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- W4312045304 abstract "Arteries and veins are lined by nonproliferating endothelial cells that play a critical role in regulating blood flow. Endothelial cells also regulate tissue perfusion, metabolite exchange, and thrombosis. It is thought that endothelial cells rely on ATP generated via glycolysis, rather than mitochondrial oxidative phosphorylation, to fuel each of these energy-demanding processes. However, endothelial metabolism has mainly been studied in the context of proliferative cells, and little is known about energy production in endothelial cells within the fully formed vascular wall. Using intact arteries isolated from rats and mice, we show that inhibiting mitochondrial respiration disrupts endothelial control of vascular tone. Basal, mechanically activated, and agonist-evoked calcium activity in intact artery endothelial cells are each prevented by inhibiting mitochondrial ATP synthesis. Agonist-evoked calcium activity was also inhibited by blocking the transport of pyruvate, the master fuel for mitochondrial energy production, through the mitochondrial pyruvate carrier. The role for mitochondria in endothelial cell energy production is independent of species, sex, or vascular bed. These data show that a mitochondrial ATP supply is necessary for calcium-dependent, nitric oxide-mediated endothelial control of vascular tone, and identifies the critical role of endothelial mitochondrial energy production in fueling perfused blood vessel function." @default.
- W4312045304 created "2023-01-04" @default.
- W4312045304 creator A5030229064 @default.
- W4312045304 creator A5043580762 @default.
- W4312045304 creator A5046143675 @default.
- W4312045304 creator A5046534291 @default.
- W4312045304 creator A5058980479 @default.
- W4312045304 date "2022-12-09" @default.
- W4312045304 modified "2023-10-13" @default.
- W4312045304 title "Mitochondrial ATP Production is Required for Endothelial Cell Control of Vascular Tone" @default.
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