Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312067461> ?p ?o ?g. }
- W4312067461 abstract "There is debate in the field of oncolytic virus (OV) therapy, whether a single viral dose, or multiple administrations, is better for tumor control. Using intravital microscopy, we describe the fate of vesicular stomatitis virus (VSV) delivered systemically as a first or a second dose. Following primary administration, VSV binds to the endothelium, initiates tumor infection and activates a proinflammatory response. This initial OV dose induces neutrophil migration into the tumor and limits viral replication. OV administered as a second dose fails to infect the tumor and is captured by intravascular monocytes. Despite a lack of direct infection, this second viral dose, in a monocyte-dependent fashion, enhances and sustains infection by the first viral dose, promotes CD8 T cell recruitment, delays tumor growth and improves survival in multi-dosing OV therapy. Thus, repeated VSV dosing engages monocytes to post-condition the tumor microenvironment for improved infection and anticancer T cell responses. Understanding the complex interactions between the subsequent viral doses is crucial for improving the efficiency of OV therapy and virus-based vaccines." @default.
- W4312067461 created "2023-01-04" @default.
- W4312067461 creator A5001275410 @default.
- W4312067461 creator A5004341297 @default.
- W4312067461 creator A5006500798 @default.
- W4312067461 creator A5014123251 @default.
- W4312067461 creator A5015768354 @default.
- W4312067461 creator A5015858759 @default.
- W4312067461 creator A5020100438 @default.
- W4312067461 creator A5023806072 @default.
- W4312067461 creator A5051972386 @default.
- W4312067461 creator A5056954970 @default.
- W4312067461 creator A5076965404 @default.
- W4312067461 creator A5078012011 @default.
- W4312067461 creator A5078638626 @default.
- W4312067461 creator A5084276980 @default.
- W4312067461 creator A5086018071 @default.
- W4312067461 date "2022-12-19" @default.
- W4312067461 modified "2023-10-14" @default.
- W4312067461 title "Repeated dosing improves oncolytic rhabdovirus therapy in mice via interactions with intravascular monocytes" @default.
- W4312067461 cites W1482790870 @default.
- W4312067461 cites W1910296004 @default.
- W4312067461 cites W1965916060 @default.
- W4312067461 cites W1986462840 @default.
- W4312067461 cites W1993412993 @default.
- W4312067461 cites W1998186561 @default.
- W4312067461 cites W1999515277 @default.
- W4312067461 cites W2008553086 @default.
- W4312067461 cites W2008620560 @default.
- W4312067461 cites W2010328268 @default.
- W4312067461 cites W2010942909 @default.
- W4312067461 cites W2016032323 @default.
- W4312067461 cites W2016921623 @default.
- W4312067461 cites W2018693726 @default.
- W4312067461 cites W2019206924 @default.
- W4312067461 cites W2024040080 @default.
- W4312067461 cites W2033344463 @default.
- W4312067461 cites W2034355730 @default.
- W4312067461 cites W2037123168 @default.
- W4312067461 cites W2037800562 @default.
- W4312067461 cites W2049092411 @default.
- W4312067461 cites W2055918136 @default.
- W4312067461 cites W2057672138 @default.
- W4312067461 cites W2059672311 @default.
- W4312067461 cites W2074725872 @default.
- W4312067461 cites W2079990421 @default.
- W4312067461 cites W2088594694 @default.
- W4312067461 cites W2096574915 @default.
- W4312067461 cites W2105848229 @default.
- W4312067461 cites W2106627189 @default.
- W4312067461 cites W2110410873 @default.
- W4312067461 cites W2111253543 @default.
- W4312067461 cites W2130703653 @default.
- W4312067461 cites W2131188831 @default.
- W4312067461 cites W2138780833 @default.
- W4312067461 cites W2150701651 @default.
- W4312067461 cites W2151826099 @default.
- W4312067461 cites W2165386071 @default.
- W4312067461 cites W2508611939 @default.
- W4312067461 cites W2595403257 @default.
- W4312067461 cites W2748739447 @default.
- W4312067461 cites W2749609329 @default.
- W4312067461 cites W2760883434 @default.
- W4312067461 cites W2770961735 @default.
- W4312067461 cites W2778445562 @default.
- W4312067461 cites W2784225913 @default.
- W4312067461 cites W2800862488 @default.
- W4312067461 cites W2803616070 @default.
- W4312067461 cites W2882978751 @default.
- W4312067461 cites W2884278530 @default.
- W4312067461 cites W2891038428 @default.
- W4312067461 cites W2892787129 @default.
- W4312067461 cites W2947367516 @default.
- W4312067461 cites W2971367932 @default.
- W4312067461 cites W2984628891 @default.
- W4312067461 cites W3042833857 @default.
- W4312067461 cites W3045648994 @default.
- W4312067461 cites W3111426898 @default.
- W4312067461 cites W3153508314 @default.
- W4312067461 cites W3155652922 @default.
- W4312067461 cites W84968995 @default.
- W4312067461 doi "https://doi.org/10.1038/s42003-022-04254-3" @default.
- W4312067461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36536097" @default.
- W4312067461 hasPublicationYear "2022" @default.
- W4312067461 type Work @default.
- W4312067461 citedByCount "0" @default.
- W4312067461 crossrefType "journal-article" @default.
- W4312067461 hasAuthorship W4312067461A5001275410 @default.
- W4312067461 hasAuthorship W4312067461A5004341297 @default.
- W4312067461 hasAuthorship W4312067461A5006500798 @default.
- W4312067461 hasAuthorship W4312067461A5014123251 @default.
- W4312067461 hasAuthorship W4312067461A5015768354 @default.
- W4312067461 hasAuthorship W4312067461A5015858759 @default.
- W4312067461 hasAuthorship W4312067461A5020100438 @default.
- W4312067461 hasAuthorship W4312067461A5023806072 @default.
- W4312067461 hasAuthorship W4312067461A5051972386 @default.
- W4312067461 hasAuthorship W4312067461A5056954970 @default.
- W4312067461 hasAuthorship W4312067461A5076965404 @default.
- W4312067461 hasAuthorship W4312067461A5078012011 @default.
- W4312067461 hasAuthorship W4312067461A5078638626 @default.