FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312111173> ?p ?o ?g. }

• W4312111173 endingPage "35" @default.
• W4312111173 startingPage "30" @default.
• W4312111173 abstract "Germline pathogenic variants mutations) in the BRCA1 and BRCA2 genes cause an increased risk of breast cancer and ovarian cancer. Mainstream cancer genetic testing (MCG) was introduced for breast cancer patients in our unit in 2013. Non-geneticist clinicians have been trained to offer genetic testing during initial treatment planning. We assessed the impact of timely test results on surgical decision-making.Women who had undergone mainstream genetic testing for breast cancer between September 2013 and September 2018 were identified from a prospective database. Surgical data were collected retrospectively.580 eligible women had mainstream genetic testing. For 474 this was their first breast cancer diagnosis. The median age was 46 years (interquartile range (IQR) 38-57). The indications were: age ≤45 years for 233 (49%); triple negative disease for 192 women (40.5%); bilateral breast cancer age <60 for 39 (8%) and other for 72 (14%) women. The median time for test initiation to result was 18 days (IQR 15-21). 302 (64% received results before surgery. 88% of those found to have a BRCA mutation before surgery opted for bilateral mastectomy (compared to 5% with BRCA wild type). An additional 106 patients had a new diagnosis on a background of previous treatment. Of these all with a pathogenic variant chose bilateral mastectomy.Timely BRCA gene testing influences surgeons' and patients' choice of surgery. It reassures women with a negative result and allows those with a positive result to take an active decision about the management of their future risk." @default.
• W4312111173 created "2023-01-04" @default.
• W4312111173 creator A5007424793 @default.
• W4312111173 creator A5012825265 @default.
• W4312111173 creator A5022581052 @default.
• W4312111173 creator A5028386003 @default.
• W4312111173 creator A5038029306 @default.
• W4312111173 creator A5053695213 @default.
• W4312111173 date "2023-02-01" @default.
• W4312111173 modified "2023-09-26" @default.
• W4312111173 title "Does mainstream BRCA testing affect surgical decision-making in newly-diagnosed breast cancer patients?" @default.
• W4312111173 cites W121553317 @default.
• W4312111173 cites W1984893022 @default.
• W4312111173 cites W2009199535 @default.
• W4312111173 cites W2047736807 @default.
• W4312111173 cites W2055618045 @default.
• W4312111173 cites W2062367399 @default.
• W4312111173 cites W2081943419 @default.
• W4312111173 cites W2108487228 @default.
• W4312111173 cites W2109764430 @default.
• W4312111173 cites W2111014842 @default.
• W4312111173 cites W2117576401 @default.
• W4312111173 cites W2117766313 @default.
• W4312111173 cites W2121117374 @default.
• W4312111173 cites W2124189233 @default.
• W4312111173 cites W2142230152 @default.
• W4312111173 cites W2143924924 @default.
• W4312111173 cites W2147058464 @default.
• W4312111173 cites W2158786798 @default.
• W4312111173 cites W2159026044 @default.
• W4312111173 cites W2162956417 @default.
• W4312111173 cites W2164486656 @default.
• W4312111173 cites W2297982713 @default.
• W4312111173 cites W2460201102 @default.
• W4312111173 cites W2560770257 @default.
• W4312111173 cites W2583820111 @default.
• W4312111173 cites W2627871710 @default.
• W4312111173 cites W2782723462 @default.
• W4312111173 cites W2795832917 @default.
• W4312111173 cites W2849426616 @default.
• W4312111173 cites W2883270539 @default.
• W4312111173 cites W2889478784 @default.
• W4312111173 cites W2946440976 @default.
• W4312111173 cites W2956423698 @default.
• W4312111173 cites W2961951317 @default.
• W4312111173 cites W2978115783 @default.
• W4312111173 cites W3127543690 @default.
• W4312111173 cites W3145040052 @default.
• W4312111173 cites W4235071680 @default.
• W4312111173 cites W4248030523 @default.
• W4312111173 doi "https://doi.org/10.1016/j.breast.2022.12.001" @default.
• W4312111173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36577271" @default.
• W4312111173 hasPublicationYear "2023" @default.
• W4312111173 type Work @default.
• W4312111173 citedByCount "3" @default.
• W4312111173 countsByYear W43121111732023 @default.
• W4312111173 crossrefType "journal-article" @default.
• W4312111173 hasAuthorship W4312111173A5007424793 @default.
• W4312111173 hasAuthorship W4312111173A5012825265 @default.
• W4312111173 hasAuthorship W4312111173A5022581052 @default.
• W4312111173 hasAuthorship W4312111173A5028386003 @default.
• W4312111173 hasAuthorship W4312111173A5038029306 @default.
• W4312111173 hasAuthorship W4312111173A5053695213 @default.
• W4312111173 hasBestOaLocation W43121111731 @default.
• W4312111173 hasConcept C119060515 @default.
• W4312111173 hasConcept C121608353 @default.
• W4312111173 hasConcept C126322002 @default.
• W4312111173 hasConcept C131872663 @default.
• W4312111173 hasConcept C143998085 @default.
• W4312111173 hasConcept C2776738285 @default.
• W4312111173 hasConcept C2777757722 @default.
• W4312111173 hasConcept C2780194787 @default.
• W4312111173 hasConcept C2780427987 @default.
• W4312111173 hasConcept C2780673598 @default.
• W4312111173 hasConcept C2910039337 @default.
• W4312111173 hasConcept C2910584544 @default.
• W4312111173 hasConcept C29456083 @default.
• W4312111173 hasConcept C530470458 @default.
• W4312111173 hasConcept C54355233 @default.
• W4312111173 hasConcept C71924100 @default.
• W4312111173 hasConcept C86803240 @default.
• W4312111173 hasConceptScore W4312111173C119060515 @default.
• W4312111173 hasConceptScore W4312111173C121608353 @default.
• W4312111173 hasConceptScore W4312111173C126322002 @default.
• W4312111173 hasConceptScore W4312111173C131872663 @default.
• W4312111173 hasConceptScore W4312111173C143998085 @default.
• W4312111173 hasConceptScore W4312111173C2776738285 @default.
• W4312111173 hasConceptScore W4312111173C2777757722 @default.
• W4312111173 hasConceptScore W4312111173C2780194787 @default.
• W4312111173 hasConceptScore W4312111173C2780427987 @default.
• W4312111173 hasConceptScore W4312111173C2780673598 @default.
• W4312111173 hasConceptScore W4312111173C2910039337 @default.
• W4312111173 hasConceptScore W4312111173C2910584544 @default.
• W4312111173 hasConceptScore W4312111173C29456083 @default.
• W4312111173 hasConceptScore W4312111173C530470458 @default.
• W4312111173 hasConceptScore W4312111173C54355233 @default.
• W4312111173 hasConceptScore W4312111173C71924100 @default.
• W4312111173 hasConceptScore W4312111173C86803240 @default.

• next