Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312076945> ?p ?o ?g. }
- W4312076945 endingPage "2201232" @default.
- W4312076945 startingPage "2201232" @default.
- W4312076945 abstract "Risk stratification and assessment of disease progression in patients with pulmonary arterial hypertension (PAH) are challenged by the lack of accurate disease-specific and prognostic biomarkers. To date, brain natriuretic peptide (BNP) and/or its N-terminal fragment (NT-proBNP) are the only markers for right ventricular dysfunction used in clinical practice, in association with echocardiographic and invasive haemodynamic variables to predict outcome in patients with PAH.This study was designed to identify an easily measurable biomarker panel in the serum of 80 well-phenotyped PAH patients with idiopathic, heritable or drug-induced PAH at baseline and at first follow-up. The prognostic value of identified cytokines of interest was secondly analysed in an external validation cohort of 125 PAH patients.Among the 20 biomarkers studied with the multiplex Ella platform, we identified a three-biomarker panel composed of β-NGF, CXCL9 and TRAIL that were independently associated with prognosis both at the time of PAH diagnosis and at the first follow-up after initiation of PAH therapy. β-NGF and CXCL9 were predictors of death or transplantation, whereas high levels of TRAIL were associated with a better prognosis. Furthermore, the prognostic value of the three cytokines was more powerful for predicting survival than usual non-invasive variables (New York Heart Association Functional Class, 6-min walk distance and BNP/NT-proBNP). The results were validated in a fully independent external validation cohort.The monitoring of β-NGF, CXCL9 and TRAIL levels in serum should be considered in the management and treatment of patients with PAH to objectively guide therapeutic options." @default.
- W4312076945 created "2023-01-04" @default.
- W4312076945 creator A5009143464 @default.
- W4312076945 creator A5032985944 @default.
- W4312076945 creator A5034307417 @default.
- W4312076945 creator A5036242687 @default.
- W4312076945 creator A5036327913 @default.
- W4312076945 creator A5038824744 @default.
- W4312076945 creator A5042206192 @default.
- W4312076945 creator A5044263590 @default.
- W4312076945 creator A5059392358 @default.
- W4312076945 creator A5067747780 @default.
- W4312076945 creator A5068191376 @default.
- W4312076945 creator A5071103679 @default.
- W4312076945 creator A5077085879 @default.
- W4312076945 creator A5078054842 @default.
- W4312076945 creator A5082059107 @default.
- W4312076945 creator A5085643508 @default.
- W4312076945 creator A5090333661 @default.
- W4312076945 date "2022-12-22" @default.
- W4312076945 modified "2023-10-17" @default.
- W4312076945 title "Cytokines as prognostic biomarkers in pulmonary arterial hypertension" @default.
- W4312076945 cites W1825951622 @default.
- W4312076945 cites W1866413456 @default.
- W4312076945 cites W1912311988 @default.
- W4312076945 cites W1987693654 @default.
- W4312076945 cites W2026469629 @default.
- W4312076945 cites W2036142929 @default.
- W4312076945 cites W2041797267 @default.
- W4312076945 cites W2049604140 @default.
- W4312076945 cites W2111436983 @default.
- W4312076945 cites W2114374604 @default.
- W4312076945 cites W2116090753 @default.
- W4312076945 cites W2117339256 @default.
- W4312076945 cites W2132001965 @default.
- W4312076945 cites W2150534880 @default.
- W4312076945 cites W2150562642 @default.
- W4312076945 cites W2157601642 @default.
- W4312076945 cites W2161370807 @default.
- W4312076945 cites W2170102052 @default.
- W4312076945 cites W2548646658 @default.
- W4312076945 cites W2551406180 @default.
- W4312076945 cites W2606714207 @default.
- W4312076945 cites W2616253522 @default.
- W4312076945 cites W2626672968 @default.
- W4312076945 cites W2744074505 @default.
- W4312076945 cites W2766573731 @default.
- W4312076945 cites W2884446054 @default.
- W4312076945 cites W2887333106 @default.
- W4312076945 cites W2889581918 @default.
- W4312076945 cites W2904180601 @default.
- W4312076945 cites W2904385559 @default.
- W4312076945 cites W2905205873 @default.
- W4312076945 cites W2905582258 @default.
- W4312076945 cites W2910584107 @default.
- W4312076945 cites W2911671206 @default.
- W4312076945 cites W2920887517 @default.
- W4312076945 cites W2989461024 @default.
- W4312076945 cites W3022420910 @default.
- W4312076945 cites W3116615412 @default.
- W4312076945 cites W3119211282 @default.
- W4312076945 cites W3157936945 @default.
- W4312076945 cites W3174814045 @default.
- W4312076945 cites W4225377319 @default.
- W4312076945 cites W88989445 @default.
- W4312076945 doi "https://doi.org/10.1183/13993003.01232-2022" @default.
- W4312076945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36549710" @default.
- W4312076945 hasPublicationYear "2022" @default.
- W4312076945 type Work @default.
- W4312076945 citedByCount "6" @default.
- W4312076945 countsByYear W43120769452023 @default.
- W4312076945 crossrefType "journal-article" @default.
- W4312076945 hasAuthorship W4312076945A5009143464 @default.
- W4312076945 hasAuthorship W4312076945A5032985944 @default.
- W4312076945 hasAuthorship W4312076945A5034307417 @default.
- W4312076945 hasAuthorship W4312076945A5036242687 @default.
- W4312076945 hasAuthorship W4312076945A5036327913 @default.
- W4312076945 hasAuthorship W4312076945A5038824744 @default.
- W4312076945 hasAuthorship W4312076945A5042206192 @default.
- W4312076945 hasAuthorship W4312076945A5044263590 @default.
- W4312076945 hasAuthorship W4312076945A5059392358 @default.
- W4312076945 hasAuthorship W4312076945A5067747780 @default.
- W4312076945 hasAuthorship W4312076945A5068191376 @default.
- W4312076945 hasAuthorship W4312076945A5071103679 @default.
- W4312076945 hasAuthorship W4312076945A5077085879 @default.
- W4312076945 hasAuthorship W4312076945A5078054842 @default.
- W4312076945 hasAuthorship W4312076945A5082059107 @default.
- W4312076945 hasAuthorship W4312076945A5085643508 @default.
- W4312076945 hasAuthorship W4312076945A5090333661 @default.
- W4312076945 hasBestOaLocation W43120769452 @default.
- W4312076945 hasConcept C126322002 @default.
- W4312076945 hasConcept C143998085 @default.
- W4312076945 hasConcept C164705383 @default.
- W4312076945 hasConcept C178853913 @default.
- W4312076945 hasConcept C185592680 @default.
- W4312076945 hasConcept C2775846464 @default.
- W4312076945 hasConcept C2775915353 @default.
- W4312076945 hasConcept C2778198053 @default.