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• W4312093089 abstract "<b><i>Introduction:</i></b> Little is known about the interplay between neutrophil heterogeneity in neonates in health and disease states. Olfactomedin-4 (OLFM4) marks a subset of neutrophils that have been described in adults and pediatric patients but not neonates, and this subset is thought to play a role in modulating the host inflammatory response. <b><i>Methods:</i></b> This is a prospective cohort of neonates who were born between June 2020 and December 2021 at the University of Cincinnati Medical Center NICU. Olfactomedin-4-positive (OLFM4+) neutrophils were identified in the peripheral blood using flow cytometry. <b><i>Results:</i></b> OLFM4+ neutrophil percentage was not correlated with gestational age or developmental age. Neonates with sepsis had a higher percentage than those without the condition, 66.9% (IQR 24.3–76.9%) versus 21.5% (IQR 10.6–34.7%), respectively, <i>p</i> = 0.0003. At birth, a high percentage of OLFM4+ neutrophils was associated with severe chorioamnionitis at 49.1% (IQR 28.2–61.5%) compared to those without it at 13.7% (IQR 7.7–26.3%), <i>p</i> &#x3c; 0.0001. Among neonates without sepsis, the percentages of OLFM4+ neutrophils were lower in the BPD/early death group compared to those without BPD, 11.8% (IQR 6.3–29.0%) versus 32.5% (IQR 18.5–46.1%), <i>p</i> = 0.003, and this retained significance in a multiple logistic regression model that included gestational age, birthweight, and race. <b><i>Conclusion:</i></b> This is the first study describing OLFM4+ neutrophils in neonates and it shows that this neutrophil subpopulation is not influenced by gestational age but is elevated in inflammatory conditions such as sepsis and severe chorioamnionitis, and lower percentage at birth is associated with developing bronchopulmonary dysplasia." @default.
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• W4312093089 date "2022-12-22" @default.
• W4312093089 modified "2023-09-27" @default.
• W4312093089 title "Olfactomedin-4-Positive Neutrophils in Neonates: Link to Systemic Inflammation and Bronchopulmonary Dysplasia" @default.
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• W4312093089 doi "https://doi.org/10.1159/000527902" @default.
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