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• W4312084981 endingPage "120451" @default.
• W4312084981 startingPage "120451" @default.
• W4312084981 abstract "Numerous disseminated tumor cells specifically overexpress P-selectin. Therefore, it was thought to be a potential target for tumor therapy. Herein, we described a novel P-selectin-targeted glycosyl ligand-sulfated polyguluronic acid (PGS), as an oriented carrier of P-selectin-targeted drug delivery system. Specifically, the PGS-SS-DOX polymeric micelles were constructed to confirm the practicability of the PGS carrier as a new P-selectin-targeted ligand. PGS-SS-DOX micelles comprised P-selectin-targeted PGS, doxorubicin (DOX) as an anticarcinogen, and pH/redox dual-sensitive bio-linker facilitating drug release in tumor tissues. In vitro and in vivo data showed that PGS-SS-DOX micelles significantly increased tumor cell killing capacity and exhibited a favorable biocompatibility comparison with Free-DOX. This work proved that PGS was an ideal low immunogenic, biodegradable drug carrier for the delivery of anti-cancer drugs. The facile PGS-SS-drug micelle system provided enormous opportunities for treating disseminated tumors utilizing many irreplaceable anticarcinogens." @default.
• W4312084981 created "2023-01-04" @default.
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• W4312084981 date "2023-03-01" @default.
• W4312084981 modified "2023-10-18" @default.
• W4312084981 title "The development of multifunctional sulfated polyguluronic acid-based polymeric micelles for anticancer drug delivery" @default.
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• W4312084981 doi "https://doi.org/10.1016/j.carbpol.2022.120451" @default.
• W4312084981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36657841" @default.
• W4312084981 hasPublicationYear "2023" @default.
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