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- W4312113310 abstract "Class A, rhodopsin-like, G-protein-coupled receptors (GPCRs) are by far the largest class of GPCRs and are integral membrane proteins used by various cells to convert extracellular signals into intracellular responses. Initially, class A GPCRs were believed to function as monomers, but a growing body of evidence has emerged to suggest that these receptors can function as homodimers and heterodimers and can undergo functional crosstalk to influence the actions of agonists or antagonists acting at each receptor. This review will focus on the angiotensin type 1 (AT1 ) and type 2 (AT2 ) receptors, as well as the relaxin family peptide receptor 1 (RXFP1), each of which have their unique characteristics but have been demonstrated to undergo some level of interaction when appropriately co-expressed, which influences the function of each receptor. In particular, this receptor functional crosstalk will be discussed in the context of fibrosis, the tissue scarring that results from a failed wound-healing response to injury, and which is a hallmark of chronic disease and related organ dysfunction." @default.
- W4312113310 created "2023-01-04" @default.
- W4312113310 creator A5002416368 @default.
- W4312113310 creator A5029379615 @default.
- W4312113310 creator A5070440854 @default.
- W4312113310 creator A5071949320 @default.
- W4312113310 date "2023-01-17" @default.
- W4312113310 modified "2023-09-25" @default.
- W4312113310 title "Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis" @default.
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