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• W4312113519 endingPage "480" @default.
• W4312113519 startingPage "471" @default.
• W4312113519 abstract "Rationally designing microstructures of soft hydrogels for specific biological functionalization is a challenge in tissue engineering applications. A novel and affordable soft hydrogel scaffold is constructed here by incorporating polyphenol modules with lysozyme amyloid fibrils (Lys AFs) via non-covalent self-assembly. Embedded polyphenols not only trigger hydrogel formation but also determine gel behavior by regulating the polyphenol gallol density and complex ratio. The feasibility of using a polyphenol–Lys AF hydrogel as a biocompatible cell scaffold, which is conducive to cell proliferation and spreading, is also shown. Notably, introducing polyphenols imparts the corresponding hydrogels a superior cell bioadhesive efficiency without further biofunctional decoration and thus may be successfully employed in both healthy and cancer cell lines. Confocal laser scanning microscopy also reveals that the highly expressed integrin-mediated focal adhesions form due to stimulation of the polyphenol–AF composite hydrogel, direct cell adhesion, proliferation, and spreading. Overall, this work constitutes a significant step forward in creating highly adhesive tissue culture platforms for in vitro culture of different cell types and may greatly expand prospects for future biomaterial design and development." @default.
• W4312113519 created "2023-01-04" @default.
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• W4312113519 date "2022-12-22" @default.
• W4312113519 modified "2023-09-30" @default.
• W4312113519 title "Highly Adhesive Amyloid–Polyphenol Hydrogels for Cell Scaffolding" @default.
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• W4312113519 doi "https://doi.org/10.1021/acs.biomac.2c01311" @default.
• W4312113519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36548941" @default.
• W4312113519 hasPublicationYear "2022" @default.
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