FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312057367> ?p ?o ?g. }

• W4312057367 endingPage "110" @default.
• W4312057367 startingPage "93" @default.
• W4312057367 abstract "Selenium is an essential trace element with both beneficial and detrimental effects on health depending on dose and chemical form. Currently, there is debate on recommendations for selenium supplementation as a public health measure to improve immune function and reduce infectious disease susceptibility.We performed a systematic review and meta-analysis of experimental studies assessing the effect of selenium supplementation on immunity-related outcomes in healthy people.We undertook a search of published and unpublished studies in literature databases such as PubMed/MEDLINE, Embase, and clinicaltrials.gov up to 17 October, 2022, and performed a meta-analysis comparing the effects on immunity-related outcomes between Se-supplemented versus control arms. Whenever possible we assessed the nonlinear relation using a dose-response approach.9 trials were included, 5 in North America, and 4 in Europe, with a duration between 8 and 48 weeks and supplementation of both inorganic and organic selenium forms. Selenium supplementation did not substantially affect immunoglobulin or white blood cell concentrations, and the dose-response meta-analysis indicated that an increase in plasma selenium concentrations above 100 μg/L did not further increase IgA levels nor T cells. An inverted U-shaped relation emerged for NK cell count, with a lower number of these cells both below and above 120 μg/L. The only beneficial effect of selenium supplementation was the increased activity for NK lysis, but the available data did not permit dose-response analysis. Cytokine levels were substantially unaffected by selenium supplementation.Although some of the data suggested beneficial effects of selenium supplementation on immune function, the overall picture appears to be inconsistent and heterogeneous due to differences in trial duration and interventions, plus evidence of null and even detrimental effects. Overall, the evidence that we extracted from the literature in this systematic review does not support the need to supplement selenium beyond the recommended dietary intake to obtain beneficial effects on immune function. This trial was registered at PROSPERO (CRD42022312280)." @default.
• W4312057367 created "2023-01-04" @default.
• W4312057367 creator A5019308808 @default.
• W4312057367 creator A5024697101 @default.
• W4312057367 creator A5077899672 @default.
• W4312057367 date "2023-01-01" @default.
• W4312057367 modified "2023-09-30" @default.
• W4312057367 title "Selenium and immune function: a systematic review and meta-analysis of experimental human studies" @default.
• W4312057367 cites W1894992122 @default.
• W4312057367 cites W1966704784 @default.
• W4312057367 cites W1968966900 @default.
• W4312057367 cites W1976004420 @default.
• W4312057367 cites W1981522941 @default.
• W4312057367 cites W1986378808 @default.
• W4312057367 cites W1989454363 @default.
• W4312057367 cites W2019032733 @default.
• W4312057367 cites W2026393494 @default.
• W4312057367 cites W2029673825 @default.
• W4312057367 cites W2036070813 @default.
• W4312057367 cites W2047765480 @default.
• W4312057367 cites W2053528495 @default.
• W4312057367 cites W2074769261 @default.
• W4312057367 cites W2089975801 @default.
• W4312057367 cites W2092340004 @default.
• W4312057367 cites W2094426390 @default.
• W4312057367 cites W2101102585 @default.
• W4312057367 cites W2125076467 @default.
• W4312057367 cites W2132616354 @default.
• W4312057367 cites W2140871534 @default.
• W4312057367 cites W2147056787 @default.
• W4312057367 cites W2165602041 @default.
• W4312057367 cites W2168863734 @default.
• W4312057367 cites W2221588476 @default.
• W4312057367 cites W2293040502 @default.
• W4312057367 cites W2408017125 @default.
• W4312057367 cites W2553675133 @default.
• W4312057367 cites W2800621949 @default.
• W4312057367 cites W2882390955 @default.
• W4312057367 cites W2889290358 @default.
• W4312057367 cites W2895076745 @default.
• W4312057367 cites W2904376056 @default.
• W4312057367 cites W2970684805 @default.
• W4312057367 cites W2978195983 @default.
• W4312057367 cites W3036875043 @default.
• W4312057367 cites W3100949256 @default.
• W4312057367 cites W3129476002 @default.
• W4312057367 cites W3140931767 @default.
• W4312057367 cites W3141256924 @default.
• W4312057367 cites W3153651669 @default.
• W4312057367 cites W3156911490 @default.
• W4312057367 cites W3203933803 @default.
• W4312057367 cites W4210357484 @default.
• W4312057367 cites W4210509071 @default.
• W4312057367 cites W4220902720 @default.
• W4312057367 cites W4224442122 @default.
• W4312057367 cites W4226098998 @default.
• W4312057367 cites W910015380 @default.
• W4312057367 doi "https://doi.org/10.1016/j.ajcnut.2022.11.007" @default.
• W4312057367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36789948" @default.
• W4312057367 hasPublicationYear "2023" @default.
• W4312057367 type Work @default.
• W4312057367 citedByCount "5" @default.
• W4312057367 countsByYear W43120573672023 @default.
• W4312057367 crossrefType "journal-article" @default.
• W4312057367 hasAuthorship W4312057367A5019308808 @default.
• W4312057367 hasAuthorship W4312057367A5024697101 @default.
• W4312057367 hasAuthorship W4312057367A5077899672 @default.
• W4312057367 hasConcept C126322002 @default.
• W4312057367 hasConcept C178790620 @default.
• W4312057367 hasConcept C185592680 @default.
• W4312057367 hasConcept C203014093 @default.
• W4312057367 hasConcept C2779341262 @default.
• W4312057367 hasConcept C42407357 @default.
• W4312057367 hasConcept C553756173 @default.
• W4312057367 hasConcept C71924100 @default.
• W4312057367 hasConcept C8891405 @default.
• W4312057367 hasConcept C95190672 @default.
• W4312057367 hasConceptScore W4312057367C126322002 @default.
• W4312057367 hasConceptScore W4312057367C178790620 @default.
• W4312057367 hasConceptScore W4312057367C185592680 @default.
• W4312057367 hasConceptScore W4312057367C203014093 @default.
• W4312057367 hasConceptScore W4312057367C2779341262 @default.
• W4312057367 hasConceptScore W4312057367C42407357 @default.
• W4312057367 hasConceptScore W4312057367C553756173 @default.
• W4312057367 hasConceptScore W4312057367C71924100 @default.
• W4312057367 hasConceptScore W4312057367C8891405 @default.
• W4312057367 hasConceptScore W4312057367C95190672 @default.
• W4312057367 hasIssue "1" @default.
• W4312057367 hasLocation W43120573671 @default.
• W4312057367 hasLocation W43120573672 @default.
• W4312057367 hasOpenAccess W4312057367 @default.
• W4312057367 hasPrimaryLocation W43120573671 @default.
• W4312057367 hasRelatedWork W2057948995 @default.
• W4312057367 hasRelatedWork W2223869382 @default.
• W4312057367 hasRelatedWork W2369807096 @default.
• W4312057367 hasRelatedWork W2389343636 @default.
• W4312057367 hasRelatedWork W2993057445 @default.
• W4312057367 hasRelatedWork W3017822181 @default.

• next