Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312103651> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W4312103651 endingPage "734" @default.
- W4312103651 startingPage "734" @default.
- W4312103651 abstract "Abstract Cells devote extraordinary energy to translate and fold approximately 20,000 proteins encoded by the human genome. About one third of these proteins are transmembrane proteins—correctly folded in the endoplasmic reticulum (ER). The ER Unfolded Protein Response (UPRER) is a response to disturbances at the ER. As an organism ages, cells lose the ability to activate the UPRER. Our lab uses C. elegans—a microscopic roundworm—as a model organism to determine how loss of ER function can contribute to aging. The UPRER plays a key role in maintenance of functional quiescence. Quiescent cells exist in a reversible state of dormancy and can receive specific environmental cues to proliferate. The developmental state known as L1 arrest resembles the same features as quiescent cells. IRE-1 is required for worms to exit their quiescent state after starvation. Understanding the genetic pathways that are best at suppressing ire-1 terminal L1 arrest could indicate ways to improve functional quiescence. We forced the worms into an L1 arrest state; The unfolded protein response in the endoplasmic reticulum maintains functional quiescence within the cell. The worm’s ability to develop once they exit this quiescent stage effectively, indicated the ability of the worm to maintain protein homeostasis despite non-ideal conditions. It was found that all tested mutations were unable to demonstrate improvement in ability to maintain development when arrested long-term. Our data indicates that our worms were counted prematurely. In the future, we will allow for a longer growth period as well as larger quantities of food." @default.
- W4312103651 created "2023-01-04" @default.
- W4312103651 creator A5004604167 @default.
- W4312103651 date "2022-11-01" @default.
- W4312103651 modified "2023-09-28" @default.
- W4312103651 title "THE ROLE OF THE ENDOPLASMIC RETICULUM UNFOLDED PROTEIN STRESS RESPONSES IN A C. ELEGANS MODEL OF QUIESCENCE" @default.
- W4312103651 doi "https://doi.org/10.1093/geroni/igac059.2674" @default.
- W4312103651 hasPublicationYear "2022" @default.
- W4312103651 type Work @default.
- W4312103651 citedByCount "0" @default.
- W4312103651 crossrefType "journal-article" @default.
- W4312103651 hasAuthorship W4312103651A5004604167 @default.
- W4312103651 hasBestOaLocation W43121036511 @default.
- W4312103651 hasConcept C104317684 @default.
- W4312103651 hasConcept C137858568 @default.
- W4312103651 hasConcept C139447449 @default.
- W4312103651 hasConcept C158617107 @default.
- W4312103651 hasConcept C170493617 @default.
- W4312103651 hasConcept C19843653 @default.
- W4312103651 hasConcept C24530287 @default.
- W4312103651 hasConcept C2778944004 @default.
- W4312103651 hasConcept C54355233 @default.
- W4312103651 hasConcept C86803240 @default.
- W4312103651 hasConcept C95444343 @default.
- W4312103651 hasConceptScore W4312103651C104317684 @default.
- W4312103651 hasConceptScore W4312103651C137858568 @default.
- W4312103651 hasConceptScore W4312103651C139447449 @default.
- W4312103651 hasConceptScore W4312103651C158617107 @default.
- W4312103651 hasConceptScore W4312103651C170493617 @default.
- W4312103651 hasConceptScore W4312103651C19843653 @default.
- W4312103651 hasConceptScore W4312103651C24530287 @default.
- W4312103651 hasConceptScore W4312103651C2778944004 @default.
- W4312103651 hasConceptScore W4312103651C54355233 @default.
- W4312103651 hasConceptScore W4312103651C86803240 @default.
- W4312103651 hasConceptScore W4312103651C95444343 @default.
- W4312103651 hasIssue "Supplement_1" @default.
- W4312103651 hasLocation W43121036511 @default.
- W4312103651 hasLocation W43121036512 @default.
- W4312103651 hasOpenAccess W4312103651 @default.
- W4312103651 hasPrimaryLocation W43121036511 @default.
- W4312103651 hasRelatedWork W2014871980 @default.
- W4312103651 hasRelatedWork W2016300157 @default.
- W4312103651 hasRelatedWork W2030267305 @default.
- W4312103651 hasRelatedWork W2034205976 @default.
- W4312103651 hasRelatedWork W2051444335 @default.
- W4312103651 hasRelatedWork W2964211849 @default.
- W4312103651 hasRelatedWork W3049414456 @default.
- W4312103651 hasRelatedWork W3142122528 @default.
- W4312103651 hasRelatedWork W4312103651 @default.
- W4312103651 hasRelatedWork W2111797401 @default.
- W4312103651 hasVolume "6" @default.
- W4312103651 isParatext "false" @default.
- W4312103651 isRetracted "false" @default.
- W4312103651 workType "article" @default.