FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312056013> ?p ?o ?g. }

• W4312056013 endingPage "112042" @default.
• W4312056013 startingPage "112042" @default.
• W4312056013 abstract "Aging is one of the causes of male infertility, and abnormal global DNA methylation and imprinting defects have been characterized in testis during biological aging. One of the important emerging approaches aims to take advantage of the healing properties of young blood plasma to limit the progression of aging in various organs in the body. We aimed to show whether blood plasma transfer has an effect on DNA methylation and spermatogenetic cell development. In addition, we aimed to show whether the young plasma transfer to old mice has an effect on the rejuvenation of the old and whether the impaired DNA methylation and PCNA expression in old age can be restored.Groups were (i) young control, (ii) young plasma transfer to aged, (iii) aged control, (iv) aged plasma transfer to young. We utilized IHC and WB in protein level of Dnmts. For the global DNA methylation level, we used 5-methylcytosine staining. We also analyzed PCNA protein expressions in all groups by IHC.We found that transfusion of young plasma into the old animal restored DNA methylation and PCNA expression as it did in the young animal. Most importantly, we observed an increase in spermatogonia and spermatid counts in older animals after young blood plasma transfer.Our findings show that young plasma transfer can restore epigenetic disorders that occur with aging and solve infertility problems by increasing the sperm count that decreases. It needs to be supported by different studies, especially human studies." @default.
• W4312056013 created "2023-01-04" @default.
• W4312056013 creator A5002874792 @default.
• W4312056013 creator A5048924856 @default.
• W4312056013 creator A5055260212 @default.
• W4312056013 creator A5070939010 @default.
• W4312056013 creator A5077477942 @default.
• W4312056013 date "2023-02-01" @default.
• W4312056013 modified "2023-09-27" @default.
• W4312056013 title "Young plasma transfer recovers decreased sperm counts and restores epigenetics in aged testis" @default.
• W4312056013 cites W1412161755 @default.
• W4312056013 cites W1534737270 @default.
• W4312056013 cites W1588368936 @default.
• W4312056013 cites W1634826223 @default.
• W4312056013 cites W1978927200 @default.
• W4312056013 cites W1998273730 @default.
• W4312056013 cites W2005311687 @default.
• W4312056013 cites W2005838814 @default.
• W4312056013 cites W2022487205 @default.
• W4312056013 cites W2027889155 @default.
• W4312056013 cites W2050664489 @default.
• W4312056013 cites W2067102637 @default.
• W4312056013 cites W2073222687 @default.
• W4312056013 cites W2088341189 @default.
• W4312056013 cites W2090457301 @default.
• W4312056013 cites W2091929154 @default.
• W4312056013 cites W2124561450 @default.
• W4312056013 cites W2136270288 @default.
• W4312056013 cites W2139444346 @default.
• W4312056013 cites W2155678594 @default.
• W4312056013 cites W2157550195 @default.
• W4312056013 cites W2157886911 @default.
• W4312056013 cites W2159914115 @default.
• W4312056013 cites W2163670586 @default.
• W4312056013 cites W2262386854 @default.
• W4312056013 cites W2520842218 @default.
• W4312056013 cites W2554177165 @default.
• W4312056013 cites W2603284216 @default.
• W4312056013 cites W2606227689 @default.
• W4312056013 cites W2761766302 @default.
• W4312056013 cites W2774225631 @default.
• W4312056013 cites W2925291443 @default.
• W4312056013 cites W3139451809 @default.
• W4312056013 cites W4205960156 @default.
• W4312056013 cites W4289861021 @default.
• W4312056013 doi "https://doi.org/10.1016/j.exger.2022.112042" @default.
• W4312056013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36481396" @default.
• W4312056013 hasPublicationYear "2023" @default.
• W4312056013 type Work @default.
• W4312056013 citedByCount "2" @default.
• W4312056013 countsByYear W43120560132023 @default.
• W4312056013 crossrefType "journal-article" @default.
• W4312056013 hasAuthorship W4312056013A5002874792 @default.
• W4312056013 hasAuthorship W4312056013A5048924856 @default.
• W4312056013 hasAuthorship W4312056013A5055260212 @default.
• W4312056013 hasAuthorship W4312056013A5070939010 @default.
• W4312056013 hasAuthorship W4312056013A5077477942 @default.
• W4312056013 hasBestOaLocation W43120560131 @default.
• W4312056013 hasConcept C104317684 @default.
• W4312056013 hasConcept C123765429 @default.
• W4312056013 hasConcept C126322002 @default.
• W4312056013 hasConcept C134018914 @default.
• W4312056013 hasConcept C150194340 @default.
• W4312056013 hasConcept C16685009 @default.
• W4312056013 hasConcept C190727270 @default.
• W4312056013 hasConcept C203014093 @default.
• W4312056013 hasConcept C204232928 @default.
• W4312056013 hasConcept C2777394357 @default.
• W4312056013 hasConcept C2781087480 @default.
• W4312056013 hasConcept C33288867 @default.
• W4312056013 hasConcept C34688535 @default.
• W4312056013 hasConcept C41091548 @default.
• W4312056013 hasConcept C54355233 @default.
• W4312056013 hasConcept C552990157 @default.
• W4312056013 hasConcept C71924100 @default.
• W4312056013 hasConcept C86803240 @default.
• W4312056013 hasConceptScore W4312056013C104317684 @default.
• W4312056013 hasConceptScore W4312056013C123765429 @default.
• W4312056013 hasConceptScore W4312056013C126322002 @default.
• W4312056013 hasConceptScore W4312056013C134018914 @default.
• W4312056013 hasConceptScore W4312056013C150194340 @default.
• W4312056013 hasConceptScore W4312056013C16685009 @default.
• W4312056013 hasConceptScore W4312056013C190727270 @default.
• W4312056013 hasConceptScore W4312056013C203014093 @default.
• W4312056013 hasConceptScore W4312056013C204232928 @default.
• W4312056013 hasConceptScore W4312056013C2777394357 @default.
• W4312056013 hasConceptScore W4312056013C2781087480 @default.
• W4312056013 hasConceptScore W4312056013C33288867 @default.
• W4312056013 hasConceptScore W4312056013C34688535 @default.
• W4312056013 hasConceptScore W4312056013C41091548 @default.
• W4312056013 hasConceptScore W4312056013C54355233 @default.
• W4312056013 hasConceptScore W4312056013C552990157 @default.
• W4312056013 hasConceptScore W4312056013C71924100 @default.
• W4312056013 hasConceptScore W4312056013C86803240 @default.
• W4312056013 hasLocation W43120560131 @default.
• W4312056013 hasLocation W43120560132 @default.
• W4312056013 hasOpenAccess W4312056013 @default.
• W4312056013 hasPrimaryLocation W43120560131 @default.

• next