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- W4312032637 endingPage "16032" @default.
- W4312032637 startingPage "15993" @default.
- W4312032637 abstract "Huntington’s disease (HD) is a progressive neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene (HTT). The new insights into HD’s cellular and molecular pathways have led to the identification of numerous potent small-molecule therapeutics for HD therapy. The field of HD-targeting small-molecule therapeutics is accelerating, and the approval of these therapeutics to combat HD may be expected in the near future. For instance, preclinical candidates such as naphthyridine-azaquinolone, AN1, AN2, CHDI-00484077, PRE084, EVP4593, and LOC14 have shown promise for further optimization to enter into HD clinical trials. This perspective aims to summarize the advent of small-molecule therapeutics at various stages of clinical development for HD therapy, emphasizing their structure and design, therapeutic effects, and specific mechanisms of action. Further, we have highlighted the key drivers involved in HD pathogenesis to provide insights into the basic principle for designing promising anti-HD therapeutic leads." @default.
- W4312032637 created "2023-01-04" @default.
- W4312032637 creator A5024174818 @default.
- W4312032637 creator A5052861994 @default.
- W4312032637 date "2022-12-09" @default.
- W4312032637 modified "2023-10-14" @default.
- W4312032637 title "The Emerging Landscape of Small-Molecule Therapeutics for the Treatment of Huntington’s Disease" @default.
- W4312032637 cites W1467973230 @default.
- W4312032637 cites W1482169712 @default.
- W4312032637 cites W1497938915 @default.
- W4312032637 cites W1505026345 @default.
- W4312032637 cites W1578813045 @default.
- W4312032637 cites W1852094985 @default.
- W4312032637 cites W1896472383 @default.
- W4312032637 cites W1925196301 @default.
- W4312032637 cites W1963750818 @default.
- W4312032637 cites W1964267616 @default.
- W4312032637 cites W1966721340 @default.
- W4312032637 cites W1966735516 @default.
- W4312032637 cites W1966906920 @default.
- W4312032637 cites W1967440435 @default.
- W4312032637 cites W1969083180 @default.
- W4312032637 cites W1970986383 @default.
- W4312032637 cites W1971242889 @default.
- W4312032637 cites W1971573841 @default.
- W4312032637 cites W1972891035 @default.
- W4312032637 cites W1974769584 @default.
- W4312032637 cites W1974888639 @default.
- W4312032637 cites W1979286873 @default.
- W4312032637 cites W1982138681 @default.
- W4312032637 cites W1983402821 @default.
- W4312032637 cites W1983435506 @default.
- W4312032637 cites W1985474993 @default.
- W4312032637 cites W1985723850 @default.
- W4312032637 cites W1988044873 @default.
- W4312032637 cites W1989113354 @default.
- W4312032637 cites W1990286385 @default.
- W4312032637 cites W1991603311 @default.
- W4312032637 cites W1995181798 @default.
- W4312032637 cites W1995970444 @default.
- W4312032637 cites W2000082537 @default.
- W4312032637 cites W2000486056 @default.
- W4312032637 cites W2003598238 @default.
- W4312032637 cites W2005927762 @default.
- W4312032637 cites W2006808229 @default.
- W4312032637 cites W2007578481 @default.
- W4312032637 cites W2007719003 @default.
- W4312032637 cites W2008332933 @default.
- W4312032637 cites W2010373677 @default.
- W4312032637 cites W2011089118 @default.
- W4312032637 cites W2014520750 @default.
- W4312032637 cites W2015902113 @default.
- W4312032637 cites W2016888445 @default.
- W4312032637 cites W2017901987 @default.
- W4312032637 cites W2018048294 @default.
- W4312032637 cites W2018829484 @default.
- W4312032637 cites W2018830049 @default.
- W4312032637 cites W2018928754 @default.
- W4312032637 cites W2019079031 @default.
- W4312032637 cites W2019634326 @default.
- W4312032637 cites W2019750712 @default.
- W4312032637 cites W2020096302 @default.
- W4312032637 cites W2020629976 @default.
- W4312032637 cites W2027275070 @default.
- W4312032637 cites W2027835288 @default.
- W4312032637 cites W2028917823 @default.
- W4312032637 cites W2031116457 @default.
- W4312032637 cites W2031170161 @default.
- W4312032637 cites W2032120877 @default.
- W4312032637 cites W2034823585 @default.
- W4312032637 cites W2034963123 @default.
- W4312032637 cites W2035796612 @default.
- W4312032637 cites W2037206353 @default.
- W4312032637 cites W2038054564 @default.
- W4312032637 cites W2039376206 @default.
- W4312032637 cites W2039513109 @default.
- W4312032637 cites W2040257581 @default.
- W4312032637 cites W2040308828 @default.
- W4312032637 cites W2040462263 @default.
- W4312032637 cites W2041626049 @default.
- W4312032637 cites W2041677049 @default.
- W4312032637 cites W2042254284 @default.
- W4312032637 cites W2044218944 @default.
- W4312032637 cites W2045647507 @default.
- W4312032637 cites W2046020624 @default.
- W4312032637 cites W2046063066 @default.
- W4312032637 cites W2048277695 @default.
- W4312032637 cites W2048520110 @default.
- W4312032637 cites W2049944681 @default.
- W4312032637 cites W2052970339 @default.
- W4312032637 cites W2055386134 @default.
- W4312032637 cites W2055583081 @default.
- W4312032637 cites W2058182560 @default.
- W4312032637 cites W2058634928 @default.
- W4312032637 cites W2060588252 @default.
- W4312032637 cites W2061930165 @default.
- W4312032637 cites W2062059213 @default.
- W4312032637 cites W2062483494 @default.