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- W4311974411 endingPage "7319" @default.
- W4311974411 startingPage "7319" @default.
- W4311974411 abstract "Cell therapies are an emergent treatment for cerebral palsy (CP) with promising evidence demonstrating efficacy for improving gross motor function. However, families value improvements in a range of domains following intervention and the non-motor symptoms, comorbidities and complications of CP can potentially be targeted by cell therapies. We conducted a scoping review to describe all outcomes that have been reported in cell therapy studies for CP to date, and to examine what instruments were used to capture these. Through a systematic search we identified 54 studies comprising 2066 participants that were treated with a range of cell therapy interventions. We categorized the reported 53 unique outcome instruments and additional descriptive measures into 10 categories and 12 sub-categories. Movement and Posture was the most frequently reported outcome category, followed by Safety, however Quality of Life, and various prevalent comorbidities and complications of CP were infrequently reported. Notably, many outcome instruments used do not have evaluative properties and thus are not suitable for measuring change following intervention. We provide a number of recommendations to ensure that future trials generate high-quality outcome data that is aligned with the priorities of the CP community." @default.
- W4311974411 created "2023-01-03" @default.
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- W4311974411 date "2022-12-09" @default.
- W4311974411 modified "2023-10-03" @default.
- W4311974411 title "Are We Getting It Right? A Scoping Review of Outcomes Reported in Cell Therapy Clinical Studies for Cerebral Palsy" @default.
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- W4311974411 doi "https://doi.org/10.3390/jcm11247319" @default.
- W4311974411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36555936" @default.
- W4311974411 hasPublicationYear "2022" @default.