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- W4312066260 abstract "To explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI. C57BL/6 mice and EL-4 cells were used in this research. The ALI model was established by CLP. The level of inflammatory cytokines in the lung and blood, the severity of lung injury, the expression of Foxp3, and the proportion of Tregs were detected before and after dexmedetomidine treatment. The expression of the AMPK/SIRT1 after dexmedetomidine treatment was detected in vivo and in vitro. After blocking the AMPK/SIRT1 pathway or depleting Tregs in vivo, the level of the inflammatory response, tissue injury, and Tregs differentiation were detected again to clarify the effect of dexmedetomidine. Dexmedetomidine significantly reduced systemic inflammation and lung injury in CLP mice. Dexmedetomidine enhanced the Foxp3 expression in the lungs and the frequency of Tregs in the spleen. Dexmedetomidine up-regulated the protein expression of p-AMPK and SIRT1 in lungs and EL-4 cells and facilitated the differentiation of naïve CD4+ T cells into Tregs in vitro. Meanwhile, DEX also increased the expression of Helios in Treg cells. DEX could improve ARDS/ALI by facilitating the differentiation of Tregs from naïve CD4+ T cells via activating the AMPK/SIRT1 pathway." @default.
- W4312066260 created "2023-01-04" @default.
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- W4312066260 date "2022-12-19" @default.
- W4312066260 modified "2023-10-16" @default.
- W4312066260 title "Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway" @default.
- W4312066260 cites W1492966940 @default.
- W4312066260 cites W1803784511 @default.
- W4312066260 cites W1965393811 @default.
- W4312066260 cites W1979504051 @default.
- W4312066260 cites W1999906527 @default.
- W4312066260 cites W2008271242 @default.
- W4312066260 cites W2022267544 @default.
- W4312066260 cites W2030284768 @default.
- W4312066260 cites W2067147062 @default.
- W4312066260 cites W2086194617 @default.
- W4312066260 cites W2111178592 @default.
- W4312066260 cites W2131172391 @default.
- W4312066260 cites W2146226755 @default.
- W4312066260 cites W2189204464 @default.
- W4312066260 cites W2317488575 @default.
- W4312066260 cites W2514209073 @default.
- W4312066260 cites W2576234460 @default.
- W4312066260 cites W2580993081 @default.
- W4312066260 cites W2588946552 @default.
- W4312066260 cites W2620241325 @default.
- W4312066260 cites W2763871199 @default.
- W4312066260 cites W2790030881 @default.
- W4312066260 cites W2792870066 @default.
- W4312066260 cites W2793513555 @default.
- W4312066260 cites W2801326558 @default.
- W4312066260 cites W2803570246 @default.
- W4312066260 cites W2823571324 @default.
- W4312066260 cites W2886979294 @default.
- W4312066260 cites W2902058990 @default.
- W4312066260 cites W2909652098 @default.
- W4312066260 cites W2912580500 @default.
- W4312066260 cites W2922398723 @default.
- W4312066260 cites W2927692598 @default.
- W4312066260 cites W2944380916 @default.
- W4312066260 cites W2944938822 @default.
- W4312066260 cites W2959995664 @default.
- W4312066260 cites W2965819160 @default.
- W4312066260 cites W2972937353 @default.
- W4312066260 cites W2975736787 @default.
- W4312066260 cites W2976863088 @default.
- W4312066260 cites W2981183570 @default.
- W4312066260 cites W2999902161 @default.
- W4312066260 cites W2999914372 @default.
- W4312066260 cites W3003763447 @default.
- W4312066260 cites W3006891752 @default.
- W4312066260 cites W3007923702 @default.
- W4312066260 cites W3010356478 @default.
- W4312066260 cites W3010813076 @default.
- W4312066260 cites W3011754665 @default.
- W4312066260 cites W3012186724 @default.
- W4312066260 cites W3014985924 @default.
- W4312066260 cites W3015607499 @default.
- W4312066260 cites W3020955718 @default.
- W4312066260 cites W3021244522 @default.
- W4312066260 cites W3025324697 @default.
- W4312066260 cites W3035085974 @default.
- W4312066260 cites W3038745441 @default.
- W4312066260 cites W3042587964 @default.
- W4312066260 cites W3044563152 @default.
- W4312066260 cites W3067949021 @default.
- W4312066260 cites W3074132043 @default.
- W4312066260 cites W3093050672 @default.
- W4312066260 cites W3099389154 @default.
- W4312066260 cites W3101696034 @default.
- W4312066260 cites W3112902030 @default.
- W4312066260 cites W3113796356 @default.
- W4312066260 cites W3118627335 @default.
- W4312066260 cites W3126120698 @default.
- W4312066260 cites W3137346150 @default.
- W4312066260 cites W3138865983 @default.
- W4312066260 cites W3165390912 @default.
- W4312066260 cites W3173452679 @default.
- W4312066260 cites W3175283097 @default.
- W4312066260 cites W3188424524 @default.
- W4312066260 cites W4200177378 @default.
- W4312066260 cites W4205735962 @default.
- W4312066260 cites W4210371242 @default.
- W4312066260 cites W4211250103 @default.
- W4312066260 cites W4237939525 @default.
- W4312066260 doi "https://doi.org/10.1007/s10787-022-01117-5" @default.
- W4312066260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36534240" @default.
- W4312066260 hasPublicationYear "2022" @default.
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