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• W4312017951 abstract "Abstract Species range expansions are a common demographic history presenting populations with multiple evolutionary challenges. It is not yet fully understood if self-fertilization, which is often observed at species range edges, may create an evolutionary advantage against these challenges. Selfing provides reproductive reassurance to counter Allee effects and selfing may purge accumulated mutational burden due to founder events (expansion load) by further increasing homozygosity. We study how selfing impacts the accumulation of genetic load during range expansion via purging and/or speed of colonization. Using simulations, we disentangle inbreeding effects due to demography versus due to selfing and find that selfers expand faster, but still accumulate load, regardless of mating system. The severity of variants contributing to this load, however, differs across mating system: higher selfing rates purge large-effect recessive variants leaving a burden of smaller-effect alleles. We compare these predictions to the mixedmating plant Arabis alpina , using whole-genome sequences from refugial outcrossing populations versus expanded selfing populations. Empirical results indicate accumulation of expansion load along with evidence of purging in selfing populations, concordant with our simulations, and suggesting that while purging is a benefit of selfing evolving during range expansions, it is not sufficient to prevent load accumulation due to range expansion. Author Summary The geographic space that species occupy, i.e. the species range, is known to fluctuate over time due to changing environmental conditions. Since the most recent glaciation, many species have recolonized available habitat as the ice sheets melted, expanding their range. When populations at species range margins expand into newly available space, they suffer from an accumulation of deleterious alleles due to repeated founder effects. We study whether self-fertilization, which is considered an evolutionary deadend, can be favored under these expanding edge conditions. Selfing has two important effects: allowing for faster expansion due to reproductive assurance and purging recessive deleterious alleles by exposing them to selection as homozygotes. We use simulations to identify the impact of selfing on expanded populations and then compare these results to an empirical dataset to assess whether our predictions are met. We use the mixed-mating plant alpine rock-cress ( Arabis alpina ) since it has both expanded since the last glaciation and undergone a mating shift to selfing. We find that selfing does not prevent the accumulation of deleterious load, however purging does still act to remove the most severe variants, indicating that selfing provides this benefit during range expansions." @default.
• W4312017951 created "2023-01-03" @default.
• W4312017951 creator A5053458520 @default.
• W4312017951 creator A5066135268 @default.
• W4312017951 creator A5071169681 @default.
• W4312017951 date "2022-12-20" @default.
• W4312017951 modified "2023-10-11" @default.
• W4312017951 title "Purging due to self-fertilization does not prevent accumulation of expansion load" @default.
• W4312017951 cites W1528855089 @default.
• W4312017951 cites W1557252899 @default.
• W4312017951 cites W1569496099 @default.
• W4312017951 cites W1573669151 @default.
• W4312017951 cites W1828904010 @default.
• W4312017951 cites W1967161447 @default.
• W4312017951 cites W1980722139 @default.
• W4312017951 cites W2002882118 @default.
• W4312017951 cites W2005124552 @default.
• W4312017951 cites W2012294035 @default.
• W4312017951 cites W2025951068 @default.
• W4312017951 cites W2042135396 @default.
• W4312017951 cites W2051334294 @default.
• W4312017951 cites W2053064870 @default.
• W4312017951 cites W2054014123 @default.
• W4312017951 cites W2055880741 @default.
• W4312017951 cites W2058532318 @default.
• W4312017951 cites W2059748199 @default.
• W4312017951 cites W2062210712 @default.
• W4312017951 cites W2065035179 @default.
• W4312017951 cites W2065317320 @default.
• W4312017951 cites W2065998026 @default.
• W4312017951 cites W2067604808 @default.
• W4312017951 cites W2078990105 @default.
• W4312017951 cites W2082118159 @default.
• W4312017951 cites W2088157223 @default.
• W4312017951 cites W2093826686 @default.
• W4312017951 cites W2099461131 @default.
• W4312017951 cites W2103441770 @default.
• W4312017951 cites W2106578986 @default.
• W4312017951 cites W2109069692 @default.
• W4312017951 cites W2112357013 @default.
• W4312017951 cites W2113401798 @default.
• W4312017951 cites W2117314920 @default.
• W4312017951 cites W2118961269 @default.
• W4312017951 cites W2119444539 @default.
• W4312017951 cites W2125300654 @default.
• W4312017951 cites W2127588110 @default.
• W4312017951 cites W2128023973 @default.
• W4312017951 cites W2131271579 @default.
• W4312017951 cites W2135858501 @default.
• W4312017951 cites W2139477305 @default.
• W4312017951 cites W2142489493 @default.
• W4312017951 cites W2142777374 @default.
• W4312017951 cites W2143897290 @default.
• W4312017951 cites W2144466056 @default.
• W4312017951 cites W2147247464 @default.
• W4312017951 cites W2149354969 @default.
• W4312017951 cites W2152198622 @default.
• W4312017951 cites W2157132957 @default.
• W4312017951 cites W2161819299 @default.
• W4312017951 cites W2162758337 @default.
• W4312017951 cites W2166389618 @default.
• W4312017951 cites W2167243456 @default.
• W4312017951 cites W2217029310 @default.
• W4312017951 cites W2258930354 @default.
• W4312017951 cites W2432815617 @default.
• W4312017951 cites W2487069673 @default.
• W4312017951 cites W2581829599 @default.
• W4312017951 cites W2583479769 @default.
• W4312017951 cites W2639639281 @default.
• W4312017951 cites W2744032814 @default.
• W4312017951 cites W2783414932 @default.
• W4312017951 cites W2891165132 @default.
• W4312017951 cites W2908631883 @default.
• W4312017951 cites W2949207689 @default.
• W4312017951 cites W2949399278 @default.
• W4312017951 cites W2950006249 @default.
• W4312017951 cites W2950232895 @default.
• W4312017951 cites W2950771981 @default.
• W4312017951 cites W2951861529 @default.
• W4312017951 cites W2952313101 @default.
• W4312017951 cites W2953294771 @default.
• W4312017951 cites W3036478510 @default.
• W4312017951 cites W3119366910 @default.
• W4312017951 cites W3123129704 @default.
• W4312017951 cites W3123828571 @default.
• W4312017951 cites W3131055609 @default.
• W4312017951 cites W3199062838 @default.
• W4312017951 cites W3201662708 @default.
• W4312017951 cites W4236351289 @default.
• W4312017951 cites W4241415231 @default.
• W4312017951 cites W4241590452 @default.
• W4312017951 cites W4246609952 @default.
• W4312017951 cites W4255594308 @default.
• W4312017951 doi "https://doi.org/10.1101/2022.12.19.521096" @default.
• W4312017951 hasPublicationYear "2022" @default.
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