Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312003133> ?p ?o ?g. }
- W4312003133 abstract "The adrenomedullary chromaffin cell transduces chemical messages into outputs that regulate end organ function throughout the periphery. At least two important neurotransmitters are released by innervating preganglionic neurons to stimulate exocytosis in the chromaffin cell-acetylcholine (ACh) and pituitary adenylate cyclase activating polypeptide (PACAP). Although PACAP is widely acknowledged as an important secretagogue in this system, the pathway coupling PACAP stimulation to chromaffin cell secretion is poorly understood. The goal of this study is to address this knowledge gap. Here, it is shown that PACAP activates a Gαs-coupled pathway that must signal through phospholipase C ε (PLCε) to drive Ca2+ entry and exocytosis. PACAP stimulation causes a complex pattern of Ca2+ signals in chromaffin cells, leading to a sustained secretory response that is kinetically distinct from the form stimulated by ACh. Exocytosis caused by PACAP is associated with slower release of peptide cargo than exocytosis stimulated by ACh. Importantly, only the secretory response to PACAP, not ACh, is eliminated in cells lacking PLCε expression. The data show that ACh and PACAP, acting through distinct signaling pathways, enable nuanced and variable secretory outputs from chromaffin cells." @default.
- W4312003133 created "2023-01-03" @default.
- W4312003133 creator A5002671842 @default.
- W4312003133 creator A5005137674 @default.
- W4312003133 creator A5022375777 @default.
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- W4312003133 creator A5080213099 @default.
- W4312003133 creator A5082353619 @default.
- W4312003133 creator A5087088078 @default.
- W4312003133 date "2022-12-20" @default.
- W4312003133 modified "2023-10-16" @default.
- W4312003133 title "PACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells" @default.
- W4312003133 cites W1147884579 @default.
- W4312003133 cites W121899253 @default.
- W4312003133 cites W1484670943 @default.
- W4312003133 cites W1489597780 @default.
- W4312003133 cites W1492821183 @default.
- W4312003133 cites W1550711041 @default.
- W4312003133 cites W1568931203 @default.
- W4312003133 cites W1584902624 @default.
- W4312003133 cites W1763822794 @default.
- W4312003133 cites W1965213613 @default.
- W4312003133 cites W1970186130 @default.
- W4312003133 cites W1975767206 @default.
- W4312003133 cites W1977286827 @default.
- W4312003133 cites W1978220518 @default.
- W4312003133 cites W1979067492 @default.
- W4312003133 cites W1981385111 @default.
- W4312003133 cites W1981423842 @default.
- W4312003133 cites W1981746120 @default.
- W4312003133 cites W1981968644 @default.
- W4312003133 cites W1989328054 @default.
- W4312003133 cites W1996024251 @default.
- W4312003133 cites W2000243870 @default.
- W4312003133 cites W2004604151 @default.
- W4312003133 cites W2017971979 @default.
- W4312003133 cites W2018234159 @default.
- W4312003133 cites W2018372068 @default.
- W4312003133 cites W2024016443 @default.
- W4312003133 cites W2024870161 @default.
- W4312003133 cites W2024958741 @default.
- W4312003133 cites W2033312166 @default.
- W4312003133 cites W2035714598 @default.
- W4312003133 cites W2036053907 @default.
- W4312003133 cites W2040054170 @default.
- W4312003133 cites W2042572088 @default.
- W4312003133 cites W2044560098 @default.
- W4312003133 cites W2047101025 @default.
- W4312003133 cites W2053960727 @default.
- W4312003133 cites W2057457093 @default.
- W4312003133 cites W2059335175 @default.
- W4312003133 cites W2068628710 @default.
- W4312003133 cites W2068742213 @default.
- W4312003133 cites W2069862757 @default.
- W4312003133 cites W2073831388 @default.
- W4312003133 cites W2075919096 @default.
- W4312003133 cites W2080092859 @default.
- W4312003133 cites W2092134407 @default.
- W4312003133 cites W2102649799 @default.
- W4312003133 cites W2103317206 @default.
- W4312003133 cites W2104651163 @default.
- W4312003133 cites W2124678769 @default.
- W4312003133 cites W2126940622 @default.
- W4312003133 cites W2130105549 @default.
- W4312003133 cites W2136095861 @default.
- W4312003133 cites W2137229430 @default.
- W4312003133 cites W2141260882 @default.
- W4312003133 cites W2147496208 @default.
- W4312003133 cites W2161127226 @default.
- W4312003133 cites W2161538035 @default.
- W4312003133 cites W2164233733 @default.
- W4312003133 cites W2170544100 @default.
- W4312003133 cites W2171241069 @default.
- W4312003133 cites W2242548875 @default.
- W4312003133 cites W2512605113 @default.
- W4312003133 cites W2513237461 @default.
- W4312003133 cites W2521585032 @default.
- W4312003133 cites W2579990257 @default.
- W4312003133 cites W2592359670 @default.
- W4312003133 cites W2731280167 @default.
- W4312003133 cites W2742422162 @default.
- W4312003133 cites W2753235039 @default.
- W4312003133 cites W2758751954 @default.
- W4312003133 cites W2758830467 @default.
- W4312003133 cites W2763317308 @default.
- W4312003133 cites W2792871254 @default.
- W4312003133 cites W2803294422 @default.
- W4312003133 cites W2888792363 @default.
- W4312003133 cites W2895743787 @default.
- W4312003133 cites W2902733023 @default.
- W4312003133 cites W2917072859 @default.
- W4312003133 cites W2962575658 @default.