FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312077989> ?p ?o ?g. }

• W4312077989 abstract "Abstract Background 14-3-3 is a family of conserved proteins that consist of seven isoforms which are highly expressed in the brain, and 14-3-3ζ is one of the isoforms encoded by the YWHAZ gene. Previous studies demonstrated that 14-3-3ζ is deposited in the neurofibrillary tangles of Alzheimer’s disease (AD) brains, and that 14-3-3ζ interacts with tau from the purified neurofibrillary tangles of AD brain extract. Methods The present study examined the cerebrospinal fluid (CSF) 14-3-3ζ levels of 719 participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), including cognitively normal (CN) participants, patients with mild cognitive impairment (MCI) and patients with AD dementia. Associations between fluid biomarkers of AD (Aβ and tau pathologies, neurodegeneration, synaptic dysfunction and neuroinflammation) with CSF 14-3-3ζ were tested by linear regression models, adjusted by age, sex, years of education and APOE ε4 status. Linear mixed-effect models evaluated how baseline CSF 14-3-3ζ levels predict the changes of cognition scores and neuroimaging findings over time. Cox proportional hazards models assessed how baseline CSF 14-3-3ζ levels influence the relative risk of progression to AD in patients with MCI. Results CSF 14-3-3ζ levels were increased in prodromal AD, and further elevated in AD dementia stage. CSF 14-3-3ζ levels were associated with CSF phosphorylated tau 181(p-tau) and plasma p-tau, which are fluid biomarkers of tau pathology, and could predict tau positive status with high accuracy (area under the receiver operating characteristic curve [AUC], 0.891). CSF 14-3-3ζ levels were also associated with cognitive measurements and neuroimaging findings both at baseline and during follow up, and high CSF 14-3-3ζ levels were associated with subsequent progression to AD dementia in patients with MCI. Conclusions This study suggests that CSF 14-3-3ζ is a potential diagnostic and prognostic biomarker of AD that may be useful in clinical practice." @default.
• W4312077989 created "2023-01-04" @default.
• W4312077989 creator A5002643397 @default.
• W4312077989 creator A5016230283 @default.
• W4312077989 creator A5019560469 @default.
• W4312077989 creator A5048034742 @default.
• W4312077989 creator A5064559018 @default.
• W4312077989 creator A5081658963 @default.
• W4312077989 date "2022-12-21" @default.
• W4312077989 modified "2023-09-25" @default.
• W4312077989 title "CSF 14-3-3ζ is associated with tau pathology and elevated across the Alzheimer’s disease continuum" @default.
• W4312077989 cites W1547515010 @default.
• W4312077989 cites W1972025839 @default.
• W4312077989 cites W1996818295 @default.
• W4312077989 cites W1997816650 @default.
• W4312077989 cites W1998283543 @default.
• W4312077989 cites W1998568988 @default.
• W4312077989 cites W2005924979 @default.
• W4312077989 cites W2065749011 @default.
• W4312077989 cites W2072529095 @default.
• W4312077989 cites W2078524519 @default.
• W4312077989 cites W2090924311 @default.
• W4312077989 cites W2094537612 @default.
• W4312077989 cites W2111951761 @default.
• W4312077989 cites W2122328291 @default.
• W4312077989 cites W2128228199 @default.
• W4312077989 cites W2155277084 @default.
• W4312077989 cites W2161737267 @default.
• W4312077989 cites W2265799967 @default.
• W4312077989 cites W2289098957 @default.
• W4312077989 cites W2517780211 @default.
• W4312077989 cites W2600914407 @default.
• W4312077989 cites W2736518852 @default.
• W4312077989 cites W2736563540 @default.
• W4312077989 cites W2737811824 @default.
• W4312077989 cites W2752344732 @default.
• W4312077989 cites W2763357161 @default.
• W4312077989 cites W2789976306 @default.
• W4312077989 cites W2798054687 @default.
• W4312077989 cites W2801579014 @default.
• W4312077989 cites W2808672296 @default.
• W4312077989 cites W2897287578 @default.
• W4312077989 cites W2904433122 @default.
• W4312077989 cites W2911811341 @default.
• W4312077989 cites W2996482231 @default.
• W4312077989 cites W3018431352 @default.
• W4312077989 cites W3037077603 @default.
• W4312077989 cites W3093903285 @default.
• W4312077989 cites W3191044320 @default.
• W4312077989 cites W3194048913 @default.
• W4312077989 cites W4306410981 @default.
• W4312077989 doi "https://doi.org/10.21203/rs.3.rs-2229567/v2" @default.
• W4312077989 hasPublicationYear "2022" @default.
• W4312077989 type Work @default.
• W4312077989 citedByCount "0" @default.
• W4312077989 crossrefType "posted-content" @default.
• W4312077989 hasAuthorship W4312077989A5002643397 @default.
• W4312077989 hasAuthorship W4312077989A5016230283 @default.
• W4312077989 hasAuthorship W4312077989A5019560469 @default.
• W4312077989 hasAuthorship W4312077989A5048034742 @default.
• W4312077989 hasAuthorship W4312077989A5064559018 @default.
• W4312077989 hasAuthorship W4312077989A5081658963 @default.
• W4312077989 hasBestOaLocation W43120779891 @default.
• W4312077989 hasConcept C126322002 @default.
• W4312077989 hasConcept C142724271 @default.
• W4312077989 hasConcept C143998085 @default.
• W4312077989 hasConcept C15744967 @default.
• W4312077989 hasConcept C169760540 @default.
• W4312077989 hasConcept C2776925932 @default.
• W4312077989 hasConcept C2778373026 @default.
• W4312077989 hasConcept C2778670691 @default.
• W4312077989 hasConcept C2779134260 @default.
• W4312077989 hasConcept C2779483572 @default.
• W4312077989 hasConcept C2779651940 @default.
• W4312077989 hasConcept C502032728 @default.
• W4312077989 hasConcept C58693492 @default.
• W4312077989 hasConcept C71924100 @default.
• W4312077989 hasConcept C87753298 @default.
• W4312077989 hasConceptScore W4312077989C126322002 @default.
• W4312077989 hasConceptScore W4312077989C142724271 @default.
• W4312077989 hasConceptScore W4312077989C143998085 @default.
• W4312077989 hasConceptScore W4312077989C15744967 @default.
• W4312077989 hasConceptScore W4312077989C169760540 @default.
• W4312077989 hasConceptScore W4312077989C2776925932 @default.
• W4312077989 hasConceptScore W4312077989C2778373026 @default.
• W4312077989 hasConceptScore W4312077989C2778670691 @default.
• W4312077989 hasConceptScore W4312077989C2779134260 @default.
• W4312077989 hasConceptScore W4312077989C2779483572 @default.
• W4312077989 hasConceptScore W4312077989C2779651940 @default.
• W4312077989 hasConceptScore W4312077989C502032728 @default.
• W4312077989 hasConceptScore W4312077989C58693492 @default.
• W4312077989 hasConceptScore W4312077989C71924100 @default.
• W4312077989 hasConceptScore W4312077989C87753298 @default.
• W4312077989 hasLocation W43120779891 @default.
• W4312077989 hasOpenAccess W4312077989 @default.
• W4312077989 hasPrimaryLocation W43120779891 @default.
• W4312077989 hasRelatedWork W2024380030 @default.
• W4312077989 hasRelatedWork W2069277654 @default.
• W4312077989 hasRelatedWork W2085558649 @default.
• W4312077989 hasRelatedWork W2102383185 @default.

• next