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• W4312077883 abstract "Abstract We conducted a multi-center study to analyze factors predicting survival among patients with TP53- mutated (m) AML receiving allogeneic hematopoietic stem cell transplant (allo-HSCT) in the recent era. Among 370 patients, 68 (18%) patients were bridge to allo-HSCT. The median age of the patients was 63 years (range, 33–75), 82% of patients had complex cytogenetics and 66% of patients had multi-hit TP53 m. Forty three percent received myeloablative conditioning (MAC) and 57% received reduced intensity conditioning (RIC). The incidence of acute graft versus host disease (GVHD) was 37% and chronic GVHD was 44%. The median event-free survival (EFS) from the time of allo-HSCT was 12.4 months (95% CI: 6.24–18.55) and median overall survival (OS) was 24.5 months (95% CI: 21.80-27.25). In multivariate analysis utilizing variables that showed significance in univariate analysis, complete remission at day 100 post allo-HSCT retained significance for EFS (HR: 0.24, 95% CI: 0.10–0.57, p = 0.001) and OS (HR: 0.22, 95% CI: 0.10–0.50, p = < 0.001). Similarly, occurrence of chronic GVHD retained significance for EFS (HR: 0.21, 95% CI: 0.09–0.46, p = < 0.001) and OS (HR: 0.34, 95% CI: 0.15–0.75, p = 0.007). Our report suggests that allo-HSCT offers the best opportunity to improve long-term outcome among patients with TP53 m AML." @default.
• W4312077883 created "2023-01-04" @default.
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• W4312077883 date "2022-12-21" @default.
• W4312077883 modified "2023-09-27" @default.
• W4312077883 title "Allogeneic stem cell transplant improves survival after first- or second-line therapy in TP53-mutated acute myeloid leukemia: Results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND)." @default.
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• W4312077883 doi "https://doi.org/10.21203/rs.3.rs-2383293/v1" @default.
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