FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312059105> ?p ?o ?g. }

• W4312059105 endingPage "324184" @default.
• W4312059105 startingPage "fetalneonatal" @default.
• W4312059105 abstract "Objective To perform a network meta-analysis of randomised controlled trials of different surfactant treatment strategies for respiratory distress syndrome (RDS) to assess if a certain fraction of inspired oxygen (FiO 2 ) is optimal for selective surfactant therapy. Design Systematic review and network meta-analysis using Bayesian analysis of randomised trials of prophylactic versus selective surfactant for RDS. Setting Cochrane Central Register of Controlled Trials, MEDLINE, Embase and Science Citation Index Expanded. Patients Randomised trials including infants under 32 weeks of gestational age. Interventions Intratracheal surfactant, irrespective of type or dose. Main outcome measures Our primary outcome was neonatal mortality, compared between groups treated with selective surfactant therapy at different thresholds of FiO 2 . Secondary outcomes included respiratory morbidity and major complications of prematurity. Results Of 4643 identified references, 14 studies involving 5298 participants were included. We found no statistically significant differences between 30%, 40% and 50% FiO 2 thresholds. A sensitivity analysis of infants treated in the era of high antenatal steroid use and nasal continuous positive airway pressure as initial mode of respiratory support showed no difference in mortality, RDS or intraventricular haemorrhage alone but suggested an increase in the combined outcome of major morbidities in the 60% threshold. Conclusion Our results do not show a clear benefit of surfactant treatment at any threshold of FiO 2 . The 60% threshold was suggestive of increased morbidity. There was no advantage seen with prophylactic treatment. Randomised trials of different thresholds for surfactant delivery are urgently needed to guide clinicians and provide robust evidence. PROSPERO registration number CRD42020166620." @default.
• W4312059105 created "2023-01-04" @default.
• W4312059105 creator A5031229224 @default.
• W4312059105 creator A5031833906 @default.
• W4312059105 creator A5048935246 @default.
• W4312059105 creator A5075867834 @default.
• W4312059105 date "2022-12-09" @default.
• W4312059105 modified "2023-09-27" @default.
• W4312059105 title "Thresholds for surfactant use in preterm neonates: a network meta-analysis" @default.
• W4312059105 cites W1518678424 @default.
• W4312059105 cites W1604424333 @default.
• W4312059105 cites W1969069646 @default.
• W4312059105 cites W1998193241 @default.
• W4312059105 cites W2000480240 @default.
• W4312059105 cites W2004081874 @default.
• W4312059105 cites W2010699829 @default.
• W4312059105 cites W2022916613 @default.
• W4312059105 cites W2028758728 @default.
• W4312059105 cites W2034818022 @default.
• W4312059105 cites W2046224781 @default.
• W4312059105 cites W2053931185 @default.
• W4312059105 cites W2058340730 @default.
• W4312059105 cites W2058898229 @default.
• W4312059105 cites W2067292954 @default.
• W4312059105 cites W2075132426 @default.
• W4312059105 cites W2077653789 @default.
• W4312059105 cites W2084976705 @default.
• W4312059105 cites W2086135383 @default.
• W4312059105 cites W2089288497 @default.
• W4312059105 cites W2091808438 @default.
• W4312059105 cites W2097089311 @default.
• W4312059105 cites W2150529573 @default.
• W4312059105 cites W2152759613 @default.
• W4312059105 cites W2153001272 @default.
• W4312059105 cites W2169645416 @default.
• W4312059105 cites W2210128369 @default.
• W4312059105 cites W2215805726 @default.
• W4312059105 cites W2216607261 @default.
• W4312059105 cites W2323149989 @default.
• W4312059105 cites W2343973832 @default.
• W4312059105 cites W2413796441 @default.
• W4312059105 cites W2475066196 @default.
• W4312059105 cites W2594273274 @default.
• W4312059105 cites W2804159672 @default.
• W4312059105 cites W2936595371 @default.
• W4312059105 cites W2970684805 @default.
• W4312059105 cites W301633323 @default.
• W4312059105 cites W3023778523 @default.
• W4312059105 cites W3126922579 @default.
• W4312059105 cites W3148465273 @default.
• W4312059105 cites W4210288536 @default.
• W4312059105 cites W4376848370 @default.
• W4312059105 doi "https://doi.org/10.1136/archdischild-2022-324184" @default.
• W4312059105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36600484" @default.
• W4312059105 hasPublicationYear "2022" @default.
• W4312059105 type Work @default.
• W4312059105 citedByCount "1" @default.
• W4312059105 countsByYear W43120591052023 @default.
• W4312059105 crossrefType "journal-article" @default.
• W4312059105 hasAuthorship W4312059105A5031229224 @default.
• W4312059105 hasAuthorship W4312059105A5031833906 @default.
• W4312059105 hasAuthorship W4312059105A5048935246 @default.
• W4312059105 hasAuthorship W4312059105A5075867834 @default.
• W4312059105 hasBestOaLocation W43120591052 @default.
• W4312059105 hasConcept C105922876 @default.
• W4312059105 hasConcept C126322002 @default.
• W4312059105 hasConcept C141983124 @default.
• W4312059105 hasConcept C168563851 @default.
• W4312059105 hasConcept C177713679 @default.
• W4312059105 hasConcept C187212893 @default.
• W4312059105 hasConcept C2776006263 @default.
• W4312059105 hasConcept C2776478404 @default.
• W4312059105 hasConcept C2776596748 @default.
• W4312059105 hasConcept C2776953283 @default.
• W4312059105 hasConcept C2778376644 @default.
• W4312059105 hasConcept C2778721537 @default.
• W4312059105 hasConcept C2779234561 @default.
• W4312059105 hasConcept C2779252433 @default.
• W4312059105 hasConcept C2779547634 @default.
• W4312059105 hasConcept C42219234 @default.
• W4312059105 hasConcept C54355233 @default.
• W4312059105 hasConcept C71924100 @default.
• W4312059105 hasConcept C86803240 @default.
• W4312059105 hasConcept C95190672 @default.
• W4312059105 hasConceptScore W4312059105C105922876 @default.
• W4312059105 hasConceptScore W4312059105C126322002 @default.
• W4312059105 hasConceptScore W4312059105C141983124 @default.
• W4312059105 hasConceptScore W4312059105C168563851 @default.
• W4312059105 hasConceptScore W4312059105C177713679 @default.
• W4312059105 hasConceptScore W4312059105C187212893 @default.
• W4312059105 hasConceptScore W4312059105C2776006263 @default.
• W4312059105 hasConceptScore W4312059105C2776478404 @default.
• W4312059105 hasConceptScore W4312059105C2776596748 @default.
• W4312059105 hasConceptScore W4312059105C2776953283 @default.
• W4312059105 hasConceptScore W4312059105C2778376644 @default.
• W4312059105 hasConceptScore W4312059105C2778721537 @default.
• W4312059105 hasConceptScore W4312059105C2779234561 @default.
• W4312059105 hasConceptScore W4312059105C2779252433 @default.

• next