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• W4312078617 endingPage "1" @default.
• W4312078617 startingPage "1" @default.
• W4312078617 abstract "NMDA-type glutamate receptors are critical for synaptic plasticity in the central nervous system. Their unique properties and age-dependent arrangement of subunit types underpin their role as a coincidence detector of pre- and postsynaptic activity during brain development and maturation. NMDAR function is highly modulated by zinc, which is co-released with glutamate and concentrates in postsynaptic spines. Both NMDARs and zinc have been strongly linked to autism spectrum disorders (ASDs), suggesting that NMDARs are an important player in the beneficial effects observed with zinc in both animal models and children with ASDs. Significant evidence is emerging that these beneficial effects occur via zinc-dependent regulation of SHANK proteins, which form the backbone of the postsynaptic density. For example, dietary zinc supplementation enhances SHANK2 or SHANK3 synaptic recruitment and rescues NMDAR deficits and hypofunction in Shank3ex13-16-/- and Tbr1+/- ASD mice. Across multiple studies, synaptic changes occur in parallel with a reversal of ASD-associated behaviours, highlighting the zinc-dependent regulation of NMDARs and glutamatergic synapses as therapeutic targets for severe forms of ASDs, either pre- or postnatally. The data from rodent models set a strong foundation for future translational studies in human cells and people affected by ASDs." @default.
• W4312078617 created "2023-01-04" @default.
• W4312078617 creator A5005109527 @default.
• W4312078617 creator A5009444223 @default.
• W4312078617 creator A5038464425 @default.
• W4312078617 creator A5052334128 @default.
• W4312078617 creator A5085703673 @default.
• W4312078617 date "2022-12-20" @default.
• W4312078617 modified "2023-10-14" @default.
• W4312078617 title "The Role of Zinc and NMDA Receptors in Autism Spectrum Disorders" @default.
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