FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312091459> ?p ?o ?g. }

• W4312091459 endingPage "e0279091" @default.
• W4312091459 startingPage "e0279091" @default.
• W4312091459 abstract "Evolutionary history leads to genome changes over time, especially for species that have experienced intense selective pressures over a short period. Here, we investigated the genomic evolution of Bos species by searching for potential selection signatures, focusing on Nelore, an economically relevant cattle breed in Brazil. We assessed the genomic processes determining the molecular evolution across Nelore and thirteen other related taxa by evaluating (i) amino acid sequence conservation, (ii) the dN/dS ratio, and (iii) gene families' turnover rate (λ). Low conserved regions potentially associated with fatty acid metabolism seem to reflect differences in meat fat content in taxa with different evolutionary histories. All Bos species presented genes under positive selection, especially B. indicus and Nelore, which include transport protein cobalamin, glycolipid metabolism, and hormone signaling. These findings could be explained by constant selective pressures to obtain higher immune resistance and efficient metabolism. The gene contraction rate across the Nelore + B. indicus branch was almost nine times higher than that in other lineages (λ = 0.01043 vs. 0.00121), indicating gene losses during the domestication process. Amino acid biosynthesis, reproductive and innate immune system-related pathways were associated with genes recognized within the most frequent rapidly evolving gene families and in genes under positive selection, supporting the substantial relevance of such traits from a domestication perspective. Our data provide new insights into how the genome may respond to intense artificial selection in distinct taxa, and reinforces the presence of selective pressures on traits potentially relevant for future animal breeding investments." @default.
• W4312091459 created "2023-01-04" @default.
• W4312091459 creator A5007059750 @default.
• W4312091459 creator A5021237764 @default.
• W4312091459 creator A5060027133 @default.
• W4312091459 creator A5080529521 @default.
• W4312091459 creator A5085776207 @default.
• W4312091459 date "2022-12-22" @default.
• W4312091459 modified "2023-10-18" @default.
• W4312091459 title "Molecular evolution and signatures of selective pressures on Bos, focusing on the Nelore breed (Bos indicus)" @default.
• W4312091459 cites W1504884634 @default.
• W4312091459 cites W1508885706 @default.
• W4312091459 cites W156481159 @default.
• W4312091459 cites W1831444480 @default.
• W4312091459 cites W1966010303 @default.
• W4312091459 cites W1967137493 @default.
• W4312091459 cites W1969353942 @default.
• W4312091459 cites W1978545896 @default.
• W4312091459 cites W1984271382 @default.
• W4312091459 cites W1985136948 @default.
• W4312091459 cites W1993038297 @default.
• W4312091459 cites W2008126923 @default.
• W4312091459 cites W2008856488 @default.
• W4312091459 cites W2016370482 @default.
• W4312091459 cites W2036027854 @default.
• W4312091459 cites W2038740993 @default.
• W4312091459 cites W2041624900 @default.
• W4312091459 cites W2045326981 @default.
• W4312091459 cites W2055043387 @default.
• W4312091459 cites W2057894845 @default.
• W4312091459 cites W2057960948 @default.
• W4312091459 cites W2064974190 @default.
• W4312091459 cites W2068952795 @default.
• W4312091459 cites W2078017327 @default.
• W4312091459 cites W2079989614 @default.
• W4312091459 cites W2085625934 @default.
• W4312091459 cites W2088108488 @default.
• W4312091459 cites W2095829109 @default.
• W4312091459 cites W2097977090 @default.
• W4312091459 cites W2098223336 @default.
• W4312091459 cites W2103581172 @default.
• W4312091459 cites W2106781718 @default.
• W4312091459 cites W2115888213 @default.
• W4312091459 cites W2117204353 @default.
• W4312091459 cites W2119080840 @default.
• W4312091459 cites W2122821321 @default.
• W4312091459 cites W2123044623 @default.
• W4312091459 cites W2123886461 @default.
• W4312091459 cites W2124166542 @default.
• W4312091459 cites W2125623193 @default.
• W4312091459 cites W2126419817 @default.
• W4312091459 cites W2129668670 @default.
• W4312091459 cites W2130025116 @default.
• W4312091459 cites W2137665051 @default.
• W4312091459 cites W2141052558 @default.
• W4312091459 cites W2144368480 @default.
• W4312091459 cites W2149173660 @default.
• W4312091459 cites W2153530957 @default.
• W4312091459 cites W2160378127 @default.
• W4312091459 cites W2164154943 @default.
• W4312091459 cites W2170747616 @default.
• W4312091459 cites W2279411665 @default.
• W4312091459 cites W2315897244 @default.
• W4312091459 cites W2317094502 @default.
• W4312091459 cites W2626926348 @default.
• W4312091459 cites W2747842027 @default.
• W4312091459 cites W2786180981 @default.
• W4312091459 cites W2790517927 @default.
• W4312091459 cites W2794265469 @default.
• W4312091459 cites W2810621866 @default.
• W4312091459 cites W2885297363 @default.
• W4312091459 cites W2892101268 @default.
• W4312091459 cites W2904400044 @default.
• W4312091459 cites W2941072767 @default.
• W4312091459 cites W2995640339 @default.
• W4312091459 cites W3005235420 @default.
• W4312091459 cites W3043232254 @default.
• W4312091459 cites W3103732873 @default.
• W4312091459 cites W3113087152 @default.
• W4312091459 cites W3195155884 @default.
• W4312091459 cites W4233734352 @default.
• W4312091459 cites W633042482 @default.
• W4312091459 cites W97059505 @default.
• W4312091459 cites W3140746974 @default.
• W4312091459 doi "https://doi.org/10.1371/journal.pone.0279091" @default.
• W4312091459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36548260" @default.
• W4312091459 hasPublicationYear "2022" @default.
• W4312091459 type Work @default.
• W4312091459 citedByCount "0" @default.
• W4312091459 crossrefType "journal-article" @default.
• W4312091459 hasAuthorship W4312091459A5007059750 @default.
• W4312091459 hasAuthorship W4312091459A5021237764 @default.
• W4312091459 hasAuthorship W4312091459A5060027133 @default.
• W4312091459 hasAuthorship W4312091459A5080529521 @default.
• W4312091459 hasAuthorship W4312091459A5085776207 @default.
• W4312091459 hasBestOaLocation W43120914591 @default.
• W4312091459 hasConcept C104317684 @default.
• W4312091459 hasConcept C134387633 @default.

• next