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Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312018995> ?p ?o ?g. }

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• W4312018995 abstract "Triplex nanostructures can be formed in vitro in the promoter region of DNA templates, and it is commonly accepted that these assemblies inhibit the transcription of the downstream genes. Herein, a proof of concept highlighting the possibility of the up- or downregulation of RNA transcription is presented. Hybrid DNA-RNA triplex nanostructures were rationally designed to produce bacterial transcription units with switchable promoters. The rate of RNA production was measured using the signal of a transcribed fluorescent RNA aptamer (i.e. Broccoli). Indeed, several designed bacterial promoters showed the ability of induced transcriptional inhibition, while other properly tailored sequences demonstrated switchable enhancement of transcriptional activity, representing an unprecedented feature to date. The use of RNA-regulated transcription units and fluorescent RNA aptamers as readouts will allow the realization of biocomputation circuits characterized by a strongly reduced set of components. Triplex forming RNA oligonucleotides are proposed as smart tools for transcriptional modulation and represent an alternative to current methods for producing logic gates using protein-based components." @default.
• W4312018995 created "2023-01-03" @default.
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• W4312018995 date "2022-12-09" @default.
• W4312018995 modified "2023-10-14" @default.
• W4312018995 title "Rational design of hybrid DNA–RNA triplex structures as modulators of transcriptional activity <i>in vitro</i>" @default.
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• W4312018995 doi "https://doi.org/10.1093/nar/gkac1131" @default.
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