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• W4312085020 abstract "A new ceramide named luteaceramide (1), along with sixteen known compounds including 3α-hydroxy-27-p-(E)-coumaroyloxyursan-12-en-28-oic acid (2), 3α-hydroxy-27-p-(Z)-coumaroyloxyursan-12-en-28-oic acid (3), 3-O-acetyl-α-amyrin (4), lupeol (5), a mixture of β-sitosterol (6) and stigmasterol (7), 24-methylenecycloartenol (8), hexacosanol (9), ergosterol 5α,8α-endoperoxide (10), hexatriacontan-1-ol (11), 3β-acetoxy-1β,11α-dihydroxyolean-12-ene (12), palmitic acid (13), tormentic acid (14), alphitolic acid (15), β-sitosterol-3-O-β-D glucopyranoside (16), and ursolazuroside 1 (17) were obtained after phytochemical investigation of the methanol extract of the fruits of Ficus lutea. The structure of the new compound was elucidated by analyses of their spectroscopic data including 1D and 2D-NMR, HREI-MS and chemical conversions. The MeOH crude extract had weak activity against Proteus mirabilis (MIC 2.5 mg/mL). Luteaceramide (1), lupeol (5) and hexacosanol (9) showed a moderate antibacterial activity against Escherichia coli with MIC ranging from 31 to 63 μg/mL while 1 was weakly active against Staphylococcus aureus, Enterococcus faecalis, and P. mirabilis with MIC between 125 and 250 μg/mL. Compounds 2, 3, 12, 14, 15, and 17 are also reported for the first time from the genus Ficus. The chemotaxonomic significance of the isolated compounds was summarized. Our results on the isolation of a new ceramide (1), triterpenoids of ursan (2–4, 14 and 17)-, lupan (5 and 15)-, oleanan (12)-, and cycloartan (8)-types, steroids (6, 7, 10 and 16), alcohols (9 and 11), and a fatty acid (13) from F. lutea Vahl are in good agreement with the classification and the chemotaxonomy of this species for the genus Ficus and for the family Moraceae. The phytochemical analyses of plant species of the genus Ficus in most of the cases provided the isolation of ceramides. This class of secondary metabolites could be considered as one of the markers of the genus Ficus." @default.
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• W4312085020 date "2023-02-01" @default.
• W4312085020 modified "2023-10-01" @default.
• W4312085020 title "A new ceramide and other constituents from the fruits of Ficus lutea Vahl (Moraceae) and their chemotaxonomic significance" @default.
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• W4312085020 doi "https://doi.org/10.1016/j.bse.2022.104573" @default.
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