://doi.org/10.47191/ijpbms/v2-i12-05" @default.
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