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- W4312080204 abstract "Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are genetic disorders affecting skeletal and smooth muscle, heart, brain, eyes, and other organs. The multisystem involvement and disease variability of myotonic dystrophy have presented challenges for clinical care and research. This article focuses on the diagnosis and management of the disease. In addition, recent advances in characterizing the diverse clinical manifestations and variability of the disease are discussed.Studies of the multisystem involvement of myotonic dystrophy, including the most lethal cardiac and respiratory manifestations and their molecular underpinnings, expand our understanding of the myotonic dystrophy phenotype. Advances have been made in understanding the molecular mechanisms of both types of myotonic dystrophy, providing opportunities for developing targeted therapeutics, some of which have entered clinical trials in DM1.Continued efforts focus on advancing our molecular and clinical understanding of DM1 and DM2. Accurately measuring and monitoring the diverse and variable clinical manifestations of myotonic dystrophy in clinic and in research is important to provide adequate care, prevent complications, and find treatments that improve symptoms and life quality." @default.
- W4312080204 created "2023-01-04" @default.
- W4312080204 creator A5069557229 @default.
- W4312080204 date "2022-12-01" @default.
- W4312080204 modified "2023-10-06" @default.
- W4312080204 title "Myotonic Dystrophy" @default.
- W4312080204 cites W1555409852 @default.
- W4312080204 cites W1876786915 @default.
- W4312080204 cites W1967277020 @default.
- W4312080204 cites W1968799186 @default.
- W4312080204 cites W1972049262 @default.
- W4312080204 cites W1990604299 @default.
- W4312080204 cites W1994674028 @default.
- W4312080204 cites W2008930397 @default.
- W4312080204 cites W2009455879 @default.
- W4312080204 cites W2013047118 @default.
- W4312080204 cites W2023413536 @default.
- W4312080204 cites W2030663973 @default.
- W4312080204 cites W2034282803 @default.
- W4312080204 cites W2035552488 @default.
- W4312080204 cites W2042867532 @default.
- W4312080204 cites W2043044683 @default.
- W4312080204 cites W2049198969 @default.
- W4312080204 cites W2051581982 @default.
- W4312080204 cites W2052369671 @default.
- W4312080204 cites W2055622619 @default.
- W4312080204 cites W2055947823 @default.
- W4312080204 cites W2056227811 @default.
- W4312080204 cites W2069882113 @default.
- W4312080204 cites W2072254270 @default.
- W4312080204 cites W2083028245 @default.
- W4312080204 cites W2093521734 @default.
- W4312080204 cites W2098214510 @default.
- W4312080204 cites W2101788267 @default.
- W4312080204 cites W2102986002 @default.
- W4312080204 cites W2103116226 @default.
- W4312080204 cites W2113918626 @default.
- W4312080204 cites W2117000474 @default.
- W4312080204 cites W2126628291 @default.
- W4312080204 cites W2127487162 @default.
- W4312080204 cites W2131447660 @default.
- W4312080204 cites W2141124826 @default.
- W4312080204 cites W2141427674 @default.
- W4312080204 cites W2297319326 @default.
- W4312080204 cites W2321918414 @default.
- W4312080204 cites W2325022937 @default.
- W4312080204 cites W2334333093 @default.
- W4312080204 cites W2411405659 @default.
- W4312080204 cites W2558442817 @default.
- W4312080204 cites W2578947421 @default.
- W4312080204 cites W2593499094 @default.
- W4312080204 cites W2599607200 @default.
- W4312080204 cites W2603386070 @default.
- W4312080204 cites W2736548093 @default.
- W4312080204 cites W2738013241 @default.
- W4312080204 cites W2742741050 @default.
- W4312080204 cites W2747114010 @default.
- W4312080204 cites W2753249033 @default.
- W4312080204 cites W2753271204 @default.
- W4312080204 cites W2756089374 @default.
- W4312080204 cites W2758877381 @default.
- W4312080204 cites W2764314777 @default.
- W4312080204 cites W2766547598 @default.
- W4312080204 cites W2775921266 @default.
- W4312080204 cites W2778586360 @default.
- W4312080204 cites W2779762845 @default.
- W4312080204 cites W2790174515 @default.
- W4312080204 cites W2791694547 @default.
- W4312080204 cites W2793473509 @default.
- W4312080204 cites W2794475571 @default.
- W4312080204 cites W2795205830 @default.
- W4312080204 cites W2795765276 @default.
- W4312080204 cites W2803409498 @default.
- W4312080204 cites W2807883496 @default.
- W4312080204 cites W2808051836 @default.
- W4312080204 cites W2809235578 @default.
- W4312080204 cites W2810377318 @default.
- W4312080204 cites W2884038518 @default.
- W4312080204 cites W2889530657 @default.
- W4312080204 cites W2889618751 @default.
- W4312080204 cites W2890350848 @default.
- W4312080204 cites W2899112271 @default.
- W4312080204 cites W2900203963 @default.
- W4312080204 cites W2903586694 @default.
- W4312080204 cites W2905021938 @default.
- W4312080204 cites W2909852424 @default.
- W4312080204 cites W2914772283 @default.
- W4312080204 cites W2916588112 @default.
- W4312080204 cites W2917869878 @default.
- W4312080204 cites W2922412172 @default.
- W4312080204 cites W2931529860 @default.
- W4312080204 cites W2942414385 @default.
- W4312080204 cites W2944951223 @default.
- W4312080204 cites W2968617726 @default.
- W4312080204 cites W2972734091 @default.
- W4312080204 cites W3092025205 @default.
- W4312080204 cites W3109370673 @default.
- W4312080204 cites W3116332102 @default.