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• W4312085149 endingPage "104500" @default.
• W4312085149 startingPage "104500" @default.
• W4312085149 abstract "Osteoarthritis (OA) is a chronic and irreversible degenerative joint disease that most commonly affects individuals in their forties and fifties worldwide due to the continuously increasing life expectancy. Although joint replacement is an effective remedy for severe end-stage OA, the functional outcomes could be unsatisfactory, while the implants might have a limited lifespan. Due to the drawbacks and limitations of the joint replacement approach, bone Tissue Engineering (TE) is one of the promising bone tissue regeneration technologies that aid in cartilage repair and regeneration and has attracted the attention of experts. The advanced development of biopolymers, in particular biopolymer derived from Oil Palm Empty Fruit Bunch (OPEFB), has been utilised in the fabrication of scaffolds that serve as a crucial component in bone TE. The abundant supply of OPEFB biomass and the increasing trend of converting waste into wealth for environmental sustainability have also provided the opportunity and interest to fully apply biopolymer-derived materials for bone scaffolding and other applications. Therefore, this paper aimed to provide a review of the biopolymers derived from OPEFB for the treatment of OA and other related applications. A brief overview of the biomass sources in Malaysia was presented, followed by a discussion on the chemical compositions and pre-treatment methods of OPEFB by using organosolv pre-treatment and enzymatic hydrolysis for maximum glucose recovery, monomer derived from cellulose OPEFB and synthesizing self-curing polymer scaffold. Additionally, a detailed review of the polymeric biomaterials in bone TE for the fabrication of scaffolds were included in this review. Most importantly, the paper described the potential use of injectable polymeric biomaterials that provide a significant benefit in orthopaedic applications. Overall, this paper provides a perspective on the potential of OPEFB-derived injectable scaffolds as an alternative OA treatment and future bone TE applications." @default.
• W4312085149 created "2023-01-04" @default.
• W4312085149 creator A5011383530 @default.
• W4312085149 creator A5041592140 @default.
• W4312085149 creator A5057904312 @default.
• W4312085149 creator A5066455003 @default.
• W4312085149 date "2023-02-01" @default.
• W4312085149 modified "2023-10-18" @default.
• W4312085149 title "Synthesising injectable molecular self-curing polymer from monomer derived from lignocellulosic oil palm empty fruit bunch biomass: A review on treating Osteoarthritis" @default.
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