Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312019802> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4312019802 endingPage "399" @default.
- W4312019802 startingPage "393" @default.
- W4312019802 abstract "Objective : Chiari II malformation (CM II) is still the main cause of severe morbidity and mortality in children with open neural tube defects (ONTDs). The goal of this study was to validate a CM II model in late-stage chick embryos with surgically induced ONTDs.Methods : To make the chick embryo model of ONTD, their neural tubes were opened for a length of 5–6 somites at the thoracic level in Hamburger and Hamilton stage 18 chick embryos (n=150). They were reincubated <i>in ovo</i>. up to a total age of 17–21 days. A total of 19 embryos survived and were assigned to either the postoperative day (POD) 14–15 group (n=6) or the POD 17–18 group (n=13). Magnetic resonance imaging (MRI) and histopathologic findings of embryo heads with spinal ONTDs were compared with age-matched normal chick embryos.Results : The chick embryos with ONTDs demonstrated definite and constant structural changes, such as downward displacement of the cerebellum to just above the foramen magnum and narrow and small cerebrospinal fluid spaces in the crowded small posterior fossa. These morphologic features were more prominent in the POD 17–18 group than in the POD 14–15 group.Conclusion : This is the first description of CM II with spinal ONTD in a late-stage chick embryo model with MRI and histopathological analysis. The morphological changes of the posterior fossa in this study mimic those of CM II associated with spinal ONTD in humans. This model will facilitate investigation of the pathogenesis of CM II." @default.
- W4312019802 created "2023-01-03" @default.
- W4312019802 creator A5015361222 @default.
- W4312019802 creator A5033045118 @default.
- W4312019802 creator A5062645264 @default.
- W4312019802 date "2023-07-01" @default.
- W4312019802 modified "2023-10-14" @default.
- W4312019802 title "Chiari Malformation with Surgically Induced Open Neural Tube Defect in Late Chick Embryos : Characterization by Magnetic Resonance Imaging and Histopathological Analysis" @default.
- W4312019802 cites W1964870255 @default.
- W4312019802 cites W1966662812 @default.
- W4312019802 cites W1971829011 @default.
- W4312019802 cites W1973125278 @default.
- W4312019802 cites W1999460242 @default.
- W4312019802 cites W2009046145 @default.
- W4312019802 cites W2026996919 @default.
- W4312019802 cites W2028720542 @default.
- W4312019802 cites W2052428745 @default.
- W4312019802 cites W2060950649 @default.
- W4312019802 cites W2065686315 @default.
- W4312019802 cites W2084952267 @default.
- W4312019802 cites W2089831500 @default.
- W4312019802 cites W2122551686 @default.
- W4312019802 cites W2140034535 @default.
- W4312019802 doi "https://doi.org/10.3340/jkns.2022.0144" @default.
- W4312019802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36537033" @default.
- W4312019802 hasPublicationYear "2023" @default.
- W4312019802 type Work @default.
- W4312019802 citedByCount "1" @default.
- W4312019802 countsByYear W43120198022023 @default.
- W4312019802 crossrefType "journal-article" @default.
- W4312019802 hasAuthorship W4312019802A5015361222 @default.
- W4312019802 hasAuthorship W4312019802A5033045118 @default.
- W4312019802 hasAuthorship W4312019802A5062645264 @default.
- W4312019802 hasBestOaLocation W43120198021 @default.
- W4312019802 hasConcept C105702510 @default.
- W4312019802 hasConcept C126838900 @default.
- W4312019802 hasConcept C142724271 @default.
- W4312019802 hasConcept C143409427 @default.
- W4312019802 hasConcept C196843134 @default.
- W4312019802 hasConcept C2776106272 @default.
- W4312019802 hasConcept C2777003008 @default.
- W4312019802 hasConcept C2779651940 @default.
- W4312019802 hasConcept C2780594696 @default.
- W4312019802 hasConcept C71924100 @default.
- W4312019802 hasConcept C86803240 @default.
- W4312019802 hasConcept C95444343 @default.
- W4312019802 hasConceptScore W4312019802C105702510 @default.
- W4312019802 hasConceptScore W4312019802C126838900 @default.
- W4312019802 hasConceptScore W4312019802C142724271 @default.
- W4312019802 hasConceptScore W4312019802C143409427 @default.
- W4312019802 hasConceptScore W4312019802C196843134 @default.
- W4312019802 hasConceptScore W4312019802C2776106272 @default.
- W4312019802 hasConceptScore W4312019802C2777003008 @default.
- W4312019802 hasConceptScore W4312019802C2779651940 @default.
- W4312019802 hasConceptScore W4312019802C2780594696 @default.
- W4312019802 hasConceptScore W4312019802C71924100 @default.
- W4312019802 hasConceptScore W4312019802C86803240 @default.
- W4312019802 hasConceptScore W4312019802C95444343 @default.
- W4312019802 hasFunder F4320321191 @default.
- W4312019802 hasIssue "4" @default.
- W4312019802 hasLocation W43120198021 @default.
- W4312019802 hasLocation W43120198022 @default.
- W4312019802 hasLocation W43120198023 @default.
- W4312019802 hasOpenAccess W4312019802 @default.
- W4312019802 hasPrimaryLocation W43120198021 @default.
- W4312019802 hasRelatedWork W1911668635 @default.
- W4312019802 hasRelatedWork W1966226189 @default.
- W4312019802 hasRelatedWork W1977031797 @default.
- W4312019802 hasRelatedWork W1985085222 @default.
- W4312019802 hasRelatedWork W2089831500 @default.
- W4312019802 hasRelatedWork W2160912785 @default.
- W4312019802 hasRelatedWork W2172144028 @default.
- W4312019802 hasRelatedWork W2793737781 @default.
- W4312019802 hasRelatedWork W4205217868 @default.
- W4312019802 hasRelatedWork W4312019802 @default.
- W4312019802 hasVolume "66" @default.
- W4312019802 isParatext "false" @default.
- W4312019802 isRetracted "false" @default.
- W4312019802 workType "article" @default.