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- W4312080212 abstract "Neurodegeneration has been proven to represent a critical element of diabetic retinopathy (DR) pathogenesis. The neuronal involvement is subclinical, engaging in the early phases of diabetic retinopathy, and contributes to the further microvascular impairment and blood-retinal barrier breakdown. The importance of neurodegeneration resides in the possibility of targeting neuronal apoptosis as an early intervention to slow and prevent the development of microvascular alterations visible on clinical examination. This presentation summarizes the multimodal imaging features and functional tests helpful in identifying neuronal damage in a subclinical stage before recognizing DR signs. Clinical features of neurodegeneration are crucial in identifying high-risk patients to develop a vascular impairment and thus serve as outcome measures to understand the efficacy of supplementation. The potential approach for targeting neurodegeneration that includes topical compounds acting on different elements of the pathogenic cascade will be discussed. Further, the current evidence and clinical trials performed on humans will be examined, including the three main topical agents tested, brimonidine, somatostatin, and citicoline, with promising results." @default.
- W4312080212 created "2023-01-04" @default.
- W4312080212 creator A5009105924 @default.
- W4312080212 date "2022-12-01" @default.
- W4312080212 modified "2023-09-25" @default.
- W4312080212 title "Targeting neuroinflammation in early diabetic retinopathy" @default.
- W4312080212 doi "https://doi.org/10.1111/j.1755-3768.2022.15433" @default.
- W4312080212 hasPublicationYear "2022" @default.
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