Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312078556> ?p ?o ?g. }
- W4312078556 abstract "Many diseases of the central nervous system are age-associated and do not directly result from genetic mutations. These include late-onset neurodegenerative diseases (NDDs), which represent a challenge for biomedical research and drug development due to the impossibility to access to viable human brain specimens. Advancements in reprogramming technologies have allowed to obtain neurons from induced pluripotent stem cells (iPSCs) or directly from somatic cells (iNs), leading to the generation of better models to understand the molecular mechanisms and design of new drugs. Nevertheless, iPSC technology faces some limitations due to reprogramming-associated cellular rejuvenation which resets the aging hallmarks of donor cells. Given the prominent role of aging for the development and manifestation of late-onset NDDs, this suggests that this approach is not the most suitable to accurately model age-related diseases. Direct neuronal reprogramming, by which a neuron is formed via direct conversion from a somatic cell without going through a pluripotent intermediate stage, allows the possibility to generate patient-derived neurons that maintain aging and epigenetic signatures of the donor. This aspect may be advantageous for investigating the role of aging in neurodegeneration and for finely dissecting underlying pathological mechanisms. Here, we will compare iPSC and iN models as regards the aging status and explore how this difference is reported to affect the phenotype of NDD in vitro models." @default.
- W4312078556 created "2023-01-04" @default.
- W4312078556 creator A5020150945 @default.
- W4312078556 creator A5053171470 @default.
- W4312078556 creator A5077734880 @default.
- W4312078556 date "2022-12-20" @default.
- W4312078556 modified "2023-10-14" @default.
- W4312078556 title "Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures" @default.
- W4312078556 cites W1409733212 @default.
- W4312078556 cites W1497938915 @default.
- W4312078556 cites W1806909159 @default.
- W4312078556 cites W1815740324 @default.
- W4312078556 cites W1843728946 @default.
- W4312078556 cites W1932303130 @default.
- W4312078556 cites W1935339094 @default.
- W4312078556 cites W1972766500 @default.
- W4312078556 cites W1972975669 @default.
- W4312078556 cites W1974047233 @default.
- W4312078556 cites W1977049211 @default.
- W4312078556 cites W1979892065 @default.
- W4312078556 cites W1986058969 @default.
- W4312078556 cites W1987167495 @default.
- W4312078556 cites W1987885447 @default.
- W4312078556 cites W1998946448 @default.
- W4312078556 cites W2001419937 @default.
- W4312078556 cites W2003126320 @default.
- W4312078556 cites W2003835684 @default.
- W4312078556 cites W2017984491 @default.
- W4312078556 cites W2018392082 @default.
- W4312078556 cites W2019229253 @default.
- W4312078556 cites W2020089910 @default.
- W4312078556 cites W2021667351 @default.
- W4312078556 cites W2028490774 @default.
- W4312078556 cites W2029984090 @default.
- W4312078556 cites W2030396039 @default.
- W4312078556 cites W2033234465 @default.
- W4312078556 cites W2037438288 @default.
- W4312078556 cites W2039551265 @default.
- W4312078556 cites W2048266866 @default.
- W4312078556 cites W2048376696 @default.
- W4312078556 cites W2057641653 @default.
- W4312078556 cites W2067015275 @default.
- W4312078556 cites W2068478010 @default.
- W4312078556 cites W2072859865 @default.
- W4312078556 cites W2075975173 @default.
- W4312078556 cites W2079870118 @default.
- W4312078556 cites W2081628067 @default.
- W4312078556 cites W2081914422 @default.
- W4312078556 cites W2082223061 @default.
- W4312078556 cites W2087786585 @default.
- W4312078556 cites W2088714934 @default.
- W4312078556 cites W2105151327 @default.
- W4312078556 cites W2114206069 @default.
- W4312078556 cites W2114840727 @default.
- W4312078556 cites W2119508244 @default.
- W4312078556 cites W2125987139 @default.
- W4312078556 cites W2127394968 @default.
- W4312078556 cites W2130128490 @default.
- W4312078556 cites W2131108668 @default.
- W4312078556 cites W2133496762 @default.
- W4312078556 cites W2134718821 @default.
- W4312078556 cites W2135149410 @default.
- W4312078556 cites W2136541538 @default.
- W4312078556 cites W2138574694 @default.
- W4312078556 cites W2138977668 @default.
- W4312078556 cites W2139693494 @default.
- W4312078556 cites W2146890924 @default.
- W4312078556 cites W2147718170 @default.
- W4312078556 cites W2152642144 @default.
- W4312078556 cites W2152712492 @default.
- W4312078556 cites W2156640524 @default.
- W4312078556 cites W2157073241 @default.
- W4312078556 cites W2157642912 @default.
- W4312078556 cites W2159422594 @default.
- W4312078556 cites W2161224111 @default.
- W4312078556 cites W2163327652 @default.
- W4312078556 cites W2164814910 @default.
- W4312078556 cites W2167253194 @default.
- W4312078556 cites W2170356111 @default.
- W4312078556 cites W2212633910 @default.
- W4312078556 cites W2268912752 @default.
- W4312078556 cites W2320402074 @default.
- W4312078556 cites W2415866521 @default.
- W4312078556 cites W2484951111 @default.
- W4312078556 cites W2521543069 @default.
- W4312078556 cites W2534142475 @default.
- W4312078556 cites W2542949518 @default.
- W4312078556 cites W2607440944 @default.
- W4312078556 cites W2613062475 @default.
- W4312078556 cites W2734622199 @default.
- W4312078556 cites W2757770411 @default.
- W4312078556 cites W2765408167 @default.
- W4312078556 cites W2766617104 @default.
- W4312078556 cites W2769598455 @default.
- W4312078556 cites W2790780682 @default.
- W4312078556 cites W2796559433 @default.
- W4312078556 cites W2803698569 @default.
- W4312078556 cites W2805679083 @default.
- W4312078556 cites W2891962606 @default.
- W4312078556 cites W2893893071 @default.