FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312083212> ?p ?o ?g. }

• W4312083212 abstract "We present a case series of sclerosing epithelioid fibrosarcoma (SEF) to further characterise its clinical and pathological features. Twenty-one patients with SEF were included in this study. There were 12 males and nine females (range 25–63 years; median 38 years). Tumours were located in the kidney (n=5), thigh (n=3), chest wall (n=3), head and neck (n=2), bone (n=2), abdominal wall (n=1), psoas major (n=1), retroperitoneum (n=1), omentum (n=1), popliteal space (n=1) and lung (n=1). Tumour sizes ranged from 2.5 to 16 cm (median 7 cm). Microscopically, epithelioid tumour cells were arranged in nests and cords and embedded in a dense sclerotic stroma. Some tumours showed myxoid areas, fibroma-like areas, acinar growth patterns and haemangiopericytoma-like appearance. A few tumour cells presented a rhabdomyoid shape. Calcification, ossification, cystic and necrosis were observed in some cases. The diagnosis was confirmed by immunoreactivity for MUC4, and by further fluorescence in situ hybridisation (FISH) or next generation sequencing (NGS) analysis. Clinical follow-up was available for 16 cases (median, 24 months; range 6–62 months). Seven patients developed metastases to lung (n=3), bone (n=3), brain (n=2) and back (n=1). Four patients developed a local recurrence. Three patients died of disease. Overall survival (OS) of SEF was related to patient age (p=0.001) and progression-free survival (PFS) was related to tumour size (p=0.046). In addition to soft tissue, SEF is more likely to involve the viscera and the abdominal cavity and has morphological variants. Familiarity with its distinctive clinical and pathological features helps avoid misdiagnosis. We present a case series of sclerosing epithelioid fibrosarcoma (SEF) to further characterise its clinical and pathological features. Twenty-one patients with SEF were included in this study. There were 12 males and nine females (range 25–63 years; median 38 years). Tumours were located in the kidney (n=5), thigh (n=3), chest wall (n=3), head and neck (n=2), bone (n=2), abdominal wall (n=1), psoas major (n=1), retroperitoneum (n=1), omentum (n=1), popliteal space (n=1) and lung (n=1). Tumour sizes ranged from 2.5 to 16 cm (median 7 cm). Microscopically, epithelioid tumour cells were arranged in nests and cords and embedded in a dense sclerotic stroma. Some tumours showed myxoid areas, fibroma-like areas, acinar growth patterns and haemangiopericytoma-like appearance. A few tumour cells presented a rhabdomyoid shape. Calcification, ossification, cystic and necrosis were observed in some cases. The diagnosis was confirmed by immunoreactivity for MUC4, and by further fluorescence in situ hybridisation (FISH) or next generation sequencing (NGS) analysis. Clinical follow-up was available for 16 cases (median, 24 months; range 6–62 months). Seven patients developed metastases to lung (n=3), bone (n=3), brain (n=2) and back (n=1). Four patients developed a local recurrence. Three patients died of disease. Overall survival (OS) of SEF was related to patient age (p=0.001) and progression-free survival (PFS) was related to tumour size (p=0.046). In addition to soft tissue, SEF is more likely to involve the viscera and the abdominal cavity and has morphological variants. Familiarity with its distinctive clinical and pathological features helps avoid misdiagnosis." @default.
• W4312083212 created "2023-01-04" @default.
• W4312083212 creator A5010607078 @default.
• W4312083212 creator A5013057484 @default.
• W4312083212 creator A5023606351 @default.
• W4312083212 creator A5032764121 @default.
• W4312083212 creator A5035639953 @default.
• W4312083212 creator A5045040311 @default.
• W4312083212 creator A5053780153 @default.
• W4312083212 creator A5070575002 @default.
• W4312083212 creator A5090366405 @default.
• W4312083212 date "2022-12-01" @default.
• W4312083212 modified "2023-09-25" @default.
• W4312083212 title "The clinicopathological spectrum of sclerosing epithelioid fibrosarcoma: report of an additional series with review of the literature" @default.
• W4312083212 cites W1809783022 @default.
• W4312083212 cites W1998036629 @default.
• W4312083212 cites W2015890622 @default.
• W4312083212 cites W2019419432 @default.
• W4312083212 cites W2021444139 @default.
• W4312083212 cites W2028292090 @default.
• W4312083212 cites W2057600822 @default.
• W4312083212 cites W2073769857 @default.
• W4312083212 cites W2096699164 @default.
• W4312083212 cites W2163643703 @default.
• W4312083212 cites W2605508826 @default.
• W4312083212 cites W2725806461 @default.
• W4312083212 cites W2756507357 @default.
• W4312083212 cites W2889956456 @default.
• W4312083212 cites W2908877021 @default.
• W4312083212 cites W2913111587 @default.
• W4312083212 cites W2916732436 @default.
• W4312083212 cites W2972961795 @default.
• W4312083212 cites W2979392450 @default.
• W4312083212 cites W2988740248 @default.
• W4312083212 cites W2989758016 @default.
• W4312083212 cites W2999074861 @default.
• W4312083212 cites W3048404111 @default.
• W4312083212 cites W3089312509 @default.
• W4312083212 cites W3121669675 @default.
• W4312083212 cites W3164724467 @default.
• W4312083212 cites W4233393745 @default.
• W4312083212 doi "https://doi.org/10.1016/j.pathol.2022.10.005" @default.
• W4312083212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36690575" @default.
• W4312083212 hasPublicationYear "2022" @default.
• W4312083212 type Work @default.
• W4312083212 citedByCount "1" @default.
• W4312083212 countsByYear W43120832122023 @default.
• W4312083212 crossrefType "journal-article" @default.
• W4312083212 hasAuthorship W4312083212A5010607078 @default.
• W4312083212 hasAuthorship W4312083212A5013057484 @default.
• W4312083212 hasAuthorship W4312083212A5023606351 @default.
• W4312083212 hasAuthorship W4312083212A5032764121 @default.
• W4312083212 hasAuthorship W4312083212A5035639953 @default.
• W4312083212 hasAuthorship W4312083212A5045040311 @default.
• W4312083212 hasAuthorship W4312083212A5053780153 @default.
• W4312083212 hasAuthorship W4312083212A5070575002 @default.
• W4312083212 hasAuthorship W4312083212A5090366405 @default.
• W4312083212 hasConcept C105702510 @default.
• W4312083212 hasConcept C118441373 @default.
• W4312083212 hasConcept C126322002 @default.
• W4312083212 hasConcept C136948725 @default.
• W4312083212 hasConcept C142724271 @default.
• W4312083212 hasConcept C204232928 @default.
• W4312083212 hasConcept C2776495794 @default.
• W4312083212 hasConcept C2777193977 @default.
• W4312083212 hasConcept C2777714996 @default.
• W4312083212 hasConcept C2779018429 @default.
• W4312083212 hasConcept C2780309369 @default.
• W4312083212 hasConcept C71924100 @default.
• W4312083212 hasConceptScore W4312083212C105702510 @default.
• W4312083212 hasConceptScore W4312083212C118441373 @default.
• W4312083212 hasConceptScore W4312083212C126322002 @default.
• W4312083212 hasConceptScore W4312083212C136948725 @default.
• W4312083212 hasConceptScore W4312083212C142724271 @default.
• W4312083212 hasConceptScore W4312083212C204232928 @default.
• W4312083212 hasConceptScore W4312083212C2776495794 @default.
• W4312083212 hasConceptScore W4312083212C2777193977 @default.
• W4312083212 hasConceptScore W4312083212C2777714996 @default.
• W4312083212 hasConceptScore W4312083212C2779018429 @default.
• W4312083212 hasConceptScore W4312083212C2780309369 @default.
• W4312083212 hasConceptScore W4312083212C71924100 @default.
• W4312083212 hasLocation W43120832121 @default.
• W4312083212 hasLocation W43120832122 @default.
• W4312083212 hasOpenAccess W4312083212 @default.
• W4312083212 hasPrimaryLocation W43120832121 @default.
• W4312083212 hasRelatedWork W1987149745 @default.
• W4312083212 hasRelatedWork W2050414093 @default.
• W4312083212 hasRelatedWork W2150263336 @default.
• W4312083212 hasRelatedWork W2189152683 @default.
• W4312083212 hasRelatedWork W2217710185 @default.
• W4312083212 hasRelatedWork W2239167533 @default.
• W4312083212 hasRelatedWork W2351242654 @default.
• W4312083212 hasRelatedWork W2981604361 @default.
• W4312083212 hasRelatedWork W3016782864 @default.
• W4312083212 hasRelatedWork W4312083212 @default.
• W4312083212 isParatext "false" @default.
• W4312083212 isRetracted "false" @default.
• W4312083212 workType "article" @default.