FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312093090> ?p ?o ?g. }

• W4312093090 endingPage "553" @default.
• W4312093090 startingPage "543" @default.
• W4312093090 abstract "Nonalcoholic fatty liver disease is a major risk factor for hepatocellular carcinoma (HCC). Astrocyte elevated gene-1/Metadherin (AEG-1/MTDH) augments lipid accumulation (steatosis), inflammation, and tumorigenesis, thereby promoting the whole spectrum of this disease process. Targeting AEG-1 is a potential interventional strategy for nonalcoholic steatohepatitis (NASH) and HCC. Thus, proper understanding of the regulation of this molecule is essential. We found that AEG-1 is palmitoylated at residue cysteine 75 (Cys75). Mutation of Cys75 to serine (Ser) completely abolished AEG-1 palmitoylation. We identified ZDHHC6 as a palmitoyltransferase catalyzing the process in HEK293T cells. To obtain insight into how palmitoylation regulates AEG-1 function, we generated knock-in mice by CRISPR/Cas9 in which Cys75 of AEG-1 was mutated to Ser (AEG-1-C75S). No developmental or anatomical abnormality was observed between AEG-1-wild type (AEG-1-WT) and AEG-1-C75S littermates. However, global gene expression analysis by RNA-sequencing unraveled that signaling pathways and upstream regulators, which contribute to cell proliferation, motility, inflammation, angiogenesis, and lipid accumulation, were activated in AEG-1-C75S hepatocytes compared to AEG-1-WT. These findings suggest that AEG-1-C75S functions as dominant positive and that palmitoylation restricts oncogenic and NASH-promoting functions of AEG-1. We thus identify a previously unknown regulatory mechanism of AEG-1, which might help design new therapeutic strategies for NASH and HCC." @default.
• W4312093090 created "2023-01-04" @default.
• W4312093090 creator A5001339258 @default.
• W4312093090 creator A5015534740 @default.
• W4312093090 creator A5015735013 @default.
• W4312093090 creator A5032244434 @default.
• W4312093090 creator A5034492569 @default.
• W4312093090 creator A5040199794 @default.
• W4312093090 creator A5048387240 @default.
• W4312093090 creator A5056470952 @default.
• W4312093090 creator A5061441506 @default.
• W4312093090 creator A5091194969 @default.
• W4312093090 date "2022-12-22" @default.
• W4312093090 modified "2023-10-14" @default.
• W4312093090 title "Astrocyte Elevated Gene-1 Cys75 <i>S</i>-Palmitoylation by ZDHHC6 Regulates Its Biological Activity" @default.
• W4312093090 cites W1535752778 @default.
• W4312093090 cites W1859700751 @default.
• W4312093090 cites W1886282467 @default.
• W4312093090 cites W1964350129 @default.
• W4312093090 cites W1966970787 @default.
• W4312093090 cites W1975421091 @default.
• W4312093090 cites W1986827801 @default.
• W4312093090 cites W2001519284 @default.
• W4312093090 cites W2002573954 @default.
• W4312093090 cites W2011859788 @default.
• W4312093090 cites W2017611603 @default.
• W4312093090 cites W2023104359 @default.
• W4312093090 cites W2027014617 @default.
• W4312093090 cites W2032303618 @default.
• W4312093090 cites W2039678693 @default.
• W4312093090 cites W2044532338 @default.
• W4312093090 cites W2048559110 @default.
• W4312093090 cites W2057355518 @default.
• W4312093090 cites W2058148459 @default.
• W4312093090 cites W2074261333 @default.
• W4312093090 cites W2079745451 @default.
• W4312093090 cites W2096261947 @default.
• W4312093090 cites W2106330334 @default.
• W4312093090 cites W2126239901 @default.
• W4312093090 cites W2159796173 @default.
• W4312093090 cites W2164798159 @default.
• W4312093090 cites W2415876542 @default.
• W4312093090 cites W2581745547 @default.
• W4312093090 cites W2609544081 @default.
• W4312093090 cites W2782354676 @default.
• W4312093090 cites W2792710786 @default.
• W4312093090 cites W2889685677 @default.
• W4312093090 cites W2969553370 @default.
• W4312093090 cites W2969892182 @default.
• W4312093090 cites W3092250464 @default.
• W4312093090 cites W34601660 @default.
• W4312093090 cites W35736013 @default.
• W4312093090 cites W4214517857 @default.
• W4312093090 cites W4225150594 @default.
• W4312093090 doi "https://doi.org/10.1021/acs.biochem.2c00583" @default.
• W4312093090 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36548985" @default.
• W4312093090 hasPublicationYear "2022" @default.
• W4312093090 type Work @default.
• W4312093090 citedByCount "4" @default.
• W4312093090 countsByYear W43120930902023 @default.
• W4312093090 crossrefType "journal-article" @default.
• W4312093090 hasAuthorship W4312093090A5001339258 @default.
• W4312093090 hasAuthorship W4312093090A5015534740 @default.
• W4312093090 hasAuthorship W4312093090A5015735013 @default.
• W4312093090 hasAuthorship W4312093090A5032244434 @default.
• W4312093090 hasAuthorship W4312093090A5034492569 @default.
• W4312093090 hasAuthorship W4312093090A5040199794 @default.
• W4312093090 hasAuthorship W4312093090A5048387240 @default.
• W4312093090 hasAuthorship W4312093090A5056470952 @default.
• W4312093090 hasAuthorship W4312093090A5061441506 @default.
• W4312093090 hasAuthorship W4312093090A5091194969 @default.
• W4312093090 hasBestOaLocation W43120930902 @default.
• W4312093090 hasConcept C104317684 @default.
• W4312093090 hasConcept C126322002 @default.
• W4312093090 hasConcept C146727910 @default.
• W4312093090 hasConcept C173396325 @default.
• W4312093090 hasConcept C174510640 @default.
• W4312093090 hasConcept C181199279 @default.
• W4312093090 hasConcept C185592680 @default.
• W4312093090 hasConcept C2776954865 @default.
• W4312093090 hasConcept C2778772119 @default.
• W4312093090 hasConcept C2779134260 @default.
• W4312093090 hasConcept C2779201268 @default.
• W4312093090 hasConcept C502942594 @default.
• W4312093090 hasConcept C55493867 @default.
• W4312093090 hasConcept C555283112 @default.
• W4312093090 hasConcept C71924100 @default.
• W4312093090 hasConcept C86803240 @default.
• W4312093090 hasConcept C95444343 @default.
• W4312093090 hasConceptScore W4312093090C104317684 @default.
• W4312093090 hasConceptScore W4312093090C126322002 @default.
• W4312093090 hasConceptScore W4312093090C146727910 @default.
• W4312093090 hasConceptScore W4312093090C173396325 @default.
• W4312093090 hasConceptScore W4312093090C174510640 @default.
• W4312093090 hasConceptScore W4312093090C181199279 @default.
• W4312093090 hasConceptScore W4312093090C185592680 @default.
• W4312093090 hasConceptScore W4312093090C2776954865 @default.
• W4312093090 hasConceptScore W4312093090C2778772119 @default.

• next