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- W4312039295 endingPage "e202201480" @default.
- W4312039295 startingPage "e202201480" @default.
- W4312039295 abstract "Leptospira bacteria comprise numerous species, several of which cause serious disease to a broad range of hosts including humans. These spirochetes exhibit large intraspecific variation, resulting in complex tabulations of serogroups/serovars that crisscross the species classification. Serovar identity, linked to biological/clinical phenotypes, depends on the structure of surface-exposed LPS. Many LPS biosynthesis–encoding genes reside within the chromosomic rfb gene cluster. However, the genetic basis of intraspecies variability is not fully understood, constraining diagnostics/typing methods to cumbersome serologic procedures. We now show that the gene content of the rfb cluster strongly correlates with Leptospira serovar designation. Whole-genome sequencing of pathogenic L. noguchii , including strains of different serogroups, reveals that the rfb cluster undergoes extensive horizontal gene transfer. The rfb clusters from several Leptospira species disclose a univocal correspondence between gene composition and serovar identity. This work paves the way to genetic typing of Leptospira serovars, and to pinpointing specific genes within the distinct rfb clusters, encoding host-specific virulence traits. Further research shall unveil the molecular mechanism of rfb transfer among Leptospira strains and species." @default.
- W4312039295 created "2023-01-04" @default.
- W4312039295 creator A5008309855 @default.
- W4312039295 creator A5019172062 @default.
- W4312039295 creator A5037526161 @default.
- W4312039295 creator A5044879826 @default.
- W4312039295 creator A5083751887 @default.
- W4312039295 creator A5085588413 @default.
- W4312039295 date "2022-12-09" @default.
- W4312039295 modified "2023-10-18" @default.
- W4312039295 title "Horizontal transfer of the<i>rfb</i>cluster in<i>Leptospira</i>is a genetic determinant of serovar identity" @default.
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- W4312039295 doi "https://doi.org/10.26508/lsa.202201480" @default.
- W4312039295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36622346" @default.
- W4312039295 hasPublicationYear "2022" @default.
- W4312039295 type Work @default.