Matches in SemOpenAlex for { <https://semopenalex.org/work/W4312113746> ?p ?o ?g. }
- W4312113746 abstract "Abstract Chromatin structural organization, gene expression and proteostasis are intricately regulated in a wide range of biological processes, both physiological and pathological. Protein acetylation, a major post-translational modification, is tightly involved in interconnected biological networks, modulating the activation of gene transcription and protein action in cells. A very large number of studies describe the pivotal role of the so-called acetylome (accounting for more than 80% of the human proteome) in orchestrating different pathways in response to stimuli and triggering severe diseases, including cancer. NAA60/NatF (N-terminal acetyltransferase F), also named HAT4 (histone acetyltransferase type B protein 4), is a newly discovered acetyltransferase in humans modifying N-termini of transmembrane proteins starting with M–K/M-A/M-V/M-M residues and is also thought to modify lysine residues of histone H4. Because of its enzymatic features and unusual cell localization on the Golgi membrane, NAA60 is an intriguing acetyltransferase that warrants biochemical and clinical investigation. Although it is still poorly studied, this review summarizes current findings concerning the structural hallmarks and biological role of this novel targetable epigenetic enzyme." @default.
- W4312113746 created "2023-01-04" @default.
- W4312113746 creator A5028482826 @default.
- W4312113746 creator A5042642459 @default.
- W4312113746 creator A5042993199 @default.
- W4312113746 creator A5086152631 @default.
- W4312113746 creator A5090354837 @default.
- W4312113746 date "2022-12-01" @default.
- W4312113746 modified "2023-10-14" @default.
- W4312113746 title "NAA60 (HAT4): the newly discovered bi-functional Golgi member of the acetyltransferase family" @default.
- W4312113746 cites W1531477522 @default.
- W4312113746 cites W1586131224 @default.
- W4312113746 cites W174118980 @default.
- W4312113746 cites W1882070008 @default.
- W4312113746 cites W1883668892 @default.
- W4312113746 cites W191946090 @default.
- W4312113746 cites W196082105 @default.
- W4312113746 cites W1967363545 @default.
- W4312113746 cites W1968058162 @default.
- W4312113746 cites W1975014056 @default.
- W4312113746 cites W1975692560 @default.
- W4312113746 cites W1985991629 @default.
- W4312113746 cites W1986206360 @default.
- W4312113746 cites W1986815188 @default.
- W4312113746 cites W1991660464 @default.
- W4312113746 cites W1992902970 @default.
- W4312113746 cites W2006897037 @default.
- W4312113746 cites W2007884336 @default.
- W4312113746 cites W2012593128 @default.
- W4312113746 cites W2012895942 @default.
- W4312113746 cites W2015158204 @default.
- W4312113746 cites W2019948656 @default.
- W4312113746 cites W2031173027 @default.
- W4312113746 cites W2032041863 @default.
- W4312113746 cites W2032961316 @default.
- W4312113746 cites W2038429428 @default.
- W4312113746 cites W2042429611 @default.
- W4312113746 cites W2045131701 @default.
- W4312113746 cites W2052932569 @default.
- W4312113746 cites W2055397908 @default.
- W4312113746 cites W2061683926 @default.
- W4312113746 cites W2063028204 @default.
- W4312113746 cites W2064846679 @default.
- W4312113746 cites W2065886910 @default.
- W4312113746 cites W2070526549 @default.
- W4312113746 cites W2071955851 @default.
- W4312113746 cites W2072517432 @default.
- W4312113746 cites W2073889204 @default.
- W4312113746 cites W2082944633 @default.
- W4312113746 cites W2083195949 @default.
- W4312113746 cites W2084784918 @default.
- W4312113746 cites W2088060011 @default.
- W4312113746 cites W2089130436 @default.
- W4312113746 cites W2091956705 @default.
- W4312113746 cites W2092735199 @default.
- W4312113746 cites W2092918092 @default.
- W4312113746 cites W2109027544 @default.
- W4312113746 cites W2111199460 @default.
- W4312113746 cites W2111578933 @default.
- W4312113746 cites W2114506570 @default.
- W4312113746 cites W2114874351 @default.
- W4312113746 cites W2115930136 @default.
- W4312113746 cites W2118520292 @default.
- W4312113746 cites W2120722343 @default.
- W4312113746 cites W2130879922 @default.
- W4312113746 cites W2141929116 @default.
- W4312113746 cites W2150101433 @default.
- W4312113746 cites W2156222068 @default.
- W4312113746 cites W2159385826 @default.
- W4312113746 cites W2172867362 @default.
- W4312113746 cites W2201987966 @default.
- W4312113746 cites W2259202917 @default.
- W4312113746 cites W2274048361 @default.
- W4312113746 cites W2284990905 @default.
- W4312113746 cites W2287107628 @default.
- W4312113746 cites W2291365506 @default.
- W4312113746 cites W2338607927 @default.
- W4312113746 cites W2402892277 @default.
- W4312113746 cites W2405840972 @default.
- W4312113746 cites W2412721048 @default.
- W4312113746 cites W2425379846 @default.
- W4312113746 cites W2431163235 @default.
- W4312113746 cites W2474059146 @default.
- W4312113746 cites W2498723612 @default.
- W4312113746 cites W2511106300 @default.
- W4312113746 cites W2546624599 @default.
- W4312113746 cites W2588714631 @default.
- W4312113746 cites W2607257714 @default.
- W4312113746 cites W2620564586 @default.
- W4312113746 cites W2734420271 @default.
- W4312113746 cites W2762045905 @default.
- W4312113746 cites W2789605661 @default.
- W4312113746 cites W2791526053 @default.
- W4312113746 cites W2794404825 @default.
- W4312113746 cites W2883210621 @default.
- W4312113746 cites W2883357866 @default.
- W4312113746 cites W2883652577 @default.
- W4312113746 cites W2890142544 @default.
- W4312113746 cites W2901932654 @default.
- W4312113746 cites W2902113375 @default.