Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312084893> ?p ?o ?g. }
- W4312084893 endingPage "111848" @default.
- W4312084893 startingPage "111848" @default.
- W4312084893 abstract "Cerebral small vessel disease and brain white matter injury are worsened by cardiovascular risk factors including obesity. Molecular pathways in cerebral endothelial cells activated by chronic cerebrovascular risk factors alter cell-cell signaling, blocking endogenous and post-ischemic white matter repair. Using cell-specific translating ribosome affinity purification (RiboTag) in white matter endothelia and oligodendrocyte progenitor cells (OPCs), we identify a coordinated interleukin-chemokine signaling cascade within the oligovascular niche of subcortical white matter that is triggered by diet-induced obesity (DIO). DIO induces interleukin-17B (IL-17B) signaling that acts on the cerebral endothelia through IL-17Rb to increase both circulating and local endothelial expression of CXCL5. In white matter endothelia, CXCL5 promotes the association of OPCs with the vasculature and triggers OPC gene expression programs regulating cell migration through chemokine signaling. Targeted blockade of IL-17B reduced vessel-associated OPCs by reducing endothelial CXCL5 expression. In multiple human cohorts, blood levels of CXCL5 function as a diagnostic and prognostic biomarker of vascular cognitive impairment." @default.
- W4312084893 created "2023-01-04" @default.
- W4312084893 creator A5000212230 @default.
- W4312084893 creator A5004041923 @default.
- W4312084893 creator A5006920232 @default.
- W4312084893 creator A5008519123 @default.
- W4312084893 creator A5020468723 @default.
- W4312084893 creator A5032898272 @default.
- W4312084893 creator A5038796731 @default.
- W4312084893 creator A5040650353 @default.
- W4312084893 creator A5044380303 @default.
- W4312084893 creator A5046295476 @default.
- W4312084893 creator A5049182488 @default.
- W4312084893 creator A5053743900 @default.
- W4312084893 creator A5064536213 @default.
- W4312084893 creator A5065465113 @default.
- W4312084893 creator A5067515668 @default.
- W4312084893 creator A5068141074 @default.
- W4312084893 creator A5070598734 @default.
- W4312084893 creator A5072579623 @default.
- W4312084893 creator A5079206777 @default.
- W4312084893 date "2022-12-01" @default.
- W4312084893 modified "2023-09-27" @default.
- W4312084893 title "IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury" @default.
- W4312084893 cites W1978204915 @default.
- W4312084893 cites W1988328354 @default.
- W4312084893 cites W1993981485 @default.
- W4312084893 cites W1996120720 @default.
- W4312084893 cites W1997038422 @default.
- W4312084893 cites W2002667055 @default.
- W4312084893 cites W2005217615 @default.
- W4312084893 cites W2020233428 @default.
- W4312084893 cites W2020384941 @default.
- W4312084893 cites W2023663258 @default.
- W4312084893 cites W2027585733 @default.
- W4312084893 cites W2031378857 @default.
- W4312084893 cites W2035449167 @default.
- W4312084893 cites W2038429516 @default.
- W4312084893 cites W2038963685 @default.
- W4312084893 cites W2040490781 @default.
- W4312084893 cites W2054275187 @default.
- W4312084893 cites W2063011052 @default.
- W4312084893 cites W2072290762 @default.
- W4312084893 cites W2072528436 @default.
- W4312084893 cites W2074441702 @default.
- W4312084893 cites W2074978325 @default.
- W4312084893 cites W2076382866 @default.
- W4312084893 cites W2078538955 @default.
- W4312084893 cites W2089867460 @default.
- W4312084893 cites W2095090377 @default.
- W4312084893 cites W2106961136 @default.
- W4312084893 cites W2120902612 @default.
- W4312084893 cites W2122477279 @default.
- W4312084893 cites W2133188899 @default.
- W4312084893 cites W2136800398 @default.
- W4312084893 cites W2136999338 @default.
- W4312084893 cites W2137101124 @default.
- W4312084893 cites W2140075426 @default.
- W4312084893 cites W2143372911 @default.
- W4312084893 cites W2145490597 @default.
- W4312084893 cites W2146152985 @default.
- W4312084893 cites W2148268384 @default.
- W4312084893 cites W2148631338 @default.
- W4312084893 cites W2153633999 @default.
- W4312084893 cites W2159482845 @default.
- W4312084893 cites W2166419090 @default.
- W4312084893 cites W2167047126 @default.
- W4312084893 cites W2226708402 @default.
- W4312084893 cites W2273567156 @default.
- W4312084893 cites W2279320212 @default.
- W4312084893 cites W2301771266 @default.
- W4312084893 cites W2415341492 @default.
- W4312084893 cites W2540633154 @default.
- W4312084893 cites W2561139731 @default.
- W4312084893 cites W2767408123 @default.
- W4312084893 cites W2811101553 @default.
- W4312084893 cites W2900569176 @default.
- W4312084893 cites W2941593046 @default.
- W4312084893 cites W2967933956 @default.
- W4312084893 cites W2978108048 @default.
- W4312084893 cites W2985308551 @default.
- W4312084893 cites W3003088065 @default.
- W4312084893 cites W3111623592 @default.
- W4312084893 cites W4245761592 @default.
- W4312084893 cites W4294216483 @default.
- W4312084893 cites W2419079236 @default.
- W4312084893 doi "https://doi.org/10.1016/j.celrep.2022.111848" @default.
- W4312084893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36543124" @default.
- W4312084893 hasPublicationYear "2022" @default.
- W4312084893 type Work @default.
- W4312084893 citedByCount "2" @default.
- W4312084893 countsByYear W43120848932023 @default.
- W4312084893 crossrefType "journal-article" @default.
- W4312084893 hasAuthorship W4312084893A5000212230 @default.
- W4312084893 hasAuthorship W4312084893A5004041923 @default.
- W4312084893 hasAuthorship W4312084893A5006920232 @default.
- W4312084893 hasAuthorship W4312084893A5008519123 @default.
- W4312084893 hasAuthorship W4312084893A5020468723 @default.