FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311966861> ?p ?o ?g. }

• W4311966861 endingPage "160819" @default.
• W4311966861 startingPage "160819" @default.
• W4311966861 abstract "Neodymium oxide nanoparticles (NPs-Nd2O3) are increasingly being used in industry and biomedicine, causing adverse health effects such as lung disease. However, the underlying molecular mechanisms controlling these adverse consequences are unknown at present. In this study, a human bronchial epithelial cell line (16HBE) was exposed to increasing concentrations of NPs-Nd2O3, and Sprague-Dawley rats were treated with NPs-Nd2O3 by intratracheal instillation. We found that NPs-Nd2O3 exposure induced DNA damage and down-regulated levels of circular RNA (circRNA) circ_002363 in 16HBE cells as well as in rat lung tissue. We also observed that circ_002363 levels in the serum of workers employed in the production of NPs-Nd2O3 diminished as the work time progressed, suggesting that circ_002363 may be a potential biomarker of lung injury. Functional experiments showed that circ_002363 significantly inhibited DNA damage induced by NPs-Nd2O3. RNA pull-down and western blot assays found that circ_002363 interacted with proteins PARP1/Ku70/Ku80/Rad50, which are critical participants in non-homologous end-joining (NHEJ) DNA repair. Moreover, we found that formation of circ_002363 was regulated by the RNA binding protein Breast Carcinoma Amplified Sequence 2 (BCAS2). The BCAS2 protein affected circ_002363 expression through interaction with Pre-DNA2, the host gene of circ_002363, in NPs-Nd2O3−exposed 16HBE cells. In conclusion, our findings show first that circ_002363, which is regulated by BCAS2, acts as regulator of DNA damage via the NHEJ pathway. These results enhance our understanding of the regulatory mechanisms controlling the actions of circular RNAs and highlight the relationship between genetics and epigenetics in the development of diseases following exposure to environmental chemicals." @default.
• W4311966861 created "2023-01-03" @default.
• W4311966861 creator A5017360203 @default.
• W4311966861 creator A5052354691 @default.
• W4311966861 creator A5059483904 @default.
• W4311966861 creator A5075695776 @default.
• W4311966861 creator A5082241181 @default.
• W4311966861 creator A5090875147 @default.
• W4311966861 date "2023-03-01" @default.
• W4311966861 modified "2023-10-13" @default.
• W4311966861 title "Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair" @default.
• W4311966861 cites W1970681395 @default.
• W4311966861 cites W1988941988 @default.
• W4311966861 cites W1989807750 @default.
• W4311966861 cites W1994416042 @default.
• W4311966861 cites W2000660820 @default.
• W4311966861 cites W2007784993 @default.
• W4311966861 cites W2015101132 @default.
• W4311966861 cites W2034485370 @default.
• W4311966861 cites W2044924686 @default.
• W4311966861 cites W2046337791 @default.
• W4311966861 cites W2060665522 @default.
• W4311966861 cites W2090374150 @default.
• W4311966861 cites W2119265369 @default.
• W4311966861 cites W2145200068 @default.
• W4311966861 cites W2284415752 @default.
• W4311966861 cites W2614952490 @default.
• W4311966861 cites W2735818676 @default.
• W4311966861 cites W2759676893 @default.
• W4311966861 cites W2771049305 @default.
• W4311966861 cites W2795227812 @default.
• W4311966861 cites W2802349403 @default.
• W4311966861 cites W2899325684 @default.
• W4311966861 cites W2906120852 @default.
• W4311966861 cites W2906592796 @default.
• W4311966861 cites W2909162709 @default.
• W4311966861 cites W2911504883 @default.
• W4311966861 cites W2922871784 @default.
• W4311966861 cites W2955620588 @default.
• W4311966861 cites W3005916720 @default.
• W4311966861 cites W3039685517 @default.
• W4311966861 cites W3101095331 @default.
• W4311966861 cites W3118545123 @default.
• W4311966861 cites W3174754627 @default.
• W4311966861 cites W3188528058 @default.
• W4311966861 cites W3209049566 @default.
• W4311966861 cites W3209574221 @default.
• W4311966861 cites W3213214654 @default.
• W4311966861 cites W4200478364 @default.
• W4311966861 cites W4210287910 @default.
• W4311966861 cites W4210490077 @default.
• W4311966861 cites W4223917195 @default.
• W4311966861 doi "https://doi.org/10.1016/j.scitotenv.2022.160819" @default.
• W4311966861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36526188" @default.
• W4311966861 hasPublicationYear "2023" @default.
• W4311966861 type Work @default.
• W4311966861 citedByCount "2" @default.
• W4311966861 countsByYear W43119668612023 @default.
• W4311966861 crossrefType "journal-article" @default.
• W4311966861 hasAuthorship W4311966861A5017360203 @default.
• W4311966861 hasAuthorship W4311966861A5052354691 @default.
• W4311966861 hasAuthorship W4311966861A5059483904 @default.
• W4311966861 hasAuthorship W4311966861A5075695776 @default.
• W4311966861 hasAuthorship W4311966861A5082241181 @default.
• W4311966861 hasAuthorship W4311966861A5090875147 @default.
• W4311966861 hasConcept C104317684 @default.
• W4311966861 hasConcept C134935766 @default.
• W4311966861 hasConcept C143425029 @default.
• W4311966861 hasConcept C153911025 @default.
• W4311966861 hasConcept C185592680 @default.
• W4311966861 hasConcept C2780919815 @default.
• W4311966861 hasConcept C552990157 @default.
• W4311966861 hasConcept C55493867 @default.
• W4311966861 hasConcept C67705224 @default.
• W4311966861 hasConcept C86803240 @default.
• W4311966861 hasConcept C95444343 @default.
• W4311966861 hasConceptScore W4311966861C104317684 @default.
• W4311966861 hasConceptScore W4311966861C134935766 @default.
• W4311966861 hasConceptScore W4311966861C143425029 @default.
• W4311966861 hasConceptScore W4311966861C153911025 @default.
• W4311966861 hasConceptScore W4311966861C185592680 @default.
• W4311966861 hasConceptScore W4311966861C2780919815 @default.
• W4311966861 hasConceptScore W4311966861C552990157 @default.
• W4311966861 hasConceptScore W4311966861C55493867 @default.
• W4311966861 hasConceptScore W4311966861C67705224 @default.
• W4311966861 hasConceptScore W4311966861C86803240 @default.
• W4311966861 hasConceptScore W4311966861C95444343 @default.
• W4311966861 hasFunder F4320321001 @default.
• W4311966861 hasLocation W43119668611 @default.
• W4311966861 hasLocation W43119668612 @default.
• W4311966861 hasOpenAccess W4311966861 @default.
• W4311966861 hasPrimaryLocation W43119668611 @default.
• W4311966861 hasRelatedWork W190305305 @default.
• W4311966861 hasRelatedWork W1976736675 @default.
• W4311966861 hasRelatedWork W2002473487 @default.
• W4311966861 hasRelatedWork W2045802588 @default.
• W4311966861 hasRelatedWork W2065618984 @default.
• W4311966861 hasRelatedWork W2130776990 @default.

• next