Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312113452> ?p ?o ?g. }
- W4312113452 abstract "Single-cell protein therapeutics is expected to promote our in-depth understanding of how a specific protein with a therapeutic dosage treats the cell without population averaging. However, it has not yet been tackled by current single-cell nanotools. We address this challenge by the use of a double-barrel nanopipette, in which one lumen was used for electroosmotic cytosolic protein delivery and the other was customized for ionic evaluation of the consequence. Upon injection of protein DJ-1 through the delivery lumen, upregulation of the antioxidant protein could protect neural PC-12 cells against oxidative stress from phorbol myristate acetate exposure, as deduced by targeting of the cytosolic hydrogen peroxide by the detecting lumen. The nanotool developed in this study for single-cell protein therapeutics provides a perspective for future single-cell therapeutics involving different therapeutic modalities, such as peptides, enzymes and nucleic acids." @default.
- W4312113452 created "2023-01-04" @default.
- W4312113452 creator A5010404267 @default.
- W4312113452 creator A5027824355 @default.
- W4312113452 creator A5040040696 @default.
- W4312113452 creator A5042717531 @default.
- W4312113452 creator A5050812850 @default.
- W4312113452 creator A5062506108 @default.
- W4312113452 creator A5078530516 @default.
- W4312113452 creator A5085249984 @default.
- W4312113452 creator A5090629412 @default.
- W4312113452 date "2023-01-24" @default.
- W4312113452 modified "2023-10-15" @default.
- W4312113452 title "Electrochemical Single‐Cell Protein Therapeutics Using a Double‐Barrel Nanopipette" @default.
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