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- W4312113359 abstract "Abstract Because of pleiotropy, mutations affect the expression and inheritance of multiple traits and, together with selection, are expected to shape standing genetic covariances between traits and eventual phenotypic divergence between populations. It is therefore important to find if the M matrix, describing mutational variances of each trait and covariances between traits, varies between genotypes. We here estimate the M matrix for six locomotion behavior traits in lines of two genotypes of the nematode Caenorhabditis elegans that accumulated mutations in a nearly neutral manner for 250 generations. We find significant mutational variance along at least one phenotypic dimension of the M matrices, but neither their size nor their orientation had detectable differences between genotypes. The number of generations of mutation accumulation, or the number of MA lines measured, was likely insufficient to sample enough mutations and detect potentially small differences between the two M matrices. We then tested if the M matrices were similar to one G matrix describing the standing genetic (co)variances of a population derived by the hybridization of several genotypes, including the two measured for M, and domesticated to a lab-defined environment for 140 generations. We found that the M and G were different because the genetic covariances caused by mutational pleiotropy in the two genotypes are smaller than those caused by linkage disequilibrium in the lab population. We further show that M matrices differed in their alignment with the lab population G matrix. If generalized to other founder genotypes of the lab population, these observations indicate that selection does not shape the evolution of the M matrix for locomotion behavior in the short-term of a few tens to hundreds of generations and suggests that the hybridization of C. elegans genotypes allows selection on new phenotypic dimensions of locomotion behavior." @default.
- W4312113359 created "2023-01-04" @default.
- W4312113359 creator A5003657160 @default.
- W4312113359 creator A5044560298 @default.
- W4312113359 creator A5067872894 @default.
- W4312113359 creator A5088400383 @default.
- W4312113359 date "2022-12-22" @default.
- W4312113359 modified "2023-10-18" @default.
- W4312113359 title "Variation in mutational (co)variances" @default.
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- W4312113359 doi "https://doi.org/10.1093/g3journal/jkac335" @default.
- W4312113359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36548954" @default.
- W4312113359 hasPublicationYear "2022" @default.
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