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- W4312092918 abstract "ABSTRACT Communication between the nervous and immune system is critical for development, homeostasis and response to injury. Prior to the onset of neurogenesis, microglia populate the central nervous system serving as resident immune cells over the course of life. Here, we describe new roles of an uncharacterized transcript upregulated by neurogenic progenitors during mouse corticogenesis: 4931414P19Rik (hereafter named P19). Overexpression of P19 cell-extrinsically inhibited neuronal migration and acted as chemoattractant of microglial cells. Interestingly, effects on neuronal migration were found to result as a direct consequence of P19 secretion by neural progenitors triggering microglia activation and their accumulation within the P19 targeted area. Our findings highlight the critical role of microglia activation during brain development and identify P19 as a novel player in the neuro-immune crosstalk." @default.
- W4312092918 created "2023-01-04" @default.
- W4312092918 creator A5002249161 @default.
- W4312092918 creator A5060007060 @default.
- W4312092918 date "2022-12-22" @default.
- W4312092918 modified "2023-10-10" @default.
- W4312092918 title "4931414P19Rik: A Chemoattractant Secreted by Neural Progenitors Modulates Microglia Activation and Neuronal Migration During Mammalian Brain Development" @default.
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- W4312092918 doi "https://doi.org/10.1101/2022.12.22.521648" @default.
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