FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4311992938> ?p ?o ?g. }

• W4311992938 abstract "Abstract Background: Alpha-1-antitrypsin deficient (AATD) individuals are prone to develop early age of onset chronic obstructive pulmonary disease (COPD) which is more severe than non-genetic COPD. In this study, we investigated the characteristics of lower respiratory tract inflammation in AATD individuals prior to the onset of clinically significant COPD. Methods: Bronchoalveolar lavage was performed on 22 AATD individuals with normal lung function and 14 healthy individuals. Cell counts and concentrations of proteases, alpha-1-antitrypsin, proinflammatory cytokines, and leukotriene B4 were determined in the bronchoalveolar lavage fluid from AATD and healthy individuals. In order to determine the characteristics of airway inflammation in this cohort, we also analyzed immune cell components of the large airways from bronchial biopsies using immunohistochemistry in both study subjects. Finally, we made comparisons between airway inflammation and lung function rate of decline using four repeated lung function tests over one year in AATD individuals. Results: AATD individuals with normal lung function had significantly higher neutrophil counts, levels of proteases, IL-8, IL-6, IL-1b, and leukotriene B4 in their epithelial lining fluid compared to control subjects. A positive correlation was noted between the levels of IL-8, neutrophils, and concentration of neutrophil elastase in epithelial lining fluid of AATD individuals. AATD individuals also showed a negative correlation of baseline FEV 1 with neutrophil count, neutrophil elastase, and cytokine levels in epithelial lining fluid. In addition, we found that the airways of AATD individuals have increased lymphocytes, macrophages, neutrophils, and mast cells in epithelial lining fluid compared to control subjects. Conclusion: Inflammation is present in the lower respiratory tract and airways of AATD individuals despite having normal lung function. A declining trend was also noticed in the lung function of AATD individuals which was correlated with inflammatory phenotype of their lower respiratory tract. This results provide new evidence for the presence of early inflammation in the lungs of AATD individuals. This suggests that early anti-inflammatory therapies may be a potential strategy to prevent progression of lung disease in individuals with AATD." @default.
• W4311992938 created "2023-01-03" @default.
• W4311992938 creator A5039665005 @default.
• W4311992938 creator A5046729821 @default.
• W4311992938 creator A5057923691 @default.
• W4311992938 creator A5065487837 @default.
• W4311992938 creator A5073945399 @default.
• W4311992938 date "2022-12-20" @default.
• W4311992938 modified "2023-10-15" @default.
• W4311992938 title "Lung Inflammation in Alpha-1-Antitrypsin Deficient Individuals with Normal Lung Function" @default.
• W4311992938 cites W1775181078 @default.
• W4311992938 cites W1967294645 @default.
• W4311992938 cites W1969397352 @default.
• W4311992938 cites W1971141144 @default.
• W4311992938 cites W1993347912 @default.
• W4311992938 cites W2013065585 @default.
• W4311992938 cites W2015373555 @default.
• W4311992938 cites W2024428337 @default.
• W4311992938 cites W2031333232 @default.
• W4311992938 cites W2033829453 @default.
• W4311992938 cites W2060301685 @default.
• W4311992938 cites W2062428707 @default.
• W4311992938 cites W2074863064 @default.
• W4311992938 cites W2077511906 @default.
• W4311992938 cites W2078297752 @default.
• W4311992938 cites W2079884348 @default.
• W4311992938 cites W2088117265 @default.
• W4311992938 cites W2088888695 @default.
• W4311992938 cites W2096445205 @default.
• W4311992938 cites W2096498639 @default.
• W4311992938 cites W2097410604 @default.
• W4311992938 cites W2109152260 @default.
• W4311992938 cites W2109254089 @default.
• W4311992938 cites W2112687518 @default.
• W4311992938 cites W2117837864 @default.
• W4311992938 cites W2122278678 @default.
• W4311992938 cites W2135826161 @default.
• W4311992938 cites W2149043719 @default.
• W4311992938 cites W2162572357 @default.
• W4311992938 cites W2163496983 @default.
• W4311992938 cites W2182355171 @default.
• W4311992938 cites W2398633376 @default.
• W4311992938 cites W2525566675 @default.
• W4311992938 cites W2601839973 @default.
• W4311992938 cites W2773049281 @default.
• W4311992938 cites W2793811615 @default.
• W4311992938 cites W2946333335 @default.
• W4311992938 cites W3003943436 @default.
• W4311992938 cites W3047284551 @default.
• W4311992938 cites W3083709377 @default.
• W4311992938 cites W3154139182 @default.
• W4311992938 cites W4230184052 @default.
• W4311992938 doi "https://doi.org/10.21203/rs.3.rs-2378966/v1" @default.
• W4311992938 hasPublicationYear "2022" @default.
• W4311992938 type Work @default.
• W4311992938 citedByCount "0" @default.
• W4311992938 crossrefType "posted-content" @default.
• W4311992938 hasAuthorship W4311992938A5039665005 @default.
• W4311992938 hasAuthorship W4311992938A5046729821 @default.
• W4311992938 hasAuthorship W4311992938A5057923691 @default.
• W4311992938 hasAuthorship W4311992938A5065487837 @default.
• W4311992938 hasAuthorship W4311992938A5073945399 @default.
• W4311992938 hasBestOaLocation W43119929381 @default.
• W4311992938 hasConcept C126322002 @default.
• W4311992938 hasConcept C142724271 @default.
• W4311992938 hasConcept C164027704 @default.
• W4311992938 hasConcept C181199279 @default.
• W4311992938 hasConcept C203014093 @default.
• W4311992938 hasConcept C2776317360 @default.
• W4311992938 hasConcept C2776780178 @default.
• W4311992938 hasConcept C2776914184 @default.
• W4311992938 hasConcept C2777714996 @default.
• W4311992938 hasConcept C2777961210 @default.
• W4311992938 hasConcept C2780535462 @default.
• W4311992938 hasConcept C2781044401 @default.
• W4311992938 hasConcept C55493867 @default.
• W4311992938 hasConcept C71924100 @default.
• W4311992938 hasConcept C75603125 @default.
• W4311992938 hasConcept C86803240 @default.
• W4311992938 hasConceptScore W4311992938C126322002 @default.
• W4311992938 hasConceptScore W4311992938C142724271 @default.
• W4311992938 hasConceptScore W4311992938C164027704 @default.
• W4311992938 hasConceptScore W4311992938C181199279 @default.
• W4311992938 hasConceptScore W4311992938C203014093 @default.
• W4311992938 hasConceptScore W4311992938C2776317360 @default.
• W4311992938 hasConceptScore W4311992938C2776780178 @default.
• W4311992938 hasConceptScore W4311992938C2776914184 @default.
• W4311992938 hasConceptScore W4311992938C2777714996 @default.
• W4311992938 hasConceptScore W4311992938C2777961210 @default.
• W4311992938 hasConceptScore W4311992938C2780535462 @default.
• W4311992938 hasConceptScore W4311992938C2781044401 @default.
• W4311992938 hasConceptScore W4311992938C55493867 @default.
• W4311992938 hasConceptScore W4311992938C71924100 @default.
• W4311992938 hasConceptScore W4311992938C75603125 @default.
• W4311992938 hasConceptScore W4311992938C86803240 @default.
• W4311992938 hasLocation W43119929381 @default.
• W4311992938 hasOpenAccess W4311992938 @default.
• W4311992938 hasPrimaryLocation W43119929381 @default.
• W4311992938 hasRelatedWork W1993072895 @default.
• W4311992938 hasRelatedWork W2002626376 @default.

• next