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• W4312097261 abstract "Abstract SARS-CoV-2 Spike harbors glycans which function as ligands for lectins. Therefore, it should be possible to exploit lectins to target SARS-CoV-2 and inhibit cellular entry by binding glycans on the Spike protein. Burkholderia oklahomensis agglutinin (BOA) is an antiviral lectin that interacts with viral glycoproteins via N-linked high mannose glycans. Here, we show that BOA binds to the Spike protein and is a potent inhibitor of SARS-CoV-2 viral entry at nanomolar concentrations. Using a variety of biophysical tools, we demonstrate that the interaction is avidity driven and that BOA crosslinks the Spike protein into soluble aggregates. Furthermore, using virus neutralization assays, we demonstrate that BOA effectively inhibits all tested variants of concern as well as SARS-CoV 2003, establishing that glycan-targeting molecules have the potential to be pan-coronavirus inhibitors." @default.
• W4312097261 created "2023-01-04" @default.
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• W4312097261 date "2022-12-22" @default.
• W4312097261 modified "2023-10-11" @default.
• W4312097261 title "Targeting Spike Glycans to Inhibit SARS-CoV2 Viral Entry" @default.
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• W4312097261 doi "https://doi.org/10.1101/2022.12.22.521642" @default.
• W4312097261 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36597530" @default.
• W4312097261 hasPublicationYear "2022" @default.
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