FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312069905> ?p ?o ?g. }

• W4312069905 endingPage "12" @default.
• W4312069905 startingPage "12" @default.
• W4312069905 abstract "Reporter genes inserted via P-element integration into different locations of the Drosophila melanogaster genome have been routinely used to monitor the functional state of chromatin domains. It is commonly thought that P-element-derived reporter genes are subjected to position effect variegation (PEV) when transposed into constitutive heterochromatin because they acquire heterochromatin-like epigenetic modifications that promote silencing. However, sequencing and annotation of the D. melanogaster genome have shown that constitutive heterochromatin is a genetically and molecularly heterogeneous compartment. In fact, in addition to repetitive DNAs, it harbors hundreds of functional genes, together accounting for a significant fraction of its entire genomic territory. Notably, most of these genes are actively transcribed in different developmental stages and tissues, irrespective of their location in heterochromatin. An open question in the genetic and molecular studies on PEV in D. melanogaster is whether functional heterochromatin domains, i.e., heterochromatin harboring active genes, are able to silence reporter genes therein transposed or, on the contrary, can drive their expression. In this work, we provide experimental evidence showing that strong silencing of the Pw+ reporters is induced even when they are integrated within or near actively transcribed loci in the pericentric regions of chromosome 2. Interestingly, some Pw+ reporters were found insensitive to the action of a known PEV suppressor. Two of them are inserted within Yeti, a gene expressed in the deep heterochromatin of chromosome 2 which carries active chromatin marks. The difference sensitivity to suppressors-exhibited Pw+ reporters supports the view that different epigenetic regulators or mechanisms control different regions of heterochromatin. Together, our results suggest that there may be more complexity regarding the molecular mechanisms underlying PEV." @default.
• W4312069905 created "2023-01-04" @default.
• W4312069905 creator A5041109715 @default.
• W4312069905 creator A5042871266 @default.
• W4312069905 creator A5067215769 @default.
• W4312069905 creator A5075702501 @default.
• W4312069905 creator A5084586268 @default.
• W4312069905 date "2022-12-21" @default.
• W4312069905 modified "2023-10-18" @default.
• W4312069905 title "Epigenetic Silencing of P-Element Reporter Genes Induced by Transcriptionally Active Domains of Constitutive Heterochromatin in Drosophila melanogaster" @default.
• W4312069905 cites W132297753 @default.
• W4312069905 cites W1484634686 @default.
• W4312069905 cites W1509466986 @default.
• W4312069905 cites W1603793127 @default.
• W4312069905 cites W171105309 @default.
• W4312069905 cites W1778889988 @default.
• W4312069905 cites W1820076796 @default.
• W4312069905 cites W1832452463 @default.
• W4312069905 cites W1860733958 @default.
• W4312069905 cites W1875840637 @default.
• W4312069905 cites W1887914193 @default.
• W4312069905 cites W1910936647 @default.
• W4312069905 cites W1914815907 @default.
• W4312069905 cites W1928111150 @default.
• W4312069905 cites W1973279225 @default.
• W4312069905 cites W1989322815 @default.
• W4312069905 cites W1994528729 @default.
• W4312069905 cites W1995576030 @default.
• W4312069905 cites W1999284470 @default.
• W4312069905 cites W1999955752 @default.
• W4312069905 cites W2018420071 @default.
• W4312069905 cites W2018442148 @default.
• W4312069905 cites W2019708066 @default.
• W4312069905 cites W2022097553 @default.
• W4312069905 cites W2023919862 @default.
• W4312069905 cites W2031406887 @default.
• W4312069905 cites W2033828311 @default.
• W4312069905 cites W2034108485 @default.
• W4312069905 cites W2034521715 @default.
• W4312069905 cites W2036690337 @default.
• W4312069905 cites W2037589637 @default.
• W4312069905 cites W2039278637 @default.
• W4312069905 cites W2041085105 @default.
• W4312069905 cites W2041731107 @default.
• W4312069905 cites W2044251005 @default.
• W4312069905 cites W2055734355 @default.
• W4312069905 cites W2073915279 @default.
• W4312069905 cites W2076092946 @default.
• W4312069905 cites W2076960530 @default.
• W4312069905 cites W2085107624 @default.
• W4312069905 cites W2086734460 @default.
• W4312069905 cites W2087558654 @default.
• W4312069905 cites W2096474417 @default.
• W4312069905 cites W2100151569 @default.
• W4312069905 cites W2100270425 @default.
• W4312069905 cites W2102385769 @default.
• W4312069905 cites W2108166262 @default.
• W4312069905 cites W2108336999 @default.
• W4312069905 cites W2110618077 @default.
• W4312069905 cites W2113019165 @default.
• W4312069905 cites W2117616460 @default.
• W4312069905 cites W2117734505 @default.
• W4312069905 cites W2122338068 @default.
• W4312069905 cites W2122774081 @default.
• W4312069905 cites W2125593645 @default.
• W4312069905 cites W2129301466 @default.
• W4312069905 cites W2136032865 @default.
• W4312069905 cites W2136269640 @default.
• W4312069905 cites W2137196963 @default.
• W4312069905 cites W2140461124 @default.
• W4312069905 cites W2140516843 @default.
• W4312069905 cites W2143264878 @default.
• W4312069905 cites W2146865647 @default.
• W4312069905 cites W2149325039 @default.
• W4312069905 cites W2160838716 @default.
• W4312069905 cites W2164339920 @default.
• W4312069905 cites W2167334533 @default.
• W4312069905 cites W2168585378 @default.
• W4312069905 cites W2170671616 @default.
• W4312069905 cites W2345733055 @default.
• W4312069905 cites W2593095770 @default.
• W4312069905 cites W2953220629 @default.
• W4312069905 cites W2958626972 @default.
• W4312069905 cites W2964803743 @default.
• W4312069905 cites W3087081867 @default.
• W4312069905 cites W3091814484 @default.
• W4312069905 cites W3159647569 @default.
• W4312069905 cites W4205542671 @default.
• W4312069905 cites W4213320741 @default.
• W4312069905 cites W4220919680 @default.
• W4312069905 cites W4235074948 @default.
• W4312069905 cites W4297973479 @default.
• W4312069905 doi "https://doi.org/10.3390/genes14010012" @default.
• W4312069905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36672753" @default.
• W4312069905 hasPublicationYear "2022" @default.
• W4312069905 type Work @default.
• W4312069905 citedByCount "3" @default.
• W4312069905 countsByYear W43120699052023 @default.

• next